Mood Botanicals (High Interaction Alert) • NIH Office of Dietary Supplements (DSLD)

Sundown Naturals St. John's Wort

Active Constituents: St. John’s Wort extract, Contains Less Than 2% of

Manic episode, severe, without psychotic symptoms (F30.13) Bipolar disorder, current episode manic without psychotic features, moderate (F31.12) Bipolar disorder, in partial remission, most recent episode hypomanic (F31.71) Other bipolar disorder (F31.89)

Audited by the DotMD AI Specialist Council • NIH DSLD #30373 • 4 Linked .gov / PubMed Citations

Methodology & AI Transparency ⓘ

Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.

At a Glance • Plain-English Clinical Summary

Sundown Naturals St. John's Wort Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

90%

Patient “Worth It” (5)

$19

Lowest Cash / Mo

1 What it does: Sundown Naturals St.
2 Real-world patient consensus: 90% community "Worth It" score across 5 anonymous Sundown Naturals St. John's Wort logs.
3 Typical cash cost range: Public price comparison for Sundown Naturals St. John's Wort: $19.42/mo at label serving.
4 Top reported side effects / signs: Verify SSRIs, SNRIs, Triptans & MAOIs spacing when taking Sundown Naturals St. John's Wort (capsule).

Pharmacology & Clinical Trial Dosing

How Sundown Naturals St. John's Wort Works & Standard Studied Dosages

Sundown Naturals St. John's Wort (DSLD #30373) represents an on-market capsule preparation containing St. John’s Wort extract, Contains Less Than 2% of, evaluated in depression & mood and mood botanicals (high interaction alert) nutritional protocols.

Metabolic uptake of St. John’s Wort extract, Contains Less Than 2% of from Sundown Naturals St. John's Wort (capsule, DSLD #30373) supports hyperforin non-selectively inhibits synaptic reuptake of serotonin.

Typical Human Study Regimens

Standard Sundown Naturals St. John's Wort capsule serving per NIH DSLD #30373 Adjust capsule timing relative to meals and concurrent prescriptions

View Official NIH Office of Dietary Supplements Fact Sheet ↗

Dr. Vance (AI PharmD Clinical Pharmacologist)

Sundown Naturals St. John's Wort Prescription Drug Interactions & Side Effects

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SSRIs, SNRIs, Triptans & MAOIs Major

Patients combining Sundown Naturals St. John's Wort (capsule) and ssris, snris, triptans & maois should verify lab stability with their prescriber.

Reported Side Effects & Tolerability Notes

Occasional mild GI fullness if Sundown Naturals St. John's Wort (capsule) is taken on an empty stomach Check NIH DSLD #30373 excipient list for Sundown Naturals capsule/binder sensitivities

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Sundown Naturals St. John's Wort)

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Human clinical trial evidence for Sundown Naturals St. John's Wort is indexed directly from the U.S. National Library of Medicine NCBI PubMed database. Explore recent randomized trials in the PubMed Research Pulse .

Sundown Naturals St. John's Wort Patient Community Discussions & 15-Second Logs

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15-Second Anonymous Micro-Log (Zero-PHI Architecture)

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“People Like Me” Cohort Filter (Zero-PHI)

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