✓ Translated by DotMD AI Clinical Council Source: European journal of clinical nutrition • Randomized Controlled Trial
Verify Primary Source: NIH PubMed PMID #38866976 ↗

Randomized Controlled Trial: Effect of time restricted eating versus daily calorie restriction on sex hormones in males and females with obesity (N = 90)

Original Paper Title: “Effect of time restricted eating versus daily calorie restriction on sex hormones in males and females with obesity”

Elena Rostova (AI Quant) Rigor Score
82 / 100
Sample Size (Participants)
N = 90
Evidence Classification
Randomized Controlled Trial
Sarah Jenkins, RN (AI Plain-English Editor) • Key Takeaways
  • Estradiol, estrone, and progesterone were only measured in postmenopausal females, and remained unchanged. These findings suggest that TRE produces significant weight loss but does not impact circulating sex hormone levels in males and females with obesity over 12 months, relative to CR and controls.
  • Study Design & Sample: Randomized Controlled Trial published in European journal of clinical nutrition (N = 90 human participants).
  • Biostatistical Rigor Score: 82/100 audited by Elena Rostova (AI Biostatistician & openFDA Quant).

What the Study Found (In Plain English)

Published in European journal of clinical nutrition (2024), this randomized controlled trial evaluating 90 human participants investigated: This study examined the effects of time restricted eating (TRE) on sex hormones in males and females, versus daily calorie restriction (CR). Key clinical takeaway: Estradiol, estrone, and progesterone were only measured in postmenopausal females, and remained unchanged. These findings suggest that TRE produces significant weight loss but does not impact circulating sex hormone levels in males and females with obesity over 12 months, relative to CR and controls.

Dr. Lin (AI Evidence Lead): Statistical Endpoints & Numbers

Primary Endpoint & Quantitative Summary (European journal of clinical nutrition, 2024-09-15; N = 90; Rigor 82/100): Estradiol, estrone, and progesterone were only measured in postmenopausal females, and remained unchanged. These findings suggest that TRE produces significant weight loss but does not impact circulating sex hormone levels in males and females with obesity over 12 months, relative to CR and controls.

Study Limitations & Caveats Before You Act

Clinical trials evaluate specific inclusion/exclusion cohorts under protocol-controlled conditions (Randomized Controlled Trial). Individual response, hepatic/renal clearance, CYP450 drug interactions, and baseline comorbidities vary; verify applicability with a board-certified physician before modifying any prescription or supplement regimen.

Related DotMD Clinical Hubs & Price Ledgers

Rx: testosterone-cypionate → Rx: testosterone → Rx: progesterone → Rx: estradiol-vaginal-cream → Condition: hormones → Condition: menopause →
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