How much protein and resistance training do I need on tirzepatide to protect muscle, and is creatine safe to add?

In the SURMOUNT-1 DXA substudy, roughly a quarter of tirzepatide weight loss was lean mass. Semaglutide body-composition data (STEP 1) showed a somewhat higher lean share, about 39%. Lean mass is not all skeletal muscle, but the loss still matters. No drug label sets a protein target. Common clinical practice for adults losing weight is about 1.2-1.6 g/kg/day, with kidney disease needing individual limits. A 90 kg person would aim for roughly 110-145 g daily, split into 3-4 servings of 25-35 g. Whey protein isolate helps when appetite is low. Resistance training 2-3 days per week, working the major muscle groups close to fatigue, has the strongest evidence for preserving muscle during weight loss. Creatine monohydrate at 3-5 g/day is well studied for strength, but it can raise serum creatinine by about 0.1-0.3 mg/dL without changing true kidney function. Tell your clinician before lab draws.