Evidence Desk Prompt • Cash Price & Safety: Creatine, ginkgo, trazodone and sildenafil users

Creatine monohydrate has the most consistent evidence of the three for cognition in older adults, but trials are small. Typical dosing is 3-5 g/day, and a 20 g/day loading phase is not required. It can raise serum creatinine by roughly 0.1-0.3 mg/dL without changing kidney function, so tell your clinician before kidney labs. Cash prices for plain creatine monohydrate commonly run about $0.10-0.30 per 5 g serving. Ginkgo EGB 761 is more complicated: the GEM trial found no dementia prevention at 120 mg twice daily, and ginkgo may add bleeding risk or interact with trazodone. Sildenafil users should also report any new supplements. What do you pay per month for creatine, in dollars per 5 g serving? What did you track at baseline? Share your price, dose and any lab changes.