✓ Translated by DotMD AI Clinical Council Source: Frontiers in endocrinology • Randomized Controlled Trial

Verify Primary Source: NIH PubMed PMID #39534260 ↗

Randomized Controlled Trial: Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus (N = 320)

Original Paper Title: “Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus”

Elena Rostova (AI Quant) Rigor Score

93 / 100

Sample Size (Participants)

N = 320

Evidence Classification

Randomized Controlled Trial

Sarah Jenkins, RN (AI Plain-English Editor) • Key Takeaways

The study revealed that magnesium, potassium, and magnesium and potassium combined had a significant effect on serum cortisol and melatonin levels (sleep hormones). In addition, supplementation significantly decreased the severity of insomnia among patients with diabetes by improving sleep duration.
Study Design & Sample: Randomized Controlled Trial published in Frontiers in endocrinology (N = 320 human participants).
Biostatistical Rigor Score: 93/100 audited by Elena Rostova (AI Biostatistician & openFDA Quant).

What the Study Found (In Plain English)

Published in Frontiers in endocrinology (2024), this randomized controlled trial evaluating 320 human participants investigated: Diabetes mellitus is a metabolic condition with hyperglycemia. Key clinical takeaway: The study revealed that magnesium, potassium, and magnesium and potassium combined had a significant effect on serum cortisol and melatonin levels (sleep hormones). In addition, supplementation significantly decreased the severity of insomnia among patients with diabetes by improving sleep duration.

Dr. Lin (AI Evidence Lead): Statistical Endpoints & Numbers

Primary Endpoint & Quantitative Summary (Frontiers in endocrinology, 2024-01-15; N = 320; Rigor 93/100): The study revealed that magnesium, potassium, and magnesium and potassium combined had a significant effect on serum cortisol and melatonin levels (sleep hormones). In addition, supplementation significantly decreased the severity of insomnia among patients with diabetes by improving sleep duration.

Study Limitations & Caveats Before You Act

Clinical trials evaluate specific inclusion/exclusion cohorts under protocol-controlled conditions (Randomized Controlled Trial). Individual response, hepatic/renal clearance, CYP450 drug interactions, and baseline comorbidities vary; verify applicability with a board-certified physician before modifying any prescription or supplement regimen.

Related DotMD Clinical Hubs & Price Ledgers

Rx: magnesium-sulfate-heptahydrate → Rx: magnesium-sulfate → Rx: hydrocortisone-acetate → Rx: hydrocortisone-valerate → Condition: diabetes → Condition: dietary-supplements → Condition: hormones →

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