Sodium Sulfacetamide

INDICATIONS Sodium Sulfacetamide is intended for topical application in the following scaling dermatoses: Seborrheic dermatitis and seborrhea sicca (dandruff). It also is indicated for the treatment of secondary bacterial infections of the skin due to organisms susceptible to sulfonamides.

CLINICAL PHARMACOLOGY Sodium sulfacetamide exerts a bacteriostatic effect against sulfonamide sensitive gram positive and gram-negative microorganisms commonly isolated from secondary cutaneous pyogenic infections. It acts by restricting the synthesis of folic acid required by bacteria for growth, by its competition with para-aminobenzoic acid. There is no clinical data available on the degree and rate of systemic absorption of this product when applied to the skin or scalp. However, significant absorption of sodium sulfacetamide through the skin has been reported.

Systemic exposure to Sodium Sulfacetamide reflects F ≈ 64%–76% systemic availability after standard oral Sodium Sulfacetamide administration absorption kinetics and mixed metabolic conjugation and unchanged urinary excretion across sodium sulfacetamide regimens, sustaining receptor engagement across a Terminal t½ estimated at 4–17 hrs depending on renal/hepatic reserve (Sodium Sulfacetamide) half-life window (time to peak concentration spans 1 to 2 hrs under sodium sulfacetamide maintenance response profile).

Dosing protocols (100 mg/mL Liquid or 100 mg/mL Shampoo or 100 mg/g Liquid or 100 mg/mL Lotion or 10% Bottle of Solution) balance efficacy (93.00% patient satisfaction across 11 logs) against diarrhea (7.9% of reports), nausea (7% of reports), application-site irritation (6.5% of reports), with strict avoidance in contraindications this product is contraindicated in persons with known or suspected hypersensitivity to any of the ingredients of the product.; this product is not to be used by patients with kidney disease..