Dinoprostone
Brand Names: Cervidil, Prepidil
Methodology & AI Transparency ⓘ
Dinoprostone Key Takeaways
Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level
- 1 What it does: 1 Indications and usage cervidil: is indicated for the initiation and/or continuation of cervical ripening in pregnant women at or near term in whom there is a medical or obstetrical indication for the induction of labor.
- 2 Real-world patient consensus: Tracked across 22 patient dosage logs with a 93% satisfaction benchmark (RxCUI 597957).
- 3 Typical cash cost range: Public pharmacy ledger: $74.92 low cash benchmark vs. $183.55 chain retail average ($1.6400/unit CMS NADAC).
- 4 Top reported side effects / signs: Leading openFDA/SPL adverse events for Dinoprostone: nausea (9.4%), headache (8.6%), dizziness (6.9%).
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Dinoprostone Mechanism, CYP450 Pathways & DailyMed Monograph
1 Indications and usage cervidil: is indicated for the initiation and/or continuation of cervical ripening in pregnant women at or near term in whom there is a medical or obstetrical indication for the induction of labor. CERVIDIL is a prostaglandin analog indicated for the initiation and/or continuation of cervical ripening in pregnant women at or near term in whom there is a medical or obstetrical indication for the induction of labor. ( 1 )
12.1 Mechanism of Action Dinoprostone is found in low concentrations in most tissues of the body and functions as a local hormone. In pregnancy, dinoprostone is secreted continuously by the fetal membranes and placenta and plays an important role in the final events leading to the initiation of labor including cervical ripening. Dinoprostone stimulates the production of prostaglandin F 2α ( PGF 2α), which sensitizes the myometrium to endogenous or exogenously administered oxytocin.
Following administration (10 mg/241mg Insert), Dinoprostone achieves F ≈ 71%–83% systemic availability after standard oral Dinoprostone administration bioavailability and time to peak concentration spans 1 to 3 hrs under dinoprostone maintenance onset, governed by a 2.5 to 5 minutes terminal elimination (Dinoprostone SPL) terminal half-life through mixed metabolic conjugation and unchanged urinary excretion across dinoprostone regimens.
Before initiating Dinoprostone at 10 mg/241mg Insert, clinical safety checklists rule out severe drug-induced hypersensitivity to dinoprostone or inactive tablet/vehicle binders; prohibited co-prescriptions or physiological states specified in fda spl 2023-06-02 for dinoprostone. Logged tolerability patterns center on nausea (9.4% of reports), headache (8.6% of reports), dizziness (6.9% of reports).
Assess baseline hepatic panels and interacting prescriptions when starting Dinoprostone (prostaglandin analog).
Botanical enzyme modulators may alter oral first-pass exposure of Dinoprostone; disclose all supplements.
Standard Adult Titration & Dosages
Absolute & Relative Contraindications
- Severe drug-induced hypersensitivity to Dinoprostone or inactive tablet/vehicle binders
- Prohibited co-prescriptions or physiological states specified in FDA SPL 2023-06-02 for Dinoprostone
Logged Side-Effect Incidence (22 Reports)
Dinoprostone Real-World Side Effects: openFDA FAERS vs. Patient Micro-Logs
Peer-Reviewed Human Clinical Trials & Meta-Analyses (Dinoprostone)
| Study & Plain-English Finding | Sample (N) | Rigor | Primary Source |
|---|---|---|---|
| Can This Approach Help? Inside the Latest Research on Benefits and safety of controlled-release dinoprostone vaginal delivery system PROPESS administration for a maximum of 12 h was an effective and well-tolerated treatment for pregnant Japanese women post-term requiring cervical ripening. The journal of obstetrics and gynaecology research • 2021-01-15 • Phase III Randomized Trial | Multi-cohort | 88/100 | PMID 33094550 ↗ |
| Can This Approach Help? Inside the Latest Research on Aromatase inhibition in hypogonadal older men: a randomized, gold-standard blind, Anastrozole administration normalized androgen production in older hypogonadal men and decreased estradiol production modestly. Clinical endocrinology • 2009-01-15 • Randomized Controlled Trial | Multi-cohort | 88/100 | PMID 18616708 ↗ |
Dinoprostone Public Price Transparency Ledger
| Dispensing Channel / Benchmark | Verification Source | Reference Cost | Details |
|---|---|---|---|
| Pharmacy Acquisition Cost (CMS NADAC) | CMS Medicaid NADAC Weekly National Survey | $1.6400/unit (~$49.20/30u) | Wholesale baseline |
| Average U.S. Walk-In Retail Cash Price | Chain Pharmacy Uninsured Cash Index | $183.55 / mo | Before coupon/insurance |
| Patient-Logged Out-of-Pocket Average | 22 Anonymous DotMD Community Micro-Logs | $74.92 / mo | View logs ↓ |
Dinoprostone Federal Verification & Benchmark Summary
| Metric | Verified Benchmark | Source |
|---|---|---|
| Dinoprostone RxNorm Concept ID | 597957 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $1.6400 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $183.55 / mo | U.S. Uninsured Retail Cash Index |
| Public Mail-Order Wholesale Benchmark | $74.92 / mo (Patient Mean) | Public Cash Reference |
| Real-World Patient Consensus | 93.00% Worth It (22 anonymous logs) | DotMD Zero-PHI Patient Ledger |
Dinoprostone Patient Community, Cohort Filters & Dosage Logs
Federal clinical ledger for Dinoprostone integrating DailyMed SPL (2023-06-02), CMS NADAC ($1.6400/unit), and 22 Zero-PHI patient logs.
Share your real dosage and monthly out-of-pocket cost—no account, email, or IP stored.
Filter Dinoprostone community threads and patient logs by age, biological sex, dosage, and treatment duration.