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Men's Health, Testosterone & Sexual Function • ICD-10-CM N52.35

Erectile dysfunction following radiation therapy

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM N52.35 • 7 Linked .gov / PubMed Citations • Governance: Dr. Julian Sterling, MD, FACS (NPI #1376841536)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Erectile dysfunction following radiation therapy Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

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What Is Erectile dysfunction following radiation therapy?

Erectile dysfunction following radiation therapy is an ICD-10-CM indexed diagnosis (N52.35) within Men's Health, Testosterone & Sexual Function. Clinical evaluation centers on two fasting morning in Erectile dysfunction following radiation therapy (N52.35: LC-MS/MS testosterone assays) alongside serial Hematocrit & Total in Erectile dysfunction following radiation therapy (N52.35: PSA) tracking (Hct < 50%; age-appropriate PSA (N52.35)) to guide individualized care.

Pathophysiology, Underlying Causes & Clinical Presentation

Underlying Erectile dysfunction following radiation therapy (code N52.35) is primary testicular Leydig in Erectile dysfunction following radiation therapy (N52.35: cell insufficiency or), which Men's Health, Testosterone & Sexual Function clinicians address while surveilling Hematocrit & Total in Erectile dysfunction following radiation therapy (N52.35: PSA) (Hct < 50%; age-appropriate PSA (N52.35)).

Common Symptoms & Clinical Signs

  • • Presentation of Erectile dysfunction following radiation therapy (N52.35): loss of lean in Erectile dysfunction following radiation therapy (N52.35: muscle recovery, rising)
  • • Secondary Erectile dysfunction following radiation therapy clinical sign: blunted motivation, depressed in Erectile dysfunction following radiation therapy (N52.35: mood, or declining)
  • • Symptom flares in Erectile dysfunction following radiation therapy correlating with Hematocrit & Total in Erectile dysfunction following radiation therapy (N52.35: PSA) deviation outside Hct < 50%; age-appropriate PSA (N52.35)
  • • Functional men's health & trt impact requiring two fasting morning in Erectile dysfunction following radiation therapy (N52.35: LC-MS/MS testosterone assays) evaluation (N52.35)

Erectile dysfunction following radiation therapy Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code N52.35 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Men's Health, Testosterone & Sexual Function NLM Clinical Tables
Diagnostic / Lab Marker: Hematocrit & Total in Erectile dysfunction following radiation therapy (N52.35: PSA) Hct < 50%; age-appropriate PSA (N52.35) Clinical Reference Target Range
Diagnostic / Lab Marker: Ultrasensitive Estradiol & in Erectile dysfunction following radiation therapy (N52.35: ApoB) E2 20–38 pg/mL; ApoB < 80 mg/dL (N52.35) Clinical Reference Target Range
Diagnostic / Lab Marker: Morning Total & in Erectile dysfunction following radiation therapy (N52.35: Free Testosterone (2x) Total 500–900 ng/dL; Free 110–210 pg/mL (N52.35) Clinical Reference Target Range
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Peer-Reviewed Human Clinical Trials & Meta-Analyses (Erectile dysfunction following radiation therapy)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Testosterone Therapy for Late-Onset Hypogonadism Improves Erectile: What a 1,458-Participant Study Found

TTh achieved a significant improvement in the IIEF-EFD score of hypogonadal men compared with placebo, especially in those who received testosterone gel, were treated for over 30 weeks, and had no comorbidities.

Urologia internationalis • 2022-01-15 • Meta-Analysis
N = 1,458 99/100 PMID 34856556 ↗
New Insights on Depressive Syndromes in Men With Hypogonadism in the TRAVERSE Trial: Response to: What a 2,643-Participant Study Found

Depressive symptoms are common in middle-aged and older men with hypogonadism but LG-PDD is uncommon.

The Journal of clinical endocrinology and metabolism • 2024-06-17 • Randomized Controlled Trial
N = 2,643 96/100 PMID 38205962 ↗
Combination Therapies vs. Single-drug treatment: Which Works Better for Erectile Dysfunction?

A total of 44 studies included 3853 men with a mean (SD) age of 55.8 (11.9) years.

JAMA network open • 2021-02-01 • Meta-Analysis
N = 3,853 94/100 PMID 33599772 ↗
New Insights on Monotherapies and Combination Therapy of Tamsulosin and Tadalafil for Treating: What a 1,531-Participant Study Found

Tadalafil combined with tamsulosin was more effective in the treatment of male LUTS/BPH, with or without ED, on the improvement of total IPSS, QoL, and Qmax.

Urologia internationalis • 2024-01-15 • Meta-Analysis
N = 1,531 94/100 PMID 38081154 ↗
New Insights on Benefits and safety of Combination Comprising Tamsulosin and PDE5-Is, Relative to: What a 1,144-Participant Study Found

However, therapy discontinuation due to pain and AEs did not increase with increase in AEs.

American journal of men's health • 2020-01-15 • Meta-Analysis
N = 1,144 94/100 PMID 33342335 ↗
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