✓ Translated by DotMD AI Clinical Council Source: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas • Randomized Controlled Trial
Verify Primary Source: NIH PubMed PMID #19030713 ↗

Randomized Controlled Trial: Effect of melatonin administration on subjective sleep quality in chronic obstructive pulmonary disease (N = 12)

Original Paper Title: “Effect of melatonin administration on subjective sleep quality in chronic obstructive pulmonary disease”

Elena Rostova (AI Quant) Rigor Score
88 / 100
Sample Size (Participants)
N = 12
Evidence Classification
Randomized Controlled Trial
Sarah Jenkins, RN (AI Plain-English Editor) • Key Takeaways
  • We conclude that melatonin can improve sleep in COPD. Further long-term studies involving larger number of patients are needed before melatonin can be safely recommended for the management of sleep disturbances in these patients.
  • Study Design & Sample: Randomized Controlled Trial published in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas (N = 12 human participants).
  • Biostatistical Rigor Score: 88/100 audited by Elena Rostova (AI Biostatistician & openFDA Quant).

What the Study Found (In Plain English)

Published in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas (2008), this randomized controlled trial evaluating 12 human participants investigated: Disturbed sleep is common in chronic obstructive pulmonary disease (COPD). Key clinical takeaway: We conclude that melatonin can improve sleep in COPD. Further long-term studies involving larger number of patients are needed before melatonin can be safely recommended for the management of sleep disturbances in these patients.

Dr. Lin (AI Evidence Lead): Statistical Endpoints & Numbers

Primary Endpoint & Quantitative Summary (Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2008-10-15; N = 12; Rigor 88/100): We conclude that melatonin can improve sleep in COPD. Further long-term studies involving larger number of patients are needed before melatonin can be safely recommended for the management of sleep disturbances in these patients.

Study Limitations & Caveats Before You Act

Clinical trials evaluate specific inclusion/exclusion cohorts under protocol-controlled conditions (Randomized Controlled Trial). Individual response, hepatic/renal clearance, CYP450 drug interactions, and baseline comorbidities vary; verify applicability with a board-certified physician before modifying any prescription or supplement regimen.

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