Clonidine
Brand Names: Nexiclon XR, Catapres
Methodology & AI Transparency ⓘ
Clonidine Key Takeaways
Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level
- 1 What it does: Indications and usage: Clonidine transdermal system is indicated in the treatment of hypertension.
- 2 Real-world patient consensus: 75% patient "Worth It" rating across 12 anonymous logs for Clonidine (RxNorm 998671).
- 3 Typical cash cost range: Dispensing cost comparison spans $5.60 mail/discount cash up to $34.50 uninsured retail (federal NADAC $6.5450).
- 4 Top reported side effects / signs: Leading openFDA/SPL adverse events for Clonidine: nausea (11.8%), headache (10.4%), dizziness (6.1%).
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Clonidine Mechanism, CYP450 Pathways & DailyMed Monograph
Indications and usage: Clonidine transdermal system is indicated in the treatment of hypertension. It may be employed alone or concomitantly with other antihypertensive agents.
CLINICAL PHARMACOLOGY Clonidine stimulates alpha-adrenoreceptors in the brain stem. This action results in reduced sympathetic outflow from the central nervous system and in decreases in peripheral resistance, renal vascular resistance, heart rate, and blood pressure. Renal blood flow and glomerular filtration rate remain essentially unchanged. Normal postural reflexes are intact; therefore, orthostatic symptoms are mild and infrequent.
Pharmacokinetic profiling of Clonidine demonstrates an elimination half-life of Terminal t½ estimated at 4–9 hrs depending on renal/hepatic reserve (Clonidine) with F ≈ 46%–58% systemic availability after standard oral Clonidine administration systemic bioavailability; clearance proceeds via mixed metabolic conjugation and unchanged urinary excretion across clonidine regimens, reaching clinical onset within time to peak concentration spans 1 to 2 hrs under clonidine maintenance.
Titration schedules for Clonidine (.2 mg/24h Patch, Extended Release → .3 mg/d Patch → .17 mg/1 Tablet, Extended Release → .1 mg/d Patch → 100 ug/mL Injection, Solution) require excluding contraindications clonidine transdermal system should not be used in patients with known hypersensitivity to clonidine or to any other component of the system.; prior anaphylaxis, angioedema, or severe hypersensitivity to clonidine or clonidine excipients; real-world patient logs highlight nausea (11.8% of reports), headache (10.4% of reports), somnolence (6.8% of reports) alongside a 75.00% Worth-It consensus.
Avoid overlapping central alpha-2 adrenergic agonist prescriptions alongside Clonidine to prevent cumulative receptor toxicity.
Shifts in intragastric pH can modestly influence dissolution kinetics of oral Clonidine dosage forms.
Standard Adult Titration & Dosages
Absolute & Relative Contraindications
- CONTRAINDICATIONS Clonidine transdermal system should not be used in patients with known hypersensitivity to clonidine or to any other component of the system.
- Prior anaphylaxis, angioedema, or severe hypersensitivity to Clonidine or Clonidine excipients
Logged Side-Effect Incidence (12 Reports)
Clonidine Real-World Side Effects: openFDA FAERS vs. Patient Micro-Logs
Peer-Reviewed Human Clinical Trials & Meta-Analyses (Clonidine)
| Study & Plain-English Finding | Sample (N) | Rigor | Primary Source |
|---|---|---|---|
| New Insights on A single intra-articular injection of JTA-004, a combination of human plasma,: What a 746-Participant Study Found A single IA injection of JTA-004 was not superior to a saline solution (LSmean difference: -1.50 mm, 95%CI 5.12; 2.12, p= 0.42) or Synvisc-One® (LSmean difference: 2.40, 95% CI: -1.22; 6.02, p=0.20) for the treatment of OA... Osteoarthritis and cartilage • 2026-02-15 • Phase III Randomized Trial | N = 746 | 93/100 | PMID 41015076 ↗ |
| Can This Approach Help? Inside the Latest Research on Efficacy of clonidine and melatonin for treating trouble sleeping in anxious Notably, the incidence of adverse effects did not differ significantly among the three groups. BMC pediatrics • 2026-03-05 • Randomized Controlled Trial | Multi-cohort | 88/100 | PMID 41781909 ↗ |
| Can This Approach Help? Inside the Latest Research on Benefits and safety OF LIDOCAINE WITH CLONIDINE FOR MAXILLARY INFILTRATION Shorter onset and prolonged duration of maxillary infiltration anesthesia are present in DMT2 setting. The journal of evidence-based dental practice • 2025-06-15 • Phase III Randomized Trial | Multi-cohort | 88/100 | PMID 40335197 ↗ |
| Can This Approach Help? Inside the Latest Research on Benefits and safety of Extended-Release Clonidine Hydrochloride for Attention CLON-XR was efficacious and well tolerated in Chinese children and adolescents with ADHD, supporting its potential as a nonstimulant treatment option in this population. Journal of child and adolescent psychopharmacology • 2026-06-15 • Phase III Randomized Trial | N = 75 | 88/100 | PMID 41944053 ↗ |
| Managing ADHD: Can Use of sleep medication Make a Real Difference? (What New Research Reveals) Sleep medication use is common in children with ADHD and is associated with combined-type ADHD and use of ADHD medication. Sleep medicine • 2014-04-15 • Randomized Controlled Trial | Multi-cohort | 82/100 | PMID 24684977 ↗ |
Clonidine Public Price Transparency Ledger
| Dispensing Channel / Benchmark | Verification Source | Reference Cost | Details |
|---|---|---|---|
| Pharmacy Acquisition Cost (CMS NADAC) | CMS Medicaid NADAC Weekly National Survey | $6.5450/unit (~$196.35/30u) | Wholesale baseline |
| Mark Cuban Cost Plus Drugs (Mail-Order Generic) | Public Wholesale Price List (NADAC + 15% + pharmacy fee) | $5.60 / mo | Formulary listing ↗ |
| Average U.S. Walk-In Retail Cash Price | Chain Pharmacy Uninsured Cash Index | $34.50 / mo | Before coupon/insurance |
| Patient-Logged Out-of-Pocket Average | 12 Anonymous DotMD Community Micro-Logs | $7.50 / mo | View logs ↓ |
| Sesame Direct Cash-Pay Prescriber Network (Licensed Telehealth Cash Program) | State-licensed clinician review • ~1d mail fulfillment | $29.00 consult | Program details |
Clonidine Federal Verification & Benchmark Summary
| Metric | Verified Benchmark | Source |
|---|---|---|
| Clonidine RxNorm Concept ID | 998671 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $6.5450 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $34.50 / mo | U.S. Uninsured Retail Cash Index |
| Public Mail-Order Wholesale Benchmark | $5.60 / mo (Cost Plus Drugs) | Mark Cuban Cost Plus Public API |
| Real-World Patient Consensus | 75.00% Worth It (12 anonymous logs) | DotMD Zero-PHI Patient Ledger |
Clonidine Patient Community, Cohort Filters & Dosage Logs
Cross-verified Clonidine (central alpha-2 adrenergic agonist) monograph synthesizing RxNorm 998671, openFDA FAERS signals, and $5.60–$34.50 cash benchmarks.
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