✓ Translated by DotMD AI Clinical Council Source: Journal of endocrinological investigation • Randomized Controlled Trial
Verify Primary Source: NIH PubMed PMID #7000879 ↗

Randomized Controlled Trial: Double-blind group comparative study of testosterone undecanoate and mesterolone in hypogonadal male patients

Original Paper Title: “Double-blind group comparative study of testosterone undecanoate and mesterolone in hypogonadal male patients”

Elena Rostova (AI Quant) Rigor Score
88 / 100
Sample Size (Participants)
Systematic Review
Evidence Classification
Randomized Controlled Trial
Sarah Jenkins, RN (AI Plain-English Editor) • Key Takeaways
  • TU induced a marked improvement of the sexual activity and of the mental state. After 4 weeks of treatment the effects were significantly better than in the M-treated group: libido (p less than 0.001), erections (p less than 0.01), ejaculations (p less than 0.05) and mental state (p less than 0.001).
  • Study Design & Sample: Randomized Controlled Trial published in Journal of endocrinological investigation (Multi-cohort synthesis).
  • Biostatistical Rigor Score: 88/100 audited by Elena Rostova (AI Biostatistician & openFDA Quant).

What the Study Found (In Plain English)

Published in Journal of endocrinological investigation (1980), this randomized controlled trial evaluating human clinical outcomes investigated: A double-blind, randomized, group comparative study was performed in hypogonadal male patients in order to compare the effects on sexual activity and mental state of testosterone undecanoate (TU) and mesterolone (M). Key clinical takeaway: TU induced a marked improvement of the sexual activity and of the mental state. After 4 weeks of treatment the effects were significantly better than in the M-treated group: libido (p less than 0.001), erections (p less than 0.01), ejaculations (p less than 0.05) and mental state (p less...

Dr. Lin (AI Evidence Lead): Statistical Endpoints & Numbers

Primary Endpoint & Quantitative Summary (Journal of endocrinological investigation, 1980-01-15; Randomized Controlled Trial; Rigor 88/100): TU induced a marked improvement of the sexual activity and of the mental state. After 4 weeks of treatment the effects were significantly better than in the M-treated group: libido (p less than 0.001), erections (p less than 0.01), ejaculations (p less than 0.05) and mental state (p less than 0.001).

Study Limitations & Caveats Before You Act

Clinical trials evaluate specific inclusion/exclusion cohorts under protocol-controlled conditions (Randomized Controlled Trial). Individual response, hepatic/renal clearance, CYP450 drug interactions, and baseline comorbidities vary; verify applicability with a board-certified physician before modifying any prescription or supplement regimen.

Related DotMD Clinical Hubs & Price Ledgers

Rx: testosterone-cypionate → Rx: testosterone → Condition: clinical-trials → Condition: testicular-dysfunction → Condition: corporo-venous-occlusive-erectile-dysfunction →
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