✓ Translated by DotMD AI Clinical Council Source: Journal of cardiovascular pharmacology and therapeutics • Meta-Analysis
Verify Primary Source: NIH PubMed PMID #29739234 ↗

Meta-Analysis: Effects of Long- and Intermediate-Acting Dihydropyridine Calcium Channel Blockers in Hypertension (N = 80,483)

Original Paper Title: “Effects of Long- and Intermediate-Acting Dihydropyridine Calcium Channel Blockers in Hypertension: A Systematic Review and Meta-Analysis of 18 Prospective, Randomized, Actively Controlled Trials”

Elena Rostova (AI Quant) Rigor Score
94 / 100
Sample Size (Participants)
N = 80,483
Evidence Classification
Meta-Analysis
Sarah Jenkins, RN (AI Plain-English Editor) • Key Takeaways
  • This study suggests that Amlodipine offers greater protection against major complications of hypertension compared to intermediate-acting dihydropyridine calcium channel blockers.
  • Study Design & Sample: Meta-Analysis published in Journal of cardiovascular pharmacology and therapeutics (N = 80483 human participants).
  • Biostatistical Rigor Score: 94/100 audited by Elena Rostova (AI Biostatistician & openFDA Quant).

What the Study Found (In Plain English)

Published in Journal of cardiovascular pharmacology and therapeutics (2018), this meta-analysis evaluating 80,483 human participants investigated: Dihydropyridine calcium channel blockers are a heterogeneous group of antihypertensive drugs. Key clinical takeaway: This study suggests that Amlodipine offers greater protection against major complications of hypertension compared to intermediate-acting dihydropyridine calcium channel blockers.

Dr. Lin (AI Evidence Lead): Statistical Endpoints & Numbers

Primary Endpoint & Quantitative Summary (Journal of cardiovascular pharmacology and therapeutics, 2018-09-15; N = 80483; Rigor 94/100): This study suggests that Amlodipine offers greater protection against major complications of hypertension compared to intermediate-acting dihydropyridine calcium channel blockers.

Study Limitations & Caveats Before You Act

Clinical trials evaluate specific inclusion/exclusion cohorts under protocol-controlled conditions (Meta-Analysis). Individual response, hepatic/renal clearance, CYP450 drug interactions, and baseline comorbidities vary; verify applicability with a board-certified physician before modifying any prescription or supplement regimen.

Related DotMD Clinical Hubs & Price Ledgers

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