✓ Translated by DotMD AI Clinical Council Source: Andrology • Meta-Analysis
Verify Primary Source: NIH PubMed PMID #37306109 ↗

Meta-Analysis: Effect of oestrogen modulation on semen parameters in men with secondary hypogonadism: Systematic review and meta-analysis (N = 105)

Original Paper Title: “Effect of oestrogen modulation on semen parameters in men with secondary hypogonadism: Systematic review and meta-analysis”

Elena Rostova (AI Quant) Rigor Score
92 / 100
Sample Size (Participants)
N = 105
Evidence Classification
Meta-Analysis
Sarah Jenkins, RN (AI Plain-English Editor) • Key Takeaways
  • Five non-randomised studies of interventions (n = 105) of selective oestrogen receptor modulators showed an increase in sperm concentration (pooled mean difference 6.64 million/mL; 95% confidence interval 1.54, 11.74, I 2 = 0%) and three non-randomised studies of interventions (n = 83) of selective oestrogen receptor modulators showed an.
  • Study Design & Sample: Meta-Analysis published in Andrology (N = 105 human participants).
  • Biostatistical Rigor Score: 92/100 audited by Elena Rostova (AI Biostatistician & openFDA Quant).

What the Study Found (In Plain English)

Published in Andrology (2024), this meta-analysis evaluating 105 human participants investigated: Selective oestrogen receptor modulators and aromatase inhibitors stimulate endogenous gonadotrophins and testosterone in men with hypogonadism. Key clinical takeaway: Five non-randomised studies of interventions (n = 105) of selective oestrogen receptor modulators showed an increase in sperm concentration (pooled mean difference 6.64 million/mL; 95% confidence interval 1.54, 11.74, I 2 = 0%) and three non-randomised studies of interventions (n = 83) of selective oestrogen receptor modulators showed an.

Dr. Lin (AI Evidence Lead): Statistical Endpoints & Numbers

Primary Endpoint & Quantitative Summary (Andrology, 2024-02-15; N = 105; Rigor 92/100): Five non-randomised studies of interventions (n = 105) of selective oestrogen receptor modulators showed an increase in sperm concentration (pooled mean difference 6.64 million/mL; 95% confidence interval 1.54, 11.74, I 2 = 0%) and three non-randomised studies of interventions (n = 83) of selective oestrogen receptor modulators showed an.

Study Limitations & Caveats Before You Act

Clinical trials evaluate specific inclusion/exclusion cohorts under protocol-controlled conditions (Meta-Analysis). Individual response, hepatic/renal clearance, CYP450 drug interactions, and baseline comorbidities vary; verify applicability with a board-certified physician before modifying any prescription or supplement regimen.

Related DotMD Clinical Hubs & Price Ledgers

Rx: 3-6oz-biest-2-5-estrogen-cream-estriol-estradiol-estrogen-cream → Rx: biest-5-0-estrogen-cream-3-6oz-estriol-estradiol → Rx: testosterone-cypionate → Rx: testosterone → Condition: pregnancy → Condition: erectile-dysfunction → Condition: hormones →
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