★ "What Worked For Me" Outcome Report @GraniteHiker_NH • 60+M • Pantoprazole 40 mg + Mg glyc • Week 16

▲ 48 Helpful • 2 Peer Replies

Pantoprazole 40 mg + Mg glycinate evening + B12 1000 mcg (16 wks update): Background: Barrett's monitoring and long-term PPI use under specialist care, so stopping... — what worked for others here?

Background: Barrett's monitoring and long-term PPI use under specialist care, so stopping was not an option. Baseline labs: magnesium 1.5 mg/dL (my lab's range 1.7-2.2), B12 215 pg/mL, ferritin 38 ng/mL. Changes: pantoprazole 30 minutes before breakfast instead of random timing, magnesium glycinate 200 mg elemental with dinner, and oral cyanocobalamin 1000 mcg daily. Magnesium stayed under the 350 mg/day supplemental upper limit and was spaced at least 2 hours from other minerals and medications. Recheck at week 12: magnesium 1.9 mg/dL, B12 520 pg/mL. Leg cramps and night-time palpitations went away, and loose stools were minimal with glycinate. My GI continues the PPI because of Barrett's.

⚕ Pinned FDA / NIH / PubMed Clinical Context • Karim El-Sayed — Literature & Label Auditor

NIH ODS lists the adult supplemental magnesium upper limit at 350 mg/day and the B12 RDA at 2.4 mcg/day, with B12 under 200 pg/mL considered deficient. FDA DailyMed pantoprazole labeling warns about hypomagnesemia and B12 deficiency with prolonged use.

Connected Clinical Guides: Condition: Gastroesophageal Reflux Disease Condition: Irritable Bowel Syndrome Rx: Omeprazole Rx: Pantoprazole Supplement: Magnesium Glycinate Supplement: Vitamin B12

Find Gastroenterologists (CPT 45378 / 43239) →

Verified Peer Replies (2)

@LowPurineChef_FL • Verified Cohort Member • Week 22

Useful report. Reminder: magnesium supplements are cleared by the kidneys, so check eGFR first, and separate magnesium from other medications that bind minerals (some antibiotics, levothyroxine) by about 2-4 hours. Recheck magnesium within 8-12 weeks of any change.

@GreatLakesKayak_MI • Age 45-59 • Week 14

Same pattern for me with B12 at 240 pg/mL. I take 1000 mcg sublingual daily and recheck every 6 months. Magnesium glycinate at night also improved my sleep. I check with my pharmacist before adding any other supplement.