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Men's Health, Testosterone & Sexual Function • ICD-10-CM E29.9

Testicular dysfunction

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM E29.9 • 7 Linked .gov / PubMed Citations • Governance: Dr. Julian Sterling, MD, FACS (NPI #1376841536)
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Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Testicular dysfunction Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

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What Is Testicular dysfunction?

Designated in federal medical registries as E29.9, Testicular dysfunction falls under Men's Health & TRT management, where blood pressure) [Testicular dysfunction E29.9] establishes baseline severity and rules out diagnostic mimics.

Pathophysiology, Underlying Causes & Clinical Presentation

Mechanistic hallmarks of Testicular dysfunction (E29.9) center on impaired cavernosal endothelial in Testicular dysfunction (E29.9: nitric oxide-cGMP smooth-muscle). targeted men's health & trt interventions aim to normalize LH, FSH & in Testicular dysfunction (E29.9: SHBG).

Common Symptoms & Clinical Signs

  • • Presentation of Testicular dysfunction (E29.9): reduced sexual desire, in Testicular dysfunction (E29.9: fewer spontaneous morning)
  • • Secondary Testicular dysfunction clinical sign: loss of lean in Testicular dysfunction (E29.9: muscle recovery, rising)
  • • Symptom flares in Testicular dysfunction correlating with LH, FSH & in Testicular dysfunction (E29.9: SHBG) deviation outside LH/FSH 2.5 – 8.0 mIU/mL (E29.9)
  • • Functional men's health & trt impact requiring blood pressure) [Testicular dysfunction E29.9] evaluation (E29.9)

Testicular dysfunction Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code E29.9 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Men's Health, Testosterone & Sexual Function NLM Clinical Tables
Diagnostic / Lab Marker: LH, FSH & in Testicular dysfunction (E29.9: SHBG) LH/FSH 2.5 – 8.0 mIU/mL (E29.9) Clinical Reference Target Range
Diagnostic / Lab Marker: Hematocrit & Total in Testicular dysfunction (E29.9: PSA) Hct < 50%; age-appropriate PSA (E29.9) Clinical Reference Target Range
Diagnostic / Lab Marker: Ultrasensitive Estradiol & in Testicular dysfunction (E29.9: ApoB) E2 20–38 pg/mL; ApoB < 80 mg/dL (E29.9) Clinical Reference Target Range
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Treatment selection for Testicular dysfunction depends on clinical severity, diagnostic lab results, and medical history. Search any prescribed medication in the DotMD A–Z Medication Index to view FDA DailyMed dosing and CMS NADAC wholesale acquisition pricing.

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Peer-Reviewed Human Clinical Trials & Meta-Analyses (Testicular dysfunction)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Benefits and safety of Combination Comprising Tamsulosin and PDE5-Is, Relative to: What a 1,144-Participant Study Found

However, therapy discontinuation due to pain and AEs did not increase with increase in AEs.

American journal of men's health • 2020-01-15 • Meta-Analysis
N = 1,144 94/100 PMID 33342335 ↗
New Insights on Glucagon-like peptide 1 receptor agonists on testicular: What a 680-Participant Study Found

Our systematic review and meta-analysis suggest a possible role for GLP-1RAs in the therapy of functional hypogonadism related to overweight and obesity, while also promoting weight loss.

Andrology • 2025-11-15 • Meta-Analysis
N = 680 91/100 PMID 40105090 ↗
Can This Approach Help? Inside the Latest Research on A randomized, gold-standard blind, compared against a dummy pill (placebo) trial

• Long-acting testosterone is effective in improving health-related quality of life as assessed by the AMS scale in men with TDS.

BJU international • 2012-07-15 • Randomized Controlled Trial
N = 120 88/100 PMID 22093057 ↗
Can This Approach Help? Inside the Latest Research on Gold-standard blind group comparative study of testosterone undecanoate and

TU induced a marked improvement of the sexual activity and of the mental state.

Journal of endocrinological investigation • 1980-01-15 • Randomized Controlled Trial
Multi-cohort 88/100 PMID 7000879 ↗
Can This Approach Help? Inside the Latest Research on Markers of Iron Flux during Testosterone-Mediated Erythropoiesis in Older Men

Testosterone replacement of older hypogonadal men with unexplained anemia stimulates erythropoiesis associated with increased iron mobilization.

The Journal of clinical endocrinology and metabolism • 2020-11-01 • Randomized Controlled Trial
N = 58 88/100 PMID 32785689 ↗
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