✓ Translated by DotMD AI Clinical Council Source: The international journal of neuropsychopharmacology • Randomized Controlled Trial
Verify Primary Source: NIH PubMed PMID #18611293 ↗

Randomized Controlled Trial: What predicts attrition in second step medication treatments for depression?: a STAR*D Report (N = 563)

Original Paper Title: “What predicts attrition in second step medication treatments for depression?: a STAR*D Report”

Elena Rostova (AI Quant) Rigor Score
87 / 100
Sample Size (Participants)
N = 563
Evidence Classification
Randomized Controlled Trial
Sarah Jenkins, RN (AI Plain-English Editor) • Key Takeaways
  • Minority status, younger age, and greater difficulty with the first treatment step are risk factors for attrition in the second treatment step. Focus on patients with attrition risk factors for medication augmentation or switch strategies may enhance retention and improve outcomes.
  • Study Design & Sample: Randomized Controlled Trial published in The international journal of neuropsychopharmacology (N = 563 human participants).
  • Biostatistical Rigor Score: 87/100 audited by Elena Rostova (AI Biostatistician & openFDA Quant).

What the Study Found (In Plain English)

Published in The international journal of neuropsychopharmacology (2009), this randomized controlled trial evaluating 563 human participants investigated: Attrition rates are high during treatment for major depressive disorder (MDD), and patients who drop out are less likely to reach remission. Key clinical takeaway: Minority status, younger age, and greater difficulty with the first treatment step are risk factors for attrition in the second treatment step. Focus on patients with attrition risk factors for medication augmentation or switch strategies may enhance retention and improve outcomes.

Dr. Lin (AI Evidence Lead): Statistical Endpoints & Numbers

Primary Endpoint & Quantitative Summary (The international journal of neuropsychopharmacology, 2009-05-15; N = 563; Rigor 87/100): Minority status, younger age, and greater difficulty with the first treatment step are risk factors for attrition in the second treatment step. Focus on patients with attrition risk factors for medication augmentation or switch strategies may enhance retention and improve outcomes.

Study Limitations & Caveats Before You Act

Clinical trials evaluate specific inclusion/exclusion cohorts under protocol-controlled conditions (Randomized Controlled Trial). Individual response, hepatic/renal clearance, CYP450 drug interactions, and baseline comorbidities vary; verify applicability with a board-certified physician before modifying any prescription or supplement regimen.

Related DotMD Clinical Hubs & Price Ledgers

Rx: bupropion-xl → Rx: bupropion-hydrochloride → Rx: buspirone-hcl → Rx: buspirone-hydrochloride → Condition: depression → Condition: bipolar-disorder-in-full-remission-most-recent-episode-hypomanic → Condition: bipolar-disorder-in-partial-remission-most-recent-episode-manic →
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