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Depression, Bipolar & Mood Disorders • ICD-10-CM F31.76

Bipolar disorder, in full remission, most recent episode depressed

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM F31.76 • 7 Linked .gov / PubMed Citations • Governance: Dr. Hannah Lindqvist, MD, PhD (NPI #1457952647)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Bipolar disorder, in full remission, most recent episode depressed Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

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What Is Bipolar disorder, in full remission, most recent episode depressed?

Designated in federal medical registries as F31.76, Bipolar disorder, in full remission, most recent episode depressed falls under Depression & Mood management, where validated longitudinal mood in Bipolar disorder, in full remission, most recent episode depressed (F31.76: rating scales (PHQ-9) establishes baseline severity and rules out diagnostic mimics.

Pathophysiology, Underlying Causes & Clinical Presentation

Tissue-level etiology in Bipolar disorder, in full remission, most recent episode depressed (F31.76) features circadian phase instability [Bipolar disorder, in full remission, most recent episode depressed F31.76]. therapeutic stabilization in depression & mood is verified against TSH & Free in Bipolar disorder, in full remission, most recent episode depressed (F31.76: T4 Rule-Out).

Common Symptoms & Clinical Signs

  • • Presentation of Bipolar disorder, in full remission, most recent episode depressed (F31.76): slowed concentration, indecisiveness, in Bipolar disorder, in full remission, most recent episode depressed (F31.76: and physical heaviness)
  • • Secondary Bipolar disorder, in full remission, most recent episode depressed clinical sign: loss of interest in Bipolar disorder, in full remission, most recent episode depressed (F31.76: or pleasure in)
  • • Symptom flares in Bipolar disorder, in full remission, most recent episode depressed correlating with PHQ-9 Symptom Severity in Bipolar disorder, in full remission, most recent episode depressed (F31.76: Score) deviation outside < 4 (clinical remission) (F31.76)
  • • Functional depression & mood impact requiring validated longitudinal mood in Bipolar disorder, in full remission, most recent episode depressed (F31.76: rating scales (PHQ-9) evaluation (F31.76)

Bipolar disorder, in full remission, most recent episode depressed Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code F31.76 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Depression, Bipolar & Mood Disorders NLM Clinical Tables
Diagnostic / Lab Marker: PHQ-9 Symptom Severity in Bipolar disorder, in full remission, most recent episode depressed (F31.76: Score) < 4 (clinical remission) (F31.76) Clinical Reference Target Range
Diagnostic / Lab Marker: TSH & Free in Bipolar disorder, in full remission, most recent episode depressed (F31.76: T4 Rule-Out) TSH 0.8 – 2.5 mIU/L (F31.76) Clinical Reference Target Range
Diagnostic / Lab Marker: Serum Vitamin D in Bipolar disorder, in full remission, most recent episode depressed (F31.76: & RBC Folate) 25(OH)D 40 – 65 ng/mL (F31.76) Clinical Reference Target Range
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Peer-Reviewed Human Clinical Trials & Meta-Analyses (Bipolar disorder, in full remission, most recent episode depressed)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Concise Health Risk Tracking-Self Report: Psychometrics within a compared against: What a 278-Participant Study Found

Change in clinician-rated suicidal thoughts was reflected.

Journal of psychopharmacology (Oxford, England) • 2019-02-15 • Randomized Controlled Trial
N = 278 93/100 PMID 30652941 ↗
New Insights on Improvements in irritability with sertraline versus placebo: Findings from the: What a 292-Participant Study Found

There was a significant treatment arm-by-time interaction (F = 6.96, df = 6, 1418, p <0.0001) suggesting that changes in irritability with sertraline differed from placebo.

Journal of affective disorders • 2020-10-01 • Randomized Controlled Trial
N = 292 93/100 PMID 32658822 ↗
New Insights on Efficacy of Lumateperone in Patients With Bipolar Depression With Mixed: What a 376-Participant Study Found

Conclusions: Lumateperone 42 mg significantly improved symptoms of depression and disease severity in patients with an MDE associated with bipolar I or bipolar II disorder, with or without mixed features.

The Journal of clinical psychiatry • 2023-04-24 • Phase III Randomized Trial
N = 376 93/100 PMID 37103915 ↗
New Insights on Can personalized treatment prediction improve the outcomes, compared with the: What a 1,544-Participant Study Found

The multivariable prediction models led to improved recommendations for a minority of participants than the group average approach in a megatrial.

Journal of affective disorders • 2020-09-01 • Randomized Controlled Trial
N = 1,544 90/100 PMID 32664003 ↗
Can This Approach Help? Inside the Latest Research on Duration of Adjunctive Antidepressant Maintenance in Bipolar I

In a trial involving patients with bipolar I disorder and a recently remitted depressive episode, adjunctive treatment with escitalopram or bupropion XL that continued for 52 weeks did not show a significant benefit as...

The New England journal of medicine • 2023-08-03 • Randomized Controlled Trial
N = 90 88/100 PMID 37530824 ↗
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