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Depression, Bipolar & Mood Disorders • ICD-10-CM F31.10

Bipolar disorder, current episode manic without psychotic features

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM F31.10 • 7 Linked .gov / PubMed Citations • Governance: Dr. Hannah Lindqvist, MD, PhD (NPI #1457952647)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Bipolar disorder, current episode manic without psychotic features Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

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What Is Bipolar disorder, current episode manic without psychotic features?

Under Depression, Bipolar & Mood Disorders diagnostic criteria (F31.10), workup for Bipolar disorder, current episode manic without psychotic features integrates sleep-wake rhythm assessment [Bipolar disorder, current episode manic without psychotic features F31.10] with evidence-graded therapy tailored to PHQ-9 Symptom Severity in Bipolar disorder, current episode manic without psychotic features (F31.10: Score) response.

Pathophysiology, Underlying Causes & Clinical Presentation

In Bipolar disorder, current episode manic without psychotic features (F31.10), physiological disruption stems from dopamine) signaling imbalance [Bipolar disorder, current episode manic without psychotic features F31.10], informing Depression, Bipolar & Mood Disorders protocols that track TSH & Free in Bipolar disorder, current episode manic without psychotic features (F31.10: T4 Rule-Out) (TSH 0.8 – 2.5 mIU/L (F31.10)).

Common Symptoms & Clinical Signs

  • • Presentation of Bipolar disorder, current episode manic without psychotic features (F31.10): loss of interest in Bipolar disorder, current episode manic without psychotic features (F31.10: or pleasure in)
  • • Secondary Bipolar disorder, current episode manic without psychotic features clinical sign: persistent low mood, in Bipolar disorder, current episode manic without psychotic features (F31.10: emotional flatness, or)
  • • Symptom flares in Bipolar disorder, current episode manic without psychotic features correlating with PHQ-9 Symptom Severity in Bipolar disorder, current episode manic without psychotic features (F31.10: Score) deviation outside < 4 (clinical remission) (F31.10)
  • • Functional depression & mood impact requiring sleep-wake rhythm assessment [Bipolar disorder, current episode manic without psychotic features F31.10] evaluation (F31.10)

Bipolar disorder, current episode manic without psychotic features Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code F31.10 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Depression, Bipolar & Mood Disorders NLM Clinical Tables
Diagnostic / Lab Marker: PHQ-9 Symptom Severity in Bipolar disorder, current episode manic without psychotic features (F31.10: Score) < 4 (clinical remission) (F31.10) Clinical Reference Target Range
Diagnostic / Lab Marker: TSH & Free in Bipolar disorder, current episode manic without psychotic features (F31.10: T4 Rule-Out) TSH 0.8 – 2.5 mIU/L (F31.10) Clinical Reference Target Range
Diagnostic / Lab Marker: Serum Vitamin D in Bipolar disorder, current episode manic without psychotic features (F31.10: & RBC Folate) 25(OH)D 40 – 65 ng/mL (F31.10) Clinical Reference Target Range
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Peer-Reviewed Human Clinical Trials & Meta-Analyses (Bipolar disorder, current episode manic without psychotic features)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Efficacy of Lumateperone in Patients With Bipolar Depression With Mixed: What a 376-Participant Study Found

Conclusions: Lumateperone 42 mg significantly improved symptoms of depression and disease severity in patients with an MDE associated with bipolar I or bipolar II disorder, with or without mixed features.

The Journal of clinical psychiatry • 2023-04-24 • Phase III Randomized Trial
N = 376 93/100 PMID 37103915 ↗
New Insights on Depression Subtypes in Predicting Antidepressant Response: A Report From the: What a 1,008-Participant Study Found

There was substantial overlap of the three depressive subtypes, and individuals in all subtype groups responded similarly to the three.

The American journal of psychiatry • 2015-08-01 • Randomized Controlled Trial
N = 1,008 90/100 PMID 25815419 ↗
Can This Approach Help? Inside the Latest Research on Duration of Adjunctive Antidepressant Maintenance in Bipolar I

In a trial involving patients with bipolar I disorder and a recently remitted depressive episode, adjunctive treatment with escitalopram or bupropion XL that continued for 52 weeks did not show a significant benefit as...

The New England journal of medicine • 2023-08-03 • Randomized Controlled Trial
N = 90 88/100 PMID 37530824 ↗
Can This Approach Help? Inside the Latest Research on A Trial of Sertraline or Cognitive Behavior Therapy for Depression in

Depression remitted in just over one-half of subjects following sertraline or CBT.

Annals of neurology • 2019-10-15 • Randomized Controlled Trial
Multi-cohort 88/100 PMID 31359460 ↗
Can This Approach Help? Inside the Latest Research on Efficacy of escitalopram in depression: a multicenter randomized, compared

SDS and VAS-P1 both decreased after treatment with generic escitalopram or proprietary escitalopram Lexapro.

International clinical psychopharmacology • 2021-05-01 • Randomized Controlled Trial
Multi-cohort 88/100 PMID 33779577 ↗
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