✓ Translated by DotMD AI Clinical Council Source: The American journal of psychiatry • Randomized Controlled Trial

Verify Primary Source: NIH PubMed PMID #15337655 ↗

Randomized Controlled Trial: Efficacy of sertraline in a 12-week trial for generalized anxiety disorder (N = 188)

Original Paper Title: “Efficacy of sertraline in a 12-week trial for generalized anxiety disorder”

Elena Rostova (AI Quant) Rigor Score

88 / 100

Sample Size (Participants)

N = 188

Evidence Classification

Randomized Controlled Trial

Sarah Jenkins, RN (AI Plain-English Editor) • Key Takeaways

Sertraline appears to be efficacious and well tolerated in the treatment of generalized anxiety disorder.
Study Design & Sample: Randomized Controlled Trial published in The American journal of psychiatry (N = 188 human participants).
Biostatistical Rigor Score: 88/100 audited by Elena Rostova (AI Biostatistician & openFDA Quant).

What the Study Found (In Plain English)

Published in The American journal of psychiatry (2004), this randomized controlled trial evaluating 188 human participants investigated: Sertraline's efficacy and tolerability in treating generalized anxiety disorder were evaluated. Key clinical takeaway: Sertraline appears to be efficacious and well tolerated in the treatment of generalized anxiety disorder.

Dr. Lin (AI Evidence Lead): Statistical Endpoints & Numbers

Primary Endpoint & Quantitative Summary (The American journal of psychiatry, 2004-09-15; N = 188; Rigor 88/100): Sertraline appears to be efficacious and well tolerated in the treatment of generalized anxiety disorder.

Study Limitations & Caveats Before You Act

Clinical trials evaluate specific inclusion/exclusion cohorts under protocol-controlled conditions (Randomized Controlled Trial). Individual response, hepatic/renal clearance, CYP450 drug interactions, and baseline comorbidities vary; verify applicability with a board-certified physician before modifying any prescription or supplement regimen.

Related DotMD Clinical Hubs & Price Ledgers

Rx: sertraline-hcl → Rx: sertraline-hydrochloride → Condition: winter-weather-emergencies → Condition: post-traumatic-stress-disorder →

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