✓ Translated by DotMD AI Clinical Council Source: Journal of hypertension • Randomized Controlled Trial
Verify Primary Source: NIH PubMed PMID #21063203 ↗

Randomized Controlled Trial: Calcium channel blocker and Rho-associated kinase activity in patients with hypertension (N = 14)

Original Paper Title: “Calcium channel blocker and Rho-associated kinase activity in patients with hypertension”

Elena Rostova (AI Quant) Rigor Score
82 / 100
Sample Size (Participants)
N = 14
Evidence Classification
Randomized Controlled Trial
Sarah Jenkins, RN (AI Plain-English Editor) • Key Takeaways
  • These findings suggest that calcium channel blocker amlodipine inhibits ROCK activity in patients with hypertension.
  • Study Design & Sample: Randomized Controlled Trial published in Journal of hypertension (N = 14 human participants).
  • Biostatistical Rigor Score: 82/100 audited by Elena Rostova (AI Biostatistician & openFDA Quant).

What the Study Found (In Plain English)

Published in Journal of hypertension (2011), this randomized controlled trial evaluating 14 human participants investigated: Rho-associated kinases (ROCKs) play an important role in Ca sensitization and vascular resistance. Key clinical takeaway: These findings suggest that calcium channel blocker amlodipine inhibits ROCK activity in patients with hypertension.

Dr. Lin (AI Evidence Lead): Statistical Endpoints & Numbers

Primary Endpoint & Quantitative Summary (Journal of hypertension, 2011-02-15; N = 14; Rigor 82/100): These findings suggest that calcium channel blocker amlodipine inhibits ROCK activity in patients with hypertension.

Study Limitations & Caveats Before You Act

Clinical trials evaluate specific inclusion/exclusion cohorts under protocol-controlled conditions (Randomized Controlled Trial). Individual response, hepatic/renal clearance, CYP450 drug interactions, and baseline comorbidities vary; verify applicability with a board-certified physician before modifying any prescription or supplement regimen.

Related DotMD Clinical Hubs & Price Ledgers

Rx: amlodipine-besylate → Rx: amlodipine → Rx: angiotensin-ii → Rx: losartan-potassium → Condition: renovascular-hypertension → Condition: jugular-vein-thrombosis →
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