Reading this clinical breakthrough? See how real patients are applying these numbers in real life. Compare real-world patient outcomes, lab numbers, and doctor visit tips—100% free with a private @handle and zero login wall.
Click to Ask a Question or Post Your Experience ▾
Post to Gut, Labs & Supplements Space (15 Seconds • No Account or Email Required)
Or read existing discussions in Gut, Labs & Supplements Space →
Official NIH NLM MEDLINE / PubMed Citation • PMID: 42993769 • DOI: 10.1371/journal.pone.0362118

Efficacy of diadynamic currents versus transcutaneous electrical nerve stimulation for transcutaneous tibial nerve stimulation in subjects with overactive bladder syndrome: A double-blind randomized controlled trial.

PloS one • 2026 11 • Vol. 21 (11) : e0362118 • ISSN 1932-6203
Authors: Jaya Shanker Tedla, Sneha Latha Lalaji, Ajaya Kumar Midde, Nirmala A Papalkar, N Bindhu Priya, Devika Rani Sangadala, Ravi Shankar Reddy, Debjani Mukherjee, Ahlam Mohammed Alamri, Abdullah Suwayyid Alzahrani, Najla Awn Alhadi
Department of Medical Rehabilitation Science, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.

Verbatim Formal Study Abstract

BACKGROUND

In the traditional treatment of overactive bladder (OAB) with transcutaneous posterior tibial nerve stimulation (TTNS), physical therapists currently use only transcutaneous electrical nerve stimulation (TENS). However, the literature has commonly replaced TENS with diadynamic currents for various musculoskeletal pain syndromes. Moreover, no literature describes the use of diadynamic currents in the TTNS procedure. Therefore, our study aimed to determine the efficacy of diadynamic currents (DDC) versus TENS for TTNS in OAB Treatment.

METHODOLOGY

A randomized controlled trial was conducted among female patients with OAB aged 18-80 years. Subjects were randomly allocated to control and experimental groups. Participants in the control group received TTNS with TENS, and those in the experimental group underwent TTNS using DDC. Both groups received 8 TTNS sessions, two per week for 4 weeks. We measured pre- and post-intervention improvements using the International Consultation on Incontinence Questionnaire (ICIQ) for OAB and the ICIQ OAB Quality of Life (QOL). The study is registered with the Clinical Trials Registry of India under registration number CTRI/2025/12/099269.

RESULTS

The mean age of the included sample was 59.75 years. Pre- and post-intervention ICIQ-OAB and ICIQ-OAB QOL scores showed significant improvements in disease symptoms and quality of life among patients with OAB in both the control and experimental groups. Comparison of improvements between the two groups on the ICIQ questionnaires showed no significant difference (p-values of 0.87 and 0.95). Correlations between patient-related characteristics and improvements in outcome measures were also not significant.

CONCLUSION

Eight sessions of TENS and DDC, combined with conventional physical therapy, including Kegel and breathing exercises, can reduce OAB symptoms and improve QOL in subjects with OAB syndrome. Diadynamic current can be used as an adjunct to conventional TENS in TTNS for treating OAB syndrome.

Publication Classification: Journal Article Randomized Controlled Trial
NLM MeSH Descriptors: Humans Urinary Bladder, Overactive Transcutaneous Electric Nerve Stimulation Female Middle Aged Tibial Nerve Adult Aged Double-Blind Method Quality of Life Treatment Outcome Aged, 80 and over Young Adult Adolescent