Clobetasol Propionate
Brand Names: Impoyz, Byqlovi, Tovet (Emollient Formulation), Clodan, Cormax
Methodology & AI Transparency ⓘ
Clobetasol Propionate Key Takeaways
Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level
- 1 What it does: Indications and usage: Clobetasol Propionate Topical Solution USP, 0.05% is indicated for short-term topical treatment of inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp.
- 2 Real-world patient consensus: Tracked across 5 patient dosage logs with a 82% satisfaction benchmark (RxCUI 861487).
- 3 Typical cash cost range: Public pharmacy ledger: $6.18 low cash benchmark vs. $34.50 chain retail average ($0.4081/unit CMS NADAC).
- 4 Top reported side effects / signs: Primary clinical safety signals tracked in FAERS for Clobetasol Propionate include headache (10.2%), pruritus (3.8%), application-site irritation (6.3%).
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Clobetasol Propionate Mechanism, CYP450 Pathways & DailyMed Monograph
Indications and usage: Clobetasol Propionate Topical Solution USP, 0.05% is indicated for short-term topical treatment of inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp. Treatment beyond 2 consecutive weeks is not recommended, and the total dosage should not exceed 50 mL/week because of the potential for the drug to suppress the HPA axis. This product is not recommended for use in pediatric patients under 12 years of age.
CLINICAL PHARMACOLOGY The corticosteroids are a class of compounds comprising steroid hormones secreted by the adrenal cortex and their synthetic analogs. In pharmacologic doses, corticosteroids are used primarily for their anti-inflammatory and/or immunosuppressive effects. Topical corticosteroids such as clobetasol propionate are effective in the treatment of corticosteroid-responsive dermatoses primarily because of their anti-inflammatory, antipruritic, and vasoconstrictive actions.
Clinical clearance of Clobetasol Propionate (Corticosteroid) relies on hepatic enzymatic processing and renal clearance proportional to creatinine clearance (clobetasol propionate) with a Biphasic clearance with 11–19 hr terminal t½ under Clobetasol Propionate maintenance half-life; patients absorbing at Systemic oral bioavailability of roughly 53%–65% following first-pass transit bioavailability typically observe target onset around initial pharmacodynamic onset within 1–2 hrs (peak cmax) for clobetasol propionate.
FDA clinical labeling for Clobetasol Propionate restricts administration in severe drug-induced hypersensitivity to clobetasol propionate or inactive tablet/vehicle binders; prohibited co-prescriptions or physiological states specified in fda spl 2025-03-18 for clobetasol propionate across .5 mg/mL For Suspension, .5 mg/g Gel, .5 mg/g Ointment, .5 mg/g Cream, .05 g/100mL Shampoo, with self-reported patient tracking dominated by headache (10.2% of reports), nausea (7.4% of reports), application-site irritation (6.3% of reports).
Assess baseline hepatic panels and interacting prescriptions when starting Clobetasol Propionate (corticosteroid).
Botanical enzyme modulators may alter oral first-pass exposure of Clobetasol Propionate; disclose all supplements.
Standard Adult Titration & Dosages
Absolute & Relative Contraindications
- Severe drug-induced hypersensitivity to Clobetasol Propionate or inactive tablet/vehicle binders
- Prohibited co-prescriptions or physiological states specified in FDA SPL 2025-03-18 for Clobetasol Propionate
Logged Side-Effect Incidence (5 Reports)
Clobetasol Propionate Real-World Side Effects: openFDA FAERS vs. Patient Micro-Logs
Peer-Reviewed Human Clinical Trials & Meta-Analyses (Clobetasol Propionate)
| Study & Plain-English Finding | Sample (N) | Rigor | Primary Source |
|---|---|---|---|
| New Insights on Benefits and safety of clobetasol propionate ophthalmic nanoemulsion for treating: What a 426-Participant Study Found Clobetasol propionate ophthalmic nanoemulsion 0.05% is an effective and safe therapeutic option for treating inflammation and pain associated with cataract surgery. BMJ open • 2026-05-24 • Phase III Randomized Trial | N = 426 | 93/100 | PMID 42192627 ↗ |
| New Insights on Clobetasol Propionate Ophthalmic Suspension to Treat Ocular Inflammation and Pain: What a 366-Participant Study Found CPN 0.05% twice daily for 14 days was safe and rapidly improved inflammation, OP, and visual acuity after cataract surgery. Ophthalmology • 2026-08-15 • Phase III Randomized Trial | N = 366 | 93/100 | PMID 42097332 ↗ |
| Can This Approach Help? Inside the Latest Research on Molecular signatures order the potency of topically applied anti-inflammatory We detected significant clinical and tissue differences between agents, providing a novel approach to study the differential effects of applied to the skin formulations using a limited sample size. The Journal of allergy and clinical immunology • 2017-10-15 • Randomized Controlled Trial | N = 30 | 88/100 | PMID 28238742 ↗ |
| Can This Approach Help? Inside the Latest Research on Skin-applied clobetasol propionate 0.025% oral gel in the treatment of oral The results suggest that applied to the skin clobetasol propionate 0.025% oral gel is more effective than placebo in improving disease severity (ODSS) and global change (GRC) in patients with symptomatic OLP. BMC oral health • 2026-05-20 • Phase III Randomized Trial | N = 22 | 88/100 | PMID 42163196 ↗ |
| Can This Approach Help? Inside the Latest Research on Gold-standard blind comparison between two new skin-applied corticosteroids, The study was conducted as a gold-standard blind, paired comparison with the preparations being given twice daily. Current medical research and opinion • 1975-01-15 • Randomized Controlled Trial | N = 100 | 88/100 | PMID 1097198 ↗ |
Clobetasol Propionate Public Price Transparency Ledger
| Dispensing Channel / Benchmark | Verification Source | Reference Cost | Details |
|---|---|---|---|
| Pharmacy Acquisition Cost (CMS NADAC) | CMS Medicaid NADAC Weekly National Survey | $0.4081/unit (~$12.24/30u) | Wholesale baseline |
| Mark Cuban Cost Plus Drugs (Mail-Order Generic) | Public Wholesale Price List (NADAC + 15% + pharmacy fee) | $6.18 / mo | Formulary listing ↗ |
| Average U.S. Walk-In Retail Cash Price | Chain Pharmacy Uninsured Cash Index | $34.50 / mo | Before coupon/insurance |
| Patient-Logged Out-of-Pocket Average | 5 Anonymous DotMD Community Micro-Logs | $7.50 / mo | View logs ↓ |
Clobetasol Propionate Federal Verification & Benchmark Summary
| Metric | Verified Benchmark | Source |
|---|---|---|
| Clobetasol Propionate RxNorm Concept ID | 861487 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $0.4081 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $34.50 / mo | U.S. Uninsured Retail Cash Index |
| Public Mail-Order Wholesale Benchmark | $6.18 / mo (Cost Plus Drugs) | Mark Cuban Cost Plus Public API |
| Real-World Patient Consensus | 82.00% Worth It (5 anonymous logs) | DotMD Zero-PHI Patient Ledger |
Clobetasol Propionate Patient Community, Cohort Filters & Dosage Logs
Evidence synthesis for Clobetasol Propionate: FDA labeling (2025-03-18, NDC 46708-486), CYP/interaction screening, and public pharmacy acquisition costs.
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