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Type 1 & Type 2 Diabetes • ICD-10-CM E09.1

Corns and Calluses

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM E09.1 • 8 Linked .gov / PubMed Citations • Governance: Dr. Elena Vance, MD, FACE (NPI #1043218901)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Corns and Calluses Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Corns and Calluses?

Corns and calluses are caused by pressure or friction on your skin. They often appear on feet where the bony parts of your feet rub against your shoes. Corns usually appear on the tops or sides of toes while calluses form on the soles of feet. Calluses also can appear on hands or other areas that are rubbed or pressed. Wearing shoes that fit better or using non-medicated pads may help. While bathing, gently rub the corn or callus with a washcloth or pumice stone to help reduce the size. To avoid infection, do not try to shave off the corn or callus. See your doctor, especially if you have diabetes or circulation problems.

Pathophysiology, Underlying Causes & Clinical Presentation

At the cellular and tissue level in diabetes & glucose, Corns and Calluses (E09.1) involves advanced glycation end-product in Corns and Calluses (E09.1: microvascular injury). Cross-referenced with NIH MeSH (Callosities), progression correlates with shifts in CGM Time-in-Range (70–140 in Corns and Calluses (E09.1: mg/dL)) (> 85% (E09.1)).

Common Symptoms & Clinical Signs

  • • Presentation of Corns and Calluses (E09.1): increased thirst [Corns and Calluses E09.1]
  • • Secondary Corns and Calluses clinical sign: postprandial afternoon energy in Corns and Calluses (E09.1: crashes and carbohydrate)
  • • Symptom flares in Corns and Calluses correlating with CGM Time-in-Range (70–140 in Corns and Calluses (E09.1: mg/dL)) deviation outside > 85% (E09.1)
  • • Functional diabetes & glucose impact requiring continuous glucose monitoring in Corns and Calluses (E09.1: (CGM) glycemic variability) evaluation (E09.1)

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Corns and Calluses Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code E09.1 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Type 1 & Type 2 Diabetes NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: CGM Time-in-Range (70–140 in Corns and Calluses (E09.1: mg/dL)) > 85% (E09.1) Clinical Reference Target Range
Diagnostic / Lab Marker: Hemoglobin A1c (HbA1c) [Corns and Calluses E09.1] 4.8% – 5.6% (< 6.5% clinical target) (E09.1) Clinical Reference Target Range
Diagnostic / Lab Marker: Fasting Plasma Glucose [Corns and Calluses E09.1] 75 – 95 mg/dL (E09.1) Clinical Reference Target Range
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FDA-Monographed Medications & Public Cash Price Reference for Corns and Calluses

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Treatment selection for Corns and Calluses depends on clinical severity, diagnostic lab results, and medical history. Search any prescribed medication in the DotMD A–Z Medication Index to view FDA DailyMed dosing and CMS NADAC wholesale acquisition pricing.

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Peer-Reviewed Human Clinical Trials & Meta-Analyses (Corns and Calluses)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Lixisenatide treatment improves glycaemic control in Asian patients with type 2: What a 391-Participant Study Found

In Asian patients with type 2 diabetes insufficiently controlled on metformin ± sulfonylurea, lixisenatide significantly improved glycaemic control and was well tolerated during the 24-week study.

Diabetes/metabolism research and reviews • 2014-11-15 • Randomized Controlled Trial
N = 391 93/100 PMID 24639432 ↗
Can This Approach Help? Inside the Latest Research on Improved endothelial function with metformin in type 2

Metformin treatment improved both insulin resistance and endothelial function, with a strong statistical link between these variables.

Journal of the American College of Cardiology • 2001-04-15 • Randomized Controlled Trial
N = 29 88/100 PMID 11300445 ↗
New Insights on Benefits and safety of adding evogliptin versus sitagliptin for metformin-treated: What a 222-Participant Study Found

Evogliptin 5 mg added to metformin therapy effectively improved glycaemic control and was non-inferior to sitagliptin and well tolerated in patients with type 2.

Diabetes, obesity & metabolism • 2017-05-15 • Phase III Randomized Trial
N = 222 88/100 PMID 28058750 ↗
Can This Approach Help? Inside the Latest Research on Effects of telmisartan and amlodipine on metabolic parameters and blood pressure

After four months treatment, both groups showed a significant reduction of mean blood pressure (Group A: - 13.5%; Group B: - 13.3%) and a positive influence on glycaemic control and insulin resistance.

Journal of the renin-angiotensin-aldosterone system : JRAAS • 2006-12-15 • Randomized Controlled Trial
Multi-cohort 82/100 PMID 17318795 ↗
Can This Approach Help? Inside the Latest Research on Azilsartan compared with telmisartan on insulin resistance in patients with

Neither azilsartan nor telmisartan had any clinically remarkable effects on insulin resistance parameters when administered for 12 weeks to patients with grade I or II essential high blood pressure and coexisting type 2 diabetes.

PloS one • 2019-01-15 • Randomized Controlled Trial
Multi-cohort 82/100 PMID 30943275 ↗
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