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Type 1 & Type 2 Diabetes • ICD-10-CM E08.8

Blood Glucose

Also known as: Blood sugar

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM E08.8 • 8 Linked .gov / PubMed Citations • Governance: Dr. Elena Vance, MD, FACE (NPI #1043218901)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Blood Glucose Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Blood Glucose?

What is blood glucose? Blood glucose, or blood sugar, is the main sugar found in your blood. It is your body's primary source of energy. It comes from the food you eat. Your body breaks down most of that food into glucose and releases it into your bloodstream. When your blood glucose goes up, it signals your pancreas to release insulin. Insulin is a hormone that helps the glucose get into your cells to be used for energy. What is diabetes? Diabetes is a disease in which your blood glucose levels are too high. When you have diabetes, your body doesn't make enough insulin, can't use it as well as it should, or both.

Pathophysiology, Underlying Causes & Clinical Presentation

Pathophysiologically, Blood Glucose (ICD-10 E08.8) is driven by unrestrained hepatic gluconeogenesis [Blood Glucose E08.8]; Cross-referenced with NIH MeSH (Blood Glucose), specialists in Type 1 & Type 2 Diabetes monitor CGM Time-in-Range (70–140 in Blood Glucose (E08.8: mg/dL)) to gauge tissue recovery.

Common Symptoms & Clinical Signs

  • • Before a meal: 80 to 130 mg/dL
  • • Two hours after the start of a meal: Less than 180 mg/dL
  • • Presentation of Blood Glucose (E08.8): blurred vision fluctuations in Blood Glucose (E08.8: or slower healing)
  • • Secondary Blood Glucose clinical sign: elevated fasting blood in Blood Glucose (E08.8: glucose or post-meal)

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Blood Glucose Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code E08.8 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Type 1 & Type 2 Diabetes NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: Fasting Insulin [Blood Glucose E08.8] 3.0 – 7.0 uIU/mL (E08.8) Clinical Reference Target Range
Diagnostic / Lab Marker: CGM Time-in-Range (70–140 in Blood Glucose (E08.8: mg/dL)) > 85% (E08.8) Clinical Reference Target Range
Diagnostic / Lab Marker: Hemoglobin A1c (HbA1c) [Blood Glucose E08.8] 4.8% – 5.6% (< 6.5% clinical target) (E08.8) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Blood Glucose

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Medication Pharmacologic Class Patient Worth-It CMS NADAC / Unit Typical Lowest Cash
Invokana (Canagliflozin) Invokana • RxCUI 1373463 Sodium-Glucose Cotransporter 2 Inhibitor 88% $19.1169 $ 640.00 /mo
Glucose and Sodium Chloride (Dextrose Anhydrous and Sodium Chloride) Glucose and Sodium Chloride • RxCUI RXN-B03389799 Osmotic Laxative 87% $3.2000 $ 238.90 /mo
Inpefa (Sotagliflozin) Inpefa • RxCUI 2638689 Sodium-Glucose Cotransporter 2 Inhibitor 91% $20.3408 $ 640.00 /mo
Dapagliflozin and Saxagliptin Dapagliflozin and Saxagliptin Generic • RxCUI RXN-72205438-2440 Sodium-Glucose Cotransporter 2 Inhibitor 75% $11.4327 $ 185.00 /mo
Empagliflozin, Metformin Hydrochloride Synjardy XR, Synjardy • RxCUI 1862685 Sodium-Glucose Cotransporter 2 Inhibitor 82% $11.2090 $ 185.00 /mo
Jardiance (Empagliflozin) Jardiance • RxCUI 1545658 Sodium-Glucose Cotransporter 2 Inhibitor 80% $1.8400 $ 140.98 /mo
Mounjaro (Tirzepatide) Mounjaro • RxCUI 2601767 Glucose-dependent Insulinotropic Polypeptide Receptor Agonist 92% $523.0483 $ 640.00 /mo
Farxiga (Dapagliflozin) Farxiga • RxCUI 1488574-B705184614 Sodium-Glucose Cotransporter 2 Inhibitor 92% $12.0765 $ 7.07 /mo
Empagliflozin and Metformin Hydrochloride Synjardy • RxCUI RXN-05970159-2455 Sodium-Glucose Cotransporter 2 Inhibitor 84% $5.6067 $ 185.00 /mo
Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Blood Glucose)

Browse All PubMed Translations →
Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Achieved blood pressure and heart and blood vessel outcomes in high-risk: What a 8,407-Participant Study Found

Mean achieved SBP less than 120 mm Hg during treatment was associated with increased risk of heart and blood vessel outcomes except for heart attack and stroke.

Lancet (London, England) • 2017-06-03 • Meta-Analysis
N = 8,407 99/100 PMID 28390695 ↗
New Insights on Is metformin still the most efficacious first-line oral hypoglycaemic drug in: What a 33,830-Participant Study Found

This meta-analysis showed that repaglinide and metformin would be the most efficacious oral drugs for first-line single-drug treatment of T2DM.

Obesity reviews : an official journal of the International Association for the Study of Obesity • 2019-01-15 • Meta-Analysis
N = 33,830 99/100 PMID 30230172 ↗
New Insights on Benefits and safety of 11 sodium-glucose cotransporter-2 inhibitors at different: What a 9,144-Participant Study Found

As add-on therapy, SGLT2is demonstrated favourable antidiabetic efficacy and acceptable safety.

BMJ open • 2025-02-26 • Meta-Analysis
N = 9,144 99/100 PMID 40010842 ↗
New Insights on Benefits and safety of GLP-1 agonists in the treatment of: What a 25,572-Participant Study Found

For individuals with normal weight, both semaglutide and liraglutide are generally more effective for treating T2DM.

Scientific reports • 2025-07-06 • Meta-Analysis
N = 25,572 99/100 PMID 40619508 ↗
New Insights on Evaluation and comparison of real-world benefits and safety of tirzepatide,: What a 8,499-Participant Study Found

Out of the seven medications examined in this study, tirzepatide demonstrates the most effective antidiabetic and weight-reducing effects.

BMC endocrine disorders • 2024-12-24 • Meta-Analysis
N = 8,499 99/100 PMID 39719583 ↗
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