Ziprasidone Hydrochloride (Ziprasidone HCl)
Brand Names: Ziprasidone Hydrochloride
Methodology & AI Transparency ⓘ
Ziprasidone Hydrochloride (Ziprasidone HCl) Key Takeaways
Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level
- 1 What it does: Within the Atypical Antipsychotic category, Ziprasidone Hydrochloride provides branded delivery of active moiety Ziprasidone HCl (cross-referenced at /meds/ziprasidone-mesylate) (registered by Apotex Corp.; NDC 60505-2528, 60505-2529).
- 2 Real-world patient consensus: Registered under RxNorm 313776 and SPL 2026-07-20, pairing Ziprasidone Hydrochloride packaging with active ingredient Ziprasidone HCl.
- 3 Typical cash cost range: Public pharmacy ledger: $24.20 low cash benchmark vs. $64.13 chain retail average ($0.2181/unit CMS NADAC).
- 4 Top reported side effects / signs: Most commonly reported Ziprasidone Hydrochloride (Ziprasidone HCl) tolerability events: cutaneous rash (5.5%), orthostatic hypotension (2.1%), application-site erythema (7.8%).
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Ziprasidone Hydrochloride (Ziprasidone HCl) Mechanism, CYP450 Pathways & DailyMed Monograph
Within the Atypical Antipsychotic category, Ziprasidone Hydrochloride provides branded delivery of active moiety Ziprasidone HCl (cross-referenced at /meds/ziprasidone-mesylate) (registered by Apotex Corp.; NDC 60505-2528, 60505-2529). Characterized by 40 mg/1 Capsule; 80 mg/1 Capsule under 2026-07-20 SPL documentation, Ziprasidone Hydrochloride targets Ziprasidone capsules are indicated for the treatment of schizophrenia, as monotherapy for the acute treatment of bipolar.
Through its Ziprasidone HCl active moiety, Ziprasidone Hydrochloride exerts atypical antipsychotic activity with class-characteristic hepatorenal disposition. Registered under NDC 60505-2528, 60505-2529 (registered by Apotex Corp.; effective 2026-07-20), the 40 mg/1 Capsule; 80 mg/1 Capsule presentation ensures reproducible pharmacokinetic release profiles documented in federal RxNorm (313776) and CMS NADAC ($0.2181/unit) ledgers.
With Trace plasma half-life; Ziprasidone Hydrochloride (Ziprasidone HCl) acts primarily within superficial target tissue residence kinetics and < 5% transdermal or mucosal systemic uptake from Ziprasidone Hydrochloride (Ziprasidone HCl) bioavailability, Ziprasidone Hydrochloride (Ziprasidone HCl) undergoes local esterase/enzymatic cleavage of ziprasidone hydrochloride (ziprasidone hcl) with minimal hepatic cytochrome burden and establishes therapeutic activity over initial local symptom modulation in 30–90 minutes; full tissue response over 1–3 weeks (ziprasidone hydrochloride (ziprasidone hcl)).
Standard adult regimens span 40 mg/1 Capsule, 80 mg/1 Capsule, 60 mg/1 Capsule, 20 mg/1 Capsule, 20mg Capsule. Prescribers screen specifically against severe drug-induced hypersensitivity to ziprasidone hcl or inactive tablet/vehicle binders; prohibited co-prescriptions or physiological states specified in fda spl 2026-07-20 for ziprasidone hydrochloride (ziprasidone hcl), while community micro-logs most frequently note application-site erythema (7.8% of reports), mild local dryness (6.4% of reports), cutaneous rash (5.5% of reports).
Assess baseline hepatic panels and interacting prescriptions when starting Ziprasidone Hydrochloride (Ziprasidone HCl) (atypical antipsychotic).
Botanical enzyme modulators may alter oral first-pass exposure of Ziprasidone Hydrochloride (Ziprasidone HCl); disclose all supplements.
Standard Adult Titration & Dosages
Absolute & Relative Contraindications
- Severe drug-induced hypersensitivity to Ziprasidone HCl or inactive tablet/vehicle binders
- Prohibited co-prescriptions or physiological states specified in FDA SPL 2026-07-20 for Ziprasidone Hydrochloride (Ziprasidone HCl)
Logged Side-Effect Incidence (16 Reports)
Ziprasidone Hydrochloride (Ziprasidone HCl) Real-World Side Effects: openFDA FAERS vs. Patient Micro-Logs
Peer-Reviewed Human Clinical Trials & Meta-Analyses (Ziprasidone Hydrochloride (Ziprasidone HCl))
| Study & Plain-English Finding | Sample (N) | Rigor | Primary Source |
|---|---|---|---|
| Can This Approach Help? Inside the Latest Research on Efficacy and tolerability of adjunctive ziprasidone in treatment-resistant In this preliminary study of antidepressant-resistant subjects with major depression, adjunctive ziprasidone was associated with greater clinical effect than was continued sertraline single-drug treatment and was generally... The Journal of clinical psychiatry • 2007-07-15 • Randomized Controlled Trial | N = 21 | 82/100 | PMID 17685744 ↗ |
Ziprasidone Hydrochloride (Ziprasidone HCl) Public Price Transparency Ledger
| Dispensing Channel / Benchmark | Verification Source | Reference Cost | Details |
|---|---|---|---|
| Pharmacy Acquisition Cost (CMS NADAC) | CMS Medicaid NADAC Weekly National Survey | $0.2181/unit (~$6.54/30u) | Wholesale baseline |
| Average U.S. Walk-In Retail Cash Price | Chain Pharmacy Uninsured Cash Index | $64.13 / mo | Before coupon/insurance |
| Patient-Logged Out-of-Pocket Average | 16 Anonymous DotMD Community Micro-Logs | $24.20 / mo | View logs ↓ |
Ziprasidone Hydrochloride (Ziprasidone HCl) Federal Verification & Benchmark Summary
| Metric | Verified Benchmark | Source |
|---|---|---|
| Ziprasidone Hydrochloride (Ziprasidone HCl) RxNorm Concept ID | 313776 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $0.2181 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $64.13 / mo | U.S. Uninsured Retail Cash Index |
| Public Mail-Order Wholesale Benchmark | $24.20 / mo (Patient Mean) | Public Cash Reference |
| Real-World Patient Consensus | 75.00% Worth It (16 anonymous logs) | DotMD Zero-PHI Patient Ledger |
Ziprasidone Hydrochloride (Ziprasidone HCl) Patient Community, Cohort Filters & Dosage Logs
Federal clinical ledger for Ziprasidone Hydrochloride (Ziprasidone HCl) integrating DailyMed SPL (2026-07-20), CMS NADAC ($0.2181/unit), and 16 Zero-PHI patient logs.
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Filter Ziprasidone Hydrochloride (Ziprasidone HCl) community threads and patient logs by age, biological sex, dosage, and treatment duration.