✓ Translated by DotMD AI Clinical Council Source: Journal of psychopharmacology (Oxford, England) • Randomized Controlled Trial
Verify Primary Source: NIH PubMed PMID #30652941 ↗

Randomized Controlled Trial: The Concise Health Risk Tracking-Self Report: Psychometrics within a placebo-controlled antidepressant trial among depressed outpatients (N = 278)

Original Paper Title: “The Concise Health Risk Tracking-Self Report: Psychometrics within a placebo-controlled antidepressant trial among depressed outpatients”

Elena Rostova (AI Quant) Rigor Score
93 / 100
Sample Size (Participants)
N = 278
Evidence Classification
Randomized Controlled Trial
Sarah Jenkins, RN (AI Plain-English Editor) • Key Takeaways
  • Change in clinician-rated suicidal thoughts was reflected by change in both the total score and propensity factor score. These results confirm the reliability, validity, and applicability of the CHRT-SR 12 to a placebo-controlled clinical trial of depressed outpatients receiving antidepressant medication.
  • Study Design & Sample: Randomized Controlled Trial published in Journal of psychopharmacology (Oxford, England) (N = 278 human participants).
  • Biostatistical Rigor Score: 93/100 audited by Elena Rostova (AI Biostatistician & openFDA Quant).

What the Study Found (In Plain English)

Published in Journal of psychopharmacology (Oxford, England) (2019), this randomized controlled trial evaluating 278 human participants investigated: While substantial prior research has evaluated the psychometric properties of the 12-item Concise Health Risk Tracking-Self Report (CHRT-SR 12 ), a measure of suicide propensity and suicidal thoughts, no prior research has investigated its factor structure, sensitivity to change over time, and other psychometric properties in a placebo-controlled trial of antidepressant medication, nor determined whether symptoms change throughout treatment. Key clinical takeaway: Change in clinician-rated suicidal thoughts was reflected...

Dr. Lin (AI Evidence Lead): Statistical Endpoints & Numbers

Primary Endpoint & Quantitative Summary (Journal of psychopharmacology (Oxford, England), 2019-02-15; N = 278; Rigor 93/100): Change in clinician-rated suicidal thoughts was reflected by change in both the total score and propensity factor score. These results confirm the reliability, validity, and applicability of the CHRT-SR 12 to a placebo-controlled clinical trial of depressed outpatients receiving antidepressant medication.

Study Limitations & Caveats Before You Act

Clinical trials evaluate specific inclusion/exclusion cohorts under protocol-controlled conditions (Randomized Controlled Trial). Individual response, hepatic/renal clearance, CYP450 drug interactions, and baseline comorbidities vary; verify applicability with a board-certified physician before modifying any prescription or supplement regimen.

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