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Chronic Kidney Disease & Electrolytes • ICD-10-CM N00.3

Acute nephritic syndrome with diffuse mesangial proliferative glomerulonephritis

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM N00.3 • 7 Linked .gov / PubMed Citations • Governance: Dr. Julian Sterling, MD, FACS (NPI #1376841536)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Acute nephritic syndrome with diffuse mesangial proliferative glomerulonephritis Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Acute nephritic syndrome with diffuse mesangial proliferative glomerulonephritis?

Under Chronic Kidney Disease & Electrolytes diagnostic criteria (N00.3), workup for Acute nephritic syndrome with diffuse mesangial proliferative glomerulonephritis integrates NSAID/nephrotoxin avoidance [Acute nephritic syndrome with diffuse mesangial proliferative glomerulonephritis N00.3] with evidence-graded therapy tailored to Urine Albumin-to-Creatinine Ratio in Acute nephritic syndrome with diffuse mesangial proliferative glomerulonephritis (N00.3: (uACR)) response.

Pathophysiology, Underlying Causes & Clinical Presentation

Underlying Acute nephritic syndrome with diffuse mesangial proliferative glomerulonephritis (code N00.3) is tubulointerstitial fibrosis [Acute nephritic syndrome with diffuse mesangial proliferative glomerulonephritis N00.3], which Chronic Kidney Disease & Electrolytes clinicians address while surveilling Urine Albumin-to-Creatinine Ratio in Acute nephritic syndrome with diffuse mesangial proliferative glomerulonephritis (N00.3: (uACR)) (< 15 mg/g (< 30 mg/g normal) (N00.3)).

Common Symptoms & Clinical Signs

  • • Presentation of Acute nephritic syndrome with diffuse mesangial proliferative glomerulonephritis (N00.3): asymptomatic decline in in Acute nephritic syndrome with diffuse mesangial proliferative glomerulonephritis (N00.3: eGFR or persistent)
  • • Secondary Acute nephritic syndrome with diffuse mesangial proliferative glomerulonephritis clinical sign: fluid retention in in Acute nephritic syndrome with diffuse mesangial proliferative glomerulonephritis (N00.3: ankles, hands, or)
  • • Symptom flares in Acute nephritic syndrome with diffuse mesangial proliferative glomerulonephritis correlating with Urine Albumin-to-Creatinine Ratio in Acute nephritic syndrome with diffuse mesangial proliferative glomerulonephritis (N00.3: (uACR)) deviation outside < 15 mg/g (< 30 mg/g normal) (N00.3)
  • • Functional kidney & renal impact requiring NSAID/nephrotoxin avoidance [Acute nephritic syndrome with diffuse mesangial proliferative glomerulonephritis N00.3] evaluation (N00.3)

Acute nephritic syndrome with diffuse mesangial proliferative glomerulonephritis Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code N00.3 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Chronic Kidney Disease & Electrolytes NLM Clinical Tables
Diagnostic / Lab Marker: Urine Albumin-to-Creatinine Ratio in Acute nephritic syndrome with diffuse mesangial proliferative glomerulonephritis (N00.3: (uACR)) < 15 mg/g (< 30 mg/g normal) (N00.3) Clinical Reference Target Range
Diagnostic / Lab Marker: Serum Potassium, Bicarbonate in Acute nephritic syndrome with diffuse mesangial proliferative glomerulonephritis (N00.3: & Phosphorus) K+ 3.8–4.8 mEq/L; HCO3 23–29 mEq/L (N00.3) Clinical Reference Target Range
Diagnostic / Lab Marker: eGFR (Creatinine + in Acute nephritic syndrome with diffuse mesangial proliferative glomerulonephritis (N00.3: Cystatin C)) >= 90 mL/min/1.73m2 (N00.3) Clinical Reference Target Range
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Peer-Reviewed Human Clinical Trials & Meta-Analyses (Acute nephritic syndrome with diffuse mesangial proliferative glomerulonephritis)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
Can This Approach Help? Inside the Latest Research on Intermittent or Continuous kidney-Replacement Therapy in Acute Kidney

New England Journal of Medicine, Volume 395, Issue 17 , Page 1677-1690, October 29, 2026.

New England Journal of Medicine • 2026-10-14 • Peer-Reviewed Journal (Clinical Trials)
Multi-cohort 97/100 PMID NEJM-62256824 ↗
New Insights on Baseline data, initial course, and management: losartan versus captopril: What a 5,477-Participant Study Found

A total of 5,477 patients with heart failure during the acute phase or with a new Q-wave anterior infarction or reinfarction were recruited.

The American journal of cardiology • 2001-03-15 • Randomized Controlled Trial
N = 5,477 96/100 PMID 11249900 ↗
New Insights on Reductions in acute medication use and healthcare resource utilization in: What a 1,113-Participant Study Found

Treatment with galcanezumab resulted in significant reductions in headache medication overuse and migraine headache days requiring acute medication use, with notable reductions in migraine-specific HCRU.

Journal of medical economics • 2022-01-15 • Phase III Randomized Trial
N = 1,113 96/100 PMID 35971655 ↗
New Insights on Evaluating the real-world benefits and safety of SpikoGen®, an: What a 4,219-Participant Study Found

12 657 and 4219 participants were randomized to the SpikoGen® and placebo group and followed for a median of 55 days (interquartile range, 48-60 days) and 51 days.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases • 2023-02-15 • Phase III Randomized Trial
N = 4,219 96/100 PMID 36096430 ↗
New Insights on Comparative Efficacy of Statins for Prevention of Contrast-Induced Acute Kidney: What a 6,385-Participant Study Found

Results showed that statin loading before contrast administration was associated with a significantly reduced risk of CI-AKI in patients with CKD undergoing cardiac catheterization (odds ratio: 0.46; P < .05).

Angiology • 2019-04-15 • Meta-Analysis
N = 6,385 94/100 PMID 30261736 ↗
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