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Depression, Bipolar & Mood Disorders • ICD-10-CM F29

Psychosis - atypical

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM F29 • 8 Linked .gov / PubMed Citations • Governance: Dr. Hannah Lindqvist, MD, PhD (NPI #1457952647)
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Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Psychosis - atypical Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

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What Is Psychosis - atypical?

Within Depression, Bipolar & Mood Disorders practice, Psychosis - atypical (ICD-10 F29) is stratified through medication response pharmacogenomics [Psychosis - atypical F29], pairing targeted symptom control with longitudinal Serum Vitamin D in Psychosis - atypical (F29: & RBC Folate) surveillance.

Pathophysiology, Underlying Causes & Clinical Presentation

Underlying Psychosis - atypical (code F29) is monoaminergic (serotonin [Psychosis - atypical F29], which Depression, Bipolar & Mood Disorders clinicians address while surveilling TSH & Free in Psychosis - atypical (F29: T4 Rule-Out) (TSH 0.8 – 2.5 mIU/L (F29)).

Common Symptoms & Clinical Signs

  • • Presentation of Psychosis - atypical (F29): loss of interest in Psychosis - atypical (F29: or pleasure in)
  • • Secondary Psychosis - atypical clinical sign: persistent low mood, in Psychosis - atypical (F29: emotional flatness, or)
  • • Symptom flares in Psychosis - atypical correlating with TSH & Free in Psychosis - atypical (F29: T4 Rule-Out) deviation outside TSH 0.8 – 2.5 mIU/L (F29)
  • • Functional depression & mood impact requiring medication response pharmacogenomics [Psychosis - atypical F29] evaluation (F29)

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Psychosis - atypical Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code F29 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Depression, Bipolar & Mood Disorders NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: TSH & Free in Psychosis - atypical (F29: T4 Rule-Out) TSH 0.8 – 2.5 mIU/L (F29) Clinical Reference Target Range
Diagnostic / Lab Marker: Serum Vitamin D in Psychosis - atypical (F29: & RBC Folate) 25(OH)D 40 – 65 ng/mL (F29) Clinical Reference Target Range
Diagnostic / Lab Marker: PHQ-9 Symptom Severity in Psychosis - atypical (F29: Score) < 4 (clinical remission) (F29) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Psychosis - atypical

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Medication Pharmacologic Class Patient Worth-It CMS NADAC / Unit Typical Lowest Cash
Quetiapine Fumarate Seroquel • RxCUI 312743 Atypical Antipsychotic 92% $0.0209 $ 5.35 /mo
Clozaril (Clozapine) Clozaril • RxCUI 104775 Atypical Antipsychotic 94% $6.2959 $ 461.80 /mo
Asenapine Secuado, Saphris • RxCUI 859975 Atypical Antipsychotic 94% $2.3627 $ 57.01 /mo
Cariprazine Vraylar • RxCUI RXN-61874130-2392 Atypical Antipsychotic 88% $48.5295 $ 185.00 /mo
Vraylar (Cariprazine) Vraylar • RxCUI RXN-B61874130 Atypical Antipsychotic 94% $48.5295 $ 640.00 /mo
Lybalvi (Olanzapine and Samidorphan L-Malate) Lybalvi • RxCUI 2570398 Atypical Antipsychotic 81% $52.5028 $ 640.00 /mo
Risperidone Risperdal Consta, Risperdal • RxCUI 312830 Atypical Antipsychotic 87% $0.0358 $ 5.36 /mo
Latuda (Lurasidone Hydrochloride) Latuda • RxCUI 1040036 Atypical Antipsychotic 80% $45.3287 $ 7.45 /mo
Olanzapine and Fluoxetine (Olanzapine and Fuoxetine) Olanzapine and Fluoxetine • RxCUI 403970 Atypical Antipsychotic 85% $4.0280 $ 298.52 /mo
Saphris (Asenapine Maleate) Saphris • RxCUI 1606337-B04562410 Atypical Antipsychotic 93% $20.1874 $ 57.01 /mo
Olanzapine Pamoate Zyprexa Relprevv, Zyprexa • RxCUI 1718925 FDA Prescription Therapeutic Agent 79% $0.1069 $ 12.83 /mo
Risperdal (Risperidone) Risperdal • RxCUI 312828-B50458330 Atypical Antipsychotic 82% $9.1619 $ 5.36 /mo
Seroquel XR (Quetiapine) Seroquel XR • RxCUI 721791 Atypical Antipsychotic 93% $14.1432 $ 7.14 /mo
Ziprasidone Hydrochloride (Ziprasidone HCl) Ziprasidone Hydrochloride • RxCUI 313776 Atypical Antipsychotic 75% $0.2181 $ 24.20 /mo
Rexulti (Brexpiprazole) Rexulti • RxCUI RXN-B59148036 Atypical Antipsychotic 89% $48.3704 $ 640.00 /mo
Paliperidone Invega • RxCUI 672567 Atypical Antipsychotic 93% $1.0186 $ 49.75 /mo
Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Psychosis - atypical)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Normalization of EEG in depression after antidepressant treatment with: What a 1,008-Participant Study Found

Response rates in patients with normalized EEG taking sertraline were significantly larger than in subjects treated with escitalopram/venlafaxine.

Journal of affective disorders • 2019-12-01 • Randomized Controlled Trial
N = 1,008 90/100 PMID 31437703 ↗
Can This Approach Help? Inside the Latest Research on Real-world benefits and safety of adding celecoxib to escitalopram for improving

Adding celecoxib to escitalopram may improve symptoms of depression in patients with depression without increasing the risk of drug-related side effects.

International journal of psychiatry in medicine • 2024-09-15 • Randomized Controlled Trial
N = 60 88/100 PMID 38116669 ↗
Can This Approach Help? Inside the Latest Research on Safety and real-world benefits of pimavanserin in patients with Lewy body

Psychosis relapse risk was significantly lower with pimavanserin vs.

BMC neurology • 2025-11-24 • Phase III Randomized Trial
N = 22 88/100 PMID 41286676 ↗
Can This Approach Help? Inside the Latest Research on Trial of sertraline versus venlafaxine XR in major depression: efficacy and

Sertraline and venlafaxine XR demonstrated comparable effects on QOL and efficacy in treatment of major depression, although sertraline may be associated with a lower symptom burden during treatment discontinuation and a...

The Journal of clinical psychiatry • 2005-10-15 • Randomized Controlled Trial
N = 163 88/100 PMID 16259546 ↗
Can This Approach Help? Inside the Latest Research on Efficacy of Transdermal Estradiol and Micronized Progesterone in the Prevention

Twelve months of TE+IMP were more effective than placebo in preventing the development of clinically significant depressive symptoms among initially euthymic perimenopausal and early postmenopausal women.

JAMA psychiatry • 2018-02-01 • Randomized Controlled Trial
Multi-cohort 88/100 PMID 29322164 ↗
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