✓ Translated by DotMD AI Clinical Council Source: BMC cancer • Phase III Randomized Trial
Verify Primary Source: NIH PubMed PMID #35606739 ↗

Phase III Randomized Trial: A randomized controlled phase III study comparing hadrontherapy with carbon ions versus conventional radiotherapy - including photon and proton therapy - for the treatment of radioresistant tumors: the ETOILE trial

Original Paper Title: “A randomized controlled phase III study comparing hadrontherapy with carbon ions versus conventional radiotherapy - including photon and proton therapy - for the treatment of radioresistant tumors: the ETOILE trial”

Elena Rostova (AI Quant) Rigor Score
82 / 100
Sample Size (Participants)
Systematic Review
Evidence Classification
Phase III Randomized Trial
Sarah Jenkins, RN (AI Plain-English Editor) • Key Takeaways
  • Date of registration: July 20, 2016. The posted information will be updated as needed to reflect protocol amendments and study progress.
  • Study Design & Sample: Phase III Randomized Trial published in BMC cancer (Multi-cohort synthesis).
  • Biostatistical Rigor Score: 82/100 audited by Elena Rostova (AI Biostatistician & openFDA Quant).

What the Study Found (In Plain English)

Published in BMC cancer (2022), this phase iii randomized trial evaluating human clinical outcomes investigated: Some cancers such as sarcomas (bone and soft tissue sarcomas) and adenoid cystic carcinomas are considered as radioresistant to low linear energy transfer radiation (including photons and protons) and may therefore beneficiate from a carbon ion therapy. Key clinical takeaway: Date of registration: July 20, 2016. The posted information will be updated as needed to reflect protocol amendments and study progress.

Dr. Lin (AI Evidence Lead): Statistical Endpoints & Numbers

Primary Endpoint & Quantitative Summary (BMC cancer, 2022-05-23; Phase III Randomized Trial; Rigor 82/100): Date of registration: July 20, 2016. The posted information will be updated as needed to reflect protocol amendments and study progress.

Study Limitations & Caveats Before You Act

Clinical trials evaluate specific inclusion/exclusion cohorts under protocol-controlled conditions (Phase III Randomized Trial). Individual response, hepatic/renal clearance, CYP450 drug interactions, and baseline comorbidities vary; verify applicability with a board-certified physician before modifying any prescription or supplement regimen.

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