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Depression, Bipolar & Mood Disorders • ICD-10-CM F31.60

Bipolar disorder, current episode mixed

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM F31.60 • 7 Linked .gov / PubMed Citations • Governance: Dr. Hannah Lindqvist, MD, PhD (NPI #1457952647)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Bipolar disorder, current episode mixed Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

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What Is Bipolar disorder, current episode mixed?

Physicians managing Bipolar disorder, current episode mixed (F31.60; Depression, Bipolar & Mood Disorders) utilize structured psychiatric history [Bipolar disorder, current episode mixed F31.60] and objective TSH & Free in Bipolar disorder, current episode mixed (F31.60: T4 Rule-Out) targets (TSH 0.8 – 2.5 mIU/L (F31.60)) to prevent progression and functional morbidity.

Pathophysiology, Underlying Causes & Clinical Presentation

At the cellular and tissue level in depression & mood, Bipolar disorder, current episode mixed (F31.60) involves norepinephrine [Bipolar disorder, current episode mixed F31.60]. progression correlates with shifts in TSH & Free in Bipolar disorder, current episode mixed (F31.60: T4 Rule-Out) (TSH 0.8 – 2.5 mIU/L (F31.60)).

Common Symptoms & Clinical Signs

  • • Presentation of Bipolar disorder, current episode mixed (F31.60): disrupted sleep architecture [Bipolar disorder, current episode mixed F31.60]
  • • Secondary Bipolar disorder, current episode mixed clinical sign: slowed concentration, indecisiveness, in Bipolar disorder, current episode mixed (F31.60: and physical heaviness)
  • • Symptom flares in Bipolar disorder, current episode mixed correlating with TSH & Free in Bipolar disorder, current episode mixed (F31.60: T4 Rule-Out) deviation outside TSH 0.8 – 2.5 mIU/L (F31.60)
  • • Functional depression & mood impact requiring structured psychiatric history [Bipolar disorder, current episode mixed F31.60] evaluation (F31.60)

Bipolar disorder, current episode mixed Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code F31.60 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Depression, Bipolar & Mood Disorders NLM Clinical Tables
Diagnostic / Lab Marker: TSH & Free in Bipolar disorder, current episode mixed (F31.60: T4 Rule-Out) TSH 0.8 – 2.5 mIU/L (F31.60) Clinical Reference Target Range
Diagnostic / Lab Marker: Serum Vitamin D in Bipolar disorder, current episode mixed (F31.60: & RBC Folate) 25(OH)D 40 – 65 ng/mL (F31.60) Clinical Reference Target Range
Diagnostic / Lab Marker: PHQ-9 Symptom Severity in Bipolar disorder, current episode mixed (F31.60: Score) < 4 (clinical remission) (F31.60) Clinical Reference Target Range
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Peer-Reviewed Human Clinical Trials & Meta-Analyses (Bipolar disorder, current episode mixed)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Effect of Esketamine Nasal Spray on Cognition in Patients With: What a 747-Participant Study Found

This analysis did not identify evidence of negative effects on cognition following short-term or long-term maintenance treatment with ESK+OAD in patients with TRD.

The international journal of neuropsychopharmacology • 2024-11-01 • Phase III Randomized Trial
N = 747 93/100 PMID 39514643 ↗
New Insights on Efficacy of Lumateperone in Patients With Bipolar Depression With Mixed: What a 376-Participant Study Found

Conclusions: Lumateperone 42 mg significantly improved symptoms of depression and disease severity in patients with an MDE associated with bipolar I or bipolar II disorder, with or without mixed features.

The Journal of clinical psychiatry • 2023-04-24 • Phase III Randomized Trial
N = 376 93/100 PMID 37103915 ↗
Can This Approach Help? Inside the Latest Research on Staying on track with medication to antidepressant combinations and single-drug

With closely monitored treatment, skipping doses is low and unrelated to depressive symptom outcome.

Journal of psychiatric practice • 2014-03-15 • Randomized Controlled Trial
Multi-cohort 88/100 PMID 24638046 ↗
Can This Approach Help? Inside the Latest Research on Gold-standard blind, randomized, compared against a dummy pill (placebo) pilot

CLS is safe and effective short-term add-on treatment in patients with MDD with no other comorbid conditions.

CNS neuroscience & therapeutics • 2021-12-15 • Randomized Controlled Trial
N = 80 88/100 PMID 34545997 ↗
Can This Approach Help? Inside the Latest Research on Reflections of depression in acoustic measures of the patient's

Clinical impressions are substantially related to acoustic parameters.

Journal of affective disorders • 2001-09-15 • Randomized Controlled Trial
N = 19 88/100 PMID 11532533 ↗
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