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Cholesterol, Triglycerides & Lipids • ICD-10-CM E78.8

HDL: The "Good" Cholesterol

Also known as: High-density lipoprotein

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM E78.8 • 8 Linked .gov / PubMed Citations • Governance: Dr. Marcus Thorne, MD, FACC (NPI #1184629314)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

HDL: The "Good" Cholesterol Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

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What Is HDL: The "Good" Cholesterol?

What is cholesterol? Cholesterol is a waxy, fat-like substance that's found in all the cells in your body. Your liver makes cholesterol, and it is also in some foods, such as meat and dairy products. Your body needs some cholesterol to work properly. But having too much cholesterol in your blood raises your risk of coronary artery disease . What are HDL and LDL? HDL and LDL are two types of lipoproteins.They are a combination of fat (lipid) and protein. The lipids need to be attached to the proteins so they can move through the blood. HDL and LDL have different purposes: HDL stands for high-density lipoproteins.

Pathophysiology, Underlying Causes & Clinical Presentation

HDL: The "Good" Cholesterol (E78.8) alters cholesterol & lipids homeostasis through excess VLDL particle in HDL: The "Good" Cholesterol (E78.8: assembly); Cross-referenced with NIH MeSH (Cholesterol, HDL), clinical remission targets LDL Cholesterol [HDL: The "Good" Cholesterol E78.8] within < 85 mg/dL (E78.8).

Common Symptoms & Clinical Signs

  • • The first test should be between ages 9 to 11
  • • Children should have the test again every 5 years
  • • Presentation of HDL: The "Good" Cholesterol (E78.8): elevated triglyceride-to-HDL ratio [HDL: The "Good" Cholesterol E78.8]
  • • Secondary HDL: The "Good" Cholesterol clinical sign: premature family history in HDL: The "Good" Cholesterol (E78.8: of coronary stenting,)

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

HDL: The "Good" Cholesterol Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code E78.8 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Cholesterol, Triglycerides & Lipids NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: Apolipoprotein B (ApoB) [HDL: The "Good" Cholesterol E78.8] < 70 mg/dL (< 55 mg/dL high risk) (E78.8) Clinical Reference Target Range
Diagnostic / Lab Marker: LDL Cholesterol [HDL: The "Good" Cholesterol E78.8] < 85 mg/dL (E78.8) Clinical Reference Target Range
Diagnostic / Lab Marker: Fasting Triglycerides [HDL: The "Good" Cholesterol E78.8] < 100 mg/dL (E78.8) Clinical Reference Target Range
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FDA-Monographed Medications & Public Cash Price Reference for HDL: The "Good" Cholesterol

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Peer-Reviewed Human Clinical Trials & Meta-Analyses (HDL: The "Good" Cholesterol)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Real-world benefits and safety of rosuvastatin versus atorvastatin, simvastatin,: What a 2,431-Participant Study Found

Adult Treatment Panel III LDL cholesterol goals were achieved by 82% to 89% of patients treated with rosuvastatin 10 to 40 mg compared with 69% to 85% of patients treated with atorvastatin 10 to 80 mg; the European LDL...

The American journal of cardiology • 2003-07-15 • Randomized Controlled Trial
N = 2,431 90/100 PMID 12860216 ↗
Can This Approach Help? Inside the Latest Research on Association of Plasma Ceramides and Sphingomyelin With VLDL apoB-100 Fractional

Plasma ceramides and sphingomyelin were not associated with the kinetics or concentrations of high-density lipoprotein apoA-I, and low-density lipoprotein apoB.

The Journal of clinical endocrinology and metabolism • 2015-06-15 • Randomized Controlled Trial
N = 12 88/100 PMID 25816050 ↗
Can This Approach Help? Inside the Latest Research on Efficacy and Tolerability of Ezetimibe/Atorvastatin Fixed-dose Combination Versus

Of the 454 patients enrolled, 412 (90.7%) completed the study.

Clinical therapeutics • 2022-10-15 • Phase III Randomized Trial
N = 88 88/100 PMID 36182594 ↗
Can This Approach Help? Inside the Latest Research on Influence of pravastatin and atorvastatin on markers of oxidative stress in

This study suggests that statin therapy results in variable effects on oxidative stress markers in hypercholesterolemic subjects.

Journal of the American College of Cardiology • 2008-04-29 • Randomized Controlled Trial
N = 120 88/100 PMID 18436117 ↗
Can This Approach Help? Inside the Latest Research on Ceramides and phospholipids are downregulated with liraglutide treatment: results

Compared with placebo, liraglutide treatment led to a significant downregulation in ceramides, phospholipids and triglycerides, which all are linked to higher risk of CVD.

BMJ open diabetes research & care • 2021-09-15 • Randomized Controlled Trial
N = 102 88/100 PMID 34518158 ↗
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