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Seasonal Immune Botanicals • NIH Office of Dietary Supplements (DSLD)

Black Elderberry Anthocyanin Extract (Sambucus nigra)

Active Constituents: Elderberry, Raspberry

Audited by the DotMD AI Specialist Council • NIH DSLD #24372 • 8 Linked .gov / PubMed Citations
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Black Elderberry Anthocyanin Extract (Sambucus nigra) Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

84%
Patient “Worth It” (30)
$17
Lowest Cash / Mo
Pharmacology & Clinical Trial Dosing

How Black Elderberry Anthocyanin Extract (Sambucus nigra) Works & Standard Studied Dosages

Anthocyanin-standardized Sambucus nigra berry extract used short-term at the onset of seasonal upper respiratory viral symptoms.

Cyanidin-3-glucoside flavonoids bind viral hemagglutinin surface spikes and support mucosal cytokine defense.

Typical Human Study Regimens

300 mg – 600 mg standardized extract daily during acute seasonal exposure
Dr. Vance (AI PharmD Clinical Pharmacologist)

Black Elderberry Anthocyanin Extract (Sambucus nigra) Prescription Drug Interactions & Side Effects

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Systemic Immunosuppressants Minor

Theoretical immune-stimulating antagonism in transplant/autoimmune regimens.

Reported Side Effects & Tolerability Notes

GI nausea if unripe/uncooked plant parts used (use standardized extracts only)
Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

Ask our AI Specialists anything about Black Elderberry Anthocyanin Extract (Sambucus nigra)

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Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Black Elderberry Anthocyanin Extract (Sambucus nigra))

Browse All PubMed Translations →
Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Skin-applied Efinaconazole 10% for Onychomycosis: Pooled Phase 3 Analysis in: What a 1,655-Participant Study Found

Applied to the skin efinaconazole 10% showed favorable efficacy/safety in White, Asian, and Black participants with mild-to-moderate onychomycosis.

Journal of drugs in dermatology : JDD • 2026-01-01 • Phase III Randomized Trial
N = 1,655 96/100 PMID 41493257 ↗
New Insights on Benefits and safety of darolutamide plus androgen-deprivation therapy in Black: What a 669-Participant Study Found

In Black patients from ARANOTE, darolutamide was associated with improvement in rPFS.

Prostate cancer and prostatic diseases • 2026-09-15 • Phase III Randomized Trial
N = 669 93/100 PMID 42323390 ↗
New Insights on Benefits and safety of darolutamide in Black/African-American patients from the: What a 955-Participant Study Found

The safety profile of darolutamide in Black/African-American patients was consistent with that of all ARAMIS patients.

Future oncology (London, England) • 2022-12-15 • Phase III Randomized Trial
N = 955 93/100 PMID 36753353 ↗
Can This Approach Help? Inside the Latest Research on Unripe Black Raspberry Extract Supplementation on Male Climacteric Syndrome and

In the BRE group, the total IPSS and IPSS-QoL scores decreased significantly after 12 weeks compared to baseline ( p p < 0.05).

Nutrients • 2023-07-26 • Randomized Controlled Trial
N = 30 88/100 PMID 37571251 ↗
Can This Approach Help? Inside the Latest Research on A noninferiority comparison of valsartan/hydrochlorothiazide combination versus

The proportion of patients reporting side effects and the incidence of most events were similar in both treatment groups, although more patients treated with amlodipine reported peripheral edema (5.8% versus 1.7%; P=0.03) and...

Hypertension (Dallas, Tex. : 1979) • 2005-09-15 • Randomized Controlled Trial
Multi-cohort 88/100 PMID 16116046 ↗

Black Elderberry Anthocyanin Extract (Sambucus nigra) Patient Community Discussions & 15-Second Logs

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Female • 45-59 • 300 mg – 600 mg standardized extra • Week 1032 helpful • 2 replies

Black Elderberry Anthocyanin Extract (Sambucus nigra): spacing around Systemic Immunosuppressants and third-party purity checks

Pinned FDA/PubMed Clinical Context Note • Sarah Jenkins — AI RN Plain-English Translator

FDA/PubMed Clinical Context Note: Black Elderberry Anthocyanin Extract (Sambucus nigra) (NIH DSLD Label #24372) lists Systemic Immunosuppressants (Minor interaction: Theoretical immune-stimulating antagonism in transplant/autoimmune regimens.). Verify USP, NSF, or ISO-17025 certificate-of-analysis testing.

Started Black Elderberry Anthocyanin Extract (Sambucus nigra) (300 mg – 600 mg standardized extract daily) at ~$16.50/month. Notice the interaction matrix flags Systemic Immunosuppressants. How are folks spacing morning vs. evening doses to keep absorption clean?

Female • 18-29 • Week 16

Spacing Black Elderberry Anthocyanin Extract (Sambucus nigra) at least 4 hours away from my morning medications kept my repeat blood panel completely steady with zero stomach upset.

Adult • 45-59 • Lab-Tracked

Checking the NIH DSLD active ingredient form vs. cheap oxide/filler blends was huge—paying ~$16.50/mo for the chelated/standardized form improved tolerability immediately.