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✓ Translated by DotMD AI Clinical Council Source: Journal of the American Society of Nephrology : JASN • Randomized Controlled Trial
Verify Primary Source: NIH PubMed PMID #21566054 ↗

Randomized Controlled Trial: Rosuvastatin in diabetic hemodialysis patients (N = 731)

Original Paper Title: “Rosuvastatin in diabetic hemodialysis patients”

Elena Rostova (AI Quant) Rigor Score
93 / 100
Sample Size (Participants)
N = 731
Evidence Classification
Randomized Controlled Trial
Sarah Jenkins, RN (AI Plain-English Editor) • Key Takeaways
  • Rosuvastatin treatment significantly reduced the rates of cardiac events by 32% among patients with diabetes (HR 0.68; 95% CI 0.51 to 0.90). In conclusion, among hemodialysis patients with diabetes mellitus, rosuvastatin might reduce the risk of fatal and nonfatal cardiac events.
  • Study Design & Sample: Randomized Controlled Trial published in Journal of the American Society of Nephrology : JASN (N = 731 human participants).
  • Biostatistical Rigor Score: 93/100 audited by Elena Rostova (AI Biostatistician & openFDA Quant).

What the Study Found (In Plain English)

Published in Journal of the American Society of Nephrology : JASN (2011), this randomized controlled trial evaluating 731 human participants investigated: A randomized, placebo-controlled trial in diabetic patients receiving hemodialysis showed no effect of atorvastatin on a composite cardiovascular endpoint, but analysis of the component cardiac endpoints suggested that atorvastatin may significantly reduce risk. Key clinical takeaway: Rosuvastatin treatment significantly reduced the rates of cardiac events by 32% among patients with diabetes (HR 0.68; 95% CI 0.51 to 0.90). In conclusion, among hemodialysis patients with diabetes mellitus, rosuvastatin might reduce...

Dr. Lin (AI Evidence Lead): Statistical Endpoints & Numbers

Primary Endpoint & Quantitative Summary (Journal of the American Society of Nephrology : JASN, 2011-07-15; N = 731; Rigor 93/100): Rosuvastatin treatment significantly reduced the rates of cardiac events by 32% among patients with diabetes (HR 0.68; 95% CI 0.51 to 0.90). In conclusion, among hemodialysis patients with diabetes mellitus, rosuvastatin might reduce the risk of fatal and nonfatal cardiac events.

Study Limitations & Caveats Before You Act

Clinical trials evaluate specific inclusion/exclusion cohorts under protocol-controlled conditions (Randomized Controlled Trial). Individual response, hepatic/renal clearance, CYP450 drug interactions, and baseline comorbidities vary; verify applicability with a board-certified physician before modifying any prescription or supplement regimen.

Related DotMD Clinical Hubs & Price Ledgers

Rx: rosuvastatin-calcium → Rx: rosuvastatin → Condition: diabetes → Condition: diabetes-complications → Condition: dialysis →
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