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✓ Translated by DotMD AI Clinical Council Source: Journal of cardiovascular pharmacology and therapeutics • Randomized Controlled Trial
Verify Primary Source: NIH PubMed PMID #21386036 ↗

Randomized Controlled Trial: Effect of atorvastatin monotherapy and low-dose atorvastatin/ezetimibe combination on fasting and postprandial triglycerides in combined hyperlipedemia (N = 78)

Original Paper Title: “Effect of atorvastatin monotherapy and low-dose atorvastatin/ezetimibe combination on fasting and postprandial triglycerides in combined hyperlipedemia”

Elena Rostova (AI Quant) Rigor Score
82 / 100
Sample Size (Participants)
N = 78
Evidence Classification
Randomized Controlled Trial
Sarah Jenkins, RN (AI Plain-English Editor) • Key Takeaways
  • The reduction in apo B/A1 was greater in the combination group (-32% ± 19% and -42% ± 13%, in the atorvastatin and combination groups, respectively, P = .02).
  • Study Design & Sample: Randomized Controlled Trial published in Journal of cardiovascular pharmacology and therapeutics (N = 78 human participants).
  • Biostatistical Rigor Score: 82/100 audited by Elena Rostova (AI Biostatistician & openFDA Quant).

What the Study Found (In Plain English)

Published in Journal of cardiovascular pharmacology and therapeutics (2012), this randomized controlled trial evaluating 78 human participants investigated: Postprandial triglyceride (TG) levels are easy to measure and are associated with future cardiovascular risk. Key clinical takeaway: The reduction in apo B/A1 was greater in the combination group (-32% ± 19% and -42% ± 13%, in the atorvastatin and combination groups, respectively, P = .02).

Dr. Lin (AI Evidence Lead): Statistical Endpoints & Numbers

Primary Endpoint & Quantitative Summary (Journal of cardiovascular pharmacology and therapeutics, 2012-03-15; N = 78; Rigor 82/100): The reduction in apo B/A1 was greater in the combination group (-32% ± 19% and -42% ± 13%, in the atorvastatin and combination groups, respectively, P = .02).

Study Limitations & Caveats Before You Act

Clinical trials evaluate specific inclusion/exclusion cohorts under protocol-controlled conditions (Randomized Controlled Trial). Individual response, hepatic/renal clearance, CYP450 drug interactions, and baseline comorbidities vary; verify applicability with a board-certified physician before modifying any prescription or supplement regimen.

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