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Cholesterol, Triglycerides & Lipids • ICD-10-CM E78.1

Triglycerides

Also known as: Hypertriglyceridemia

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM E78.1 • 8 Linked .gov / PubMed Citations • Governance: Dr. Marcus Thorne, MD, FACC (NPI #1184629314)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Triglycerides Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

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What Is Triglycerides?

What are triglycerides? Triglycerides are a type of fat. They are the most common type of fat in your body. They come from foods, especially butter, oils, and other fats you eat. Triglycerides also come from extra calories. These are the calories that you eat, but your body does not need right away. Your body changes these extra calories into triglycerides and stores them in fat cells. When your body needs energy, it releases the triglycerides. Your VLDL cholesterol particles carry the triglycerides to your tissues. Having a high level of triglycerides can raise your risk of heart diseases , such as coronary artery disease .

Pathophysiology, Underlying Causes & Clinical Presentation

Underlying Triglycerides (code E78.1) is remnant cholesterol accumulation [Triglycerides E78.1], Cross-referenced with NIH MeSH (Hypertriglyceridemia), which Cholesterol, Triglycerides & Lipids clinicians address while surveilling Lipoprotein(a) [Lp(a)] [Triglycerides E78.1] (< 75 nmol/L (E78.1)).

Common Symptoms & Clinical Signs

  • • Regularly eating more calories than you burn off, especially if you eat a lot of sugar
  • • Being overweight or having obesity
  • • Presentation of Triglycerides (E78.1): achilles tendon thickening, in Triglycerides (E78.1: xanthelasma, or premature)
  • • Secondary Triglycerides clinical sign: coronary artery calcium [Triglycerides E78.1]

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Triglycerides Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code E78.1 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Cholesterol, Triglycerides & Lipids NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: Lipoprotein(a) [Lp(a)] [Triglycerides E78.1] < 75 nmol/L (E78.1) Clinical Reference Target Range
Diagnostic / Lab Marker: Apolipoprotein B (ApoB) [Triglycerides E78.1] < 70 mg/dL (< 55 mg/dL high risk) (E78.1) Clinical Reference Target Range
Diagnostic / Lab Marker: LDL Cholesterol [Triglycerides E78.1] < 85 mg/dL (E78.1) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Triglycerides

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Treatment selection for Triglycerides depends on clinical severity, diagnostic lab results, and medical history. Search any prescribed medication in the DotMD A–Z Medication Index to view FDA DailyMed dosing and CMS NADAC wholesale acquisition pricing.

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Peer-Reviewed Human Clinical Trials & Meta-Analyses (Triglycerides)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Benefits and safety of the PCSK9 Inhibitor Evolocumab in Patients with Mixed high: What a 1,148-Participant Study Found

The significant reductions of atherogenic lipids including LDL-C, non-HDL-C, and apolipoprotein B seen with evolocumab are similar in patients with and without mixed high cholesterol.

Cardiovascular drugs and therapy • 2016-06-15 • Phase III Randomized Trial
N = 1,148 96/100 PMID 27240673 ↗
New Insights on Lipid-altering efficacy of the ezetimibe/simvastatin single tablet versus: What a 2,959-Participant Study Found

Ezetimibe/simvastatin was more effective than rosuvastatin in LDL-C lowering, and provided greater or comparable improvements in other lipid measures and hsCRP at the approved usual starting, next highest, and maximum doses in...

Current medical research and opinion • 2006-10-15 • Randomized Controlled Trial
N = 2,959 96/100 PMID 17022864 ↗
New Insights on Effect of evolocumab or ezetimibe added to moderate- or high-intensity statin: What a 2,067-Participant Study Found

Evolocumab reduced LDL-C levels by 66% (95% CI, 58% to 73%) to 75% (95% CI, 65% to 84%) (every 2 weeks) and by 63% (95% CI, 54% to 71%) to 75% (95% CI, 67% to 83%) (monthly) vs placebo at the mean of weeks 10 and 12 in the...

JAMA • 2014-05-14 • Phase III Randomized Trial
N = 2,067 96/100 PMID 24825642 ↗
New Insights on Benefits and safety of ezetimibe coadministered with lovastatin in primary high: What a 548-Participant Study Found

Ezetimibe plus lovastatin was well tolerated, with a safety profile similar to both lovastatin alone and placebo.

The American journal of cardiology • 2003-02-15 • Randomized Controlled Trial
N = 548 93/100 PMID 12586255 ↗
New Insights on Tirzepatide, a Dual GIP and GLP-1 RA, on Lipid and Metabolite Profiles in: What a 259-Participant Study Found

Tirzepatide reduces body weight and improves blood sugar control and uniquely modulates metabolites associated with T2D risk and metabolic dysregulation in a direction consistent with improved metabolic health.

The Journal of clinical endocrinology and metabolism • 2022-01-18 • Randomized Controlled Trial
N = 259 93/100 PMID 34608929 ↗
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