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Depression, Bipolar & Mood Disorders • ICD-10-CM F31.73

Bipolar disorder, in partial remission, most recent episode manic

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM F31.73 • 7 Linked .gov / PubMed Citations • Governance: Dr. Hannah Lindqvist, MD, PhD (NPI #1457952647)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Bipolar disorder, in partial remission, most recent episode manic Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Bipolar disorder, in partial remission, most recent episode manic?

Physicians managing Bipolar disorder, in partial remission, most recent episode manic (F31.73; Depression, Bipolar & Mood Disorders) utilize sleep-wake rhythm assessment [Bipolar disorder, in partial remission, most recent episode manic F31.73] and objective Serum Vitamin D in Bipolar disorder, in partial remission, most recent episode manic (F31.73: & RBC Folate) targets (25(OH)D 40 – 65 ng/mL (F31.73)) to prevent progression and functional morbidity.

Pathophysiology, Underlying Causes & Clinical Presentation

Pathophysiologically, Bipolar disorder, in partial remission, most recent episode manic (ICD-10 F31.73) is driven by norepinephrine [Bipolar disorder, in partial remission, most recent episode manic F31.73]; specialists in Depression, Bipolar & Mood Disorders monitor PHQ-9 Symptom Severity in Bipolar disorder, in partial remission, most recent episode manic (F31.73: Score) to gauge tissue recovery.

Common Symptoms & Clinical Signs

  • • Presentation of Bipolar disorder, in partial remission, most recent episode manic (F31.73): disrupted sleep architecture [Bipolar disorder, in partial remission, most recent episode manic F31.73]
  • • Secondary Bipolar disorder, in partial remission, most recent episode manic clinical sign: slowed concentration, indecisiveness, in Bipolar disorder, in partial remission, most recent episode manic (F31.73: and physical heaviness)
  • • Symptom flares in Bipolar disorder, in partial remission, most recent episode manic correlating with Serum Vitamin D in Bipolar disorder, in partial remission, most recent episode manic (F31.73: & RBC Folate) deviation outside 25(OH)D 40 – 65 ng/mL (F31.73)
  • • Functional depression & mood impact requiring sleep-wake rhythm assessment [Bipolar disorder, in partial remission, most recent episode manic F31.73] evaluation (F31.73)

Bipolar disorder, in partial remission, most recent episode manic Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code F31.73 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Depression, Bipolar & Mood Disorders NLM Clinical Tables
Diagnostic / Lab Marker: Serum Vitamin D in Bipolar disorder, in partial remission, most recent episode manic (F31.73: & RBC Folate) 25(OH)D 40 – 65 ng/mL (F31.73) Clinical Reference Target Range
Diagnostic / Lab Marker: PHQ-9 Symptom Severity in Bipolar disorder, in partial remission, most recent episode manic (F31.73: Score) < 4 (clinical remission) (F31.73) Clinical Reference Target Range
Diagnostic / Lab Marker: TSH & Free in Bipolar disorder, in partial remission, most recent episode manic (F31.73: T4 Rule-Out) TSH 0.8 – 2.5 mIU/L (F31.73) Clinical Reference Target Range
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Peer-Reviewed Human Clinical Trials & Meta-Analyses (Bipolar disorder, in partial remission, most recent episode manic)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Efficacy of Lumateperone in Patients With Bipolar Depression With Mixed: What a 376-Participant Study Found

Conclusions: Lumateperone 42 mg significantly improved symptoms of depression and disease severity in patients with an MDE associated with bipolar I or bipolar II disorder, with or without mixed features.

The Journal of clinical psychiatry • 2023-04-24 • Phase III Randomized Trial
N = 376 93/100 PMID 37103915 ↗
Can This Approach Help? Inside the Latest Research on Cortical Connectivity Moderators of Antidepressant vs Placebo Treatment Response

Of the participants recruited, 9 withdrew after first dose owing to reported adverse effects, and 221 participants (150 women; mean [SD] age, 37.8 [12.7] years) underwent EEG recordings and had high-quality pretreatment EEG data.

JAMA psychiatry • 2020-04-01 • Randomized Controlled Trial
Multi-cohort 88/100 PMID 31895437 ↗
Can This Approach Help? Inside the Latest Research on Duration of Adjunctive Antidepressant Maintenance in Bipolar I

In a trial involving patients with bipolar I disorder and a recently remitted depressive episode, adjunctive treatment with escitalopram or bupropion XL that continued for 52 weeks did not show a significant benefit as...

The New England journal of medicine • 2023-08-03 • Randomized Controlled Trial
N = 90 88/100 PMID 37530824 ↗
Can This Approach Help? Inside the Latest Research on Benefits and safety of Lumateperone for Major Depressive Episodes Associated With

Lumateperone at 42 mg/day significantly improved depression symptoms and was generally well tolerated in patients with major depressive episodes associated with both bipolar I and bipolar II disorders.

The American journal of psychiatry • 2021-12-15 • Phase III Randomized Trial
N = 188 88/100 PMID 34551584 ↗
Can This Approach Help? Inside the Latest Research on Adjunctive lumateperone (ITI-007) in the treatment of bipolar depression: Results

Lumateperone 42-mg treatment adjunctive to lithium or valproate significantly improved depression symptoms and was generally well tolerated in patients with MDEs associated with either bipolar I or bipolar II disorder.

Bipolar disorders • 2023-09-15 • Phase III Randomized Trial
N = 176 88/100 PMID 36779257 ↗
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