PCOS, Endometriosis & Gynecologic Health • ICD-10-CM E28.0
Estrogens - elevated
Also known as: Hypertension, High blood pressure, Elevated, Secondary
Audited by the DotMD AI Specialist Council
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FDA DailyMed SPL: 2026-11-02 • ICD-10-CM E28.0 • 7 Linked .gov / PubMed Citations
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Governance: Dr. Elena Vance, MD, FACE (NPI #1043218901)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary
Estrogens - elevated Key Takeaways
Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level
- 1 What it does: Physicians managing Estrogens - elevated (also termed Hypertension or High blood pressure) (E28.0; PCOS, Endometriosis & Gynecologic Health) utilize minimally invasive gynecologic in Estrogens - elevated (E28.0: care) and objective CBC & Serum in Estrogens - elevated (E28.0: Ferritin (heavy bleeding)) targets (Ferritin > 50 ng/mL (E28.0)) to prevent progression and functional morbidity.
- 2 Real-world patient consensus: Mapped to PCOS, Endometriosis & Gynecologic Health under ICD-10-CM E28.0 for Estrogens - elevated clinical workups.
- 3 Typical cash cost range: Workup highlights for Estrogens - elevated (E28.0): minimally invasive gynecologic in Estrogens - elevated (E28.0: care).
- 4 Top reported side effects / signs: Objective lab/clinical target for Estrogens - elevated: CBC & Serum in Estrogens - elevated (E28.0: Ferritin (heavy bleeding)) (Ferritin > 50 ng/mL (E28.0)) and LH, FSH & in Estrogens - elevated (E28.0: Prolactin).
Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data
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What Is Estrogens - elevated?
Physicians managing Estrogens - elevated (also termed Hypertension or High blood pressure) (E28.0; PCOS, Endometriosis & Gynecologic Health) utilize minimally invasive gynecologic in Estrogens - elevated (E28.0: care) and objective CBC & Serum in Estrogens - elevated (E28.0: Ferritin (heavy bleeding)) targets (Ferritin > 50 ng/mL (E28.0)) to prevent progression and functional morbidity.
Pathophysiology, Underlying Causes & Clinical Presentation
At the cellular and tissue level in ob/gyn & pcos, Estrogens - elevated (E28.0) involves reduced hepatic SHBG in Estrogens - elevated (E28.0: (in PCOS)). progression correlates with shifts in CBC & Serum in Estrogens - elevated (E28.0: Ferritin (heavy bleeding)) (Ferritin > 50 ng/mL (E28.0)).
Common Symptoms & Clinical Signs
- • Presentation of Estrogens - elevated (E28.0): hyperandrogenic acne along in Estrogens - elevated (E28.0: the jawline, hirsutism,)
- • Secondary Estrogens - elevated clinical sign: pelvic pressure, bloating, in Estrogens - elevated (E28.0: or pain radiating)
- • Symptom flares in Estrogens - elevated correlating with CBC & Serum in Estrogens - elevated (E28.0: Ferritin (heavy bleeding)) deviation outside Ferritin > 50 ng/mL (E28.0)
- • Functional ob/gyn & pcos impact requiring minimally invasive gynecologic in Estrogens - elevated (E28.0: care) evaluation (E28.0)
Estrogens - elevated Diagnostic Classification & Lab Markers
| Metric | Verified Benchmark | Source |
|---|---|---|
| ICD-10-CM Diagnostic Code | E28.0 | WHO / CMS ICD-10-CM Clinical Classification |
| Clinical Specialty Hub | PCOS, Endometriosis & Gynecologic Health | NLM Clinical Tables |
| Diagnostic / Lab Marker: CBC & Serum in Estrogens - elevated (E28.0: Ferritin (heavy bleeding)) | Ferritin > 50 ng/mL (E28.0) | Clinical Reference Target Range |
| Diagnostic / Lab Marker: LH, FSH & in Estrogens - elevated (E28.0: Prolactin) | Normal ovulatory endocrine axis (E28.0) | Clinical Reference Target Range |
| Diagnostic / Lab Marker: Free & Total in Estrogens - elevated (E28.0: Testosterone + SHBG) | Sex-specific physiological range (E28.0) | Clinical Reference Target Range |
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance
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FDA-Monographed Medications & Public Cash Price Reference for Estrogens - elevated
| Medication | Pharmacologic Class | Patient Worth-It | CMS NADAC / Unit | Typical Lowest Cash |
|---|---|---|---|---|
| Colesevelam Hydrochloride Welchol • RxCUI 866910 | Bile Acid Sequestrant | 89% | $0.2608 | $ 8.66 /mo |
| Latanoprost Ophthalmic Solution 0.005% Iyuzeh • RxCUI 314072 | Prostaglandin Analog | 75% | $10.1187 | $ 185.00 /mo |
| Timolol Betimol, Timoptic • RxCUI 208560 | beta-Adrenergic Blocker | 74% | $31.0625 | $ 6.97 /mo |
| Brimonidine Tartrate/Timolol Maleate (Brimonidine Tartrate and Timolol Maleate) Brimonidine Tartrate/Timolol Maleate • RxCUI RXN-B68462281 | alpha-Adrenergic Agonist | 94% | $1.9993 | $ 152.45 /mo |
| Cholestyramine Prevalite, Questran • RxCUI 848943 | Bile Acid Sequestrant | 93% | $0.1507 | $ 25.70 /mo |
| Brinzolamide Azopt • RxCUI 213272 | Carbonic Anhydrase Inhibitor | 93% | $35.0627 | $ 62.50 /mo |
| Estratest F.s. (Esterified Estrogens, Methyltestosterone) Estratest F.s. • RxCUI RXN-B58657404 | Androgen | 77% | $1.1300 | $ 89.86 /mo |
| Travoprost Travatan Z • RxCUI 284008 | Prostaglandin Analog | 93% | $94.1791 | $ 15.22 /mo |
| Brimonidine Tartrate Alphagan P, Lumify Preservative Free Eye Drops • RxCUI 861204 | alpha-Adrenergic Agonist | 92% | $8.1556 | $ 9.60 /mo |
| Brimonidine Tartrate and Timolol Maleate Brimonidine Tartrate/Timolol Maleate Ophthalmic Solution, Brimonidine Tartrate/Timolol Maleate • RxCUI 861635 | alpha-Adrenergic Agonist | 92% | $1.8390 | $ 82.98 /mo |
| Echothiophate Iodide for Ophthalmic Solution Phospholine Iodide • RxCUI 205739 | FDA Prescription Therapeutic Agent | 79% | $1.8900 | $ 85.05 /mo |
| Timolol Maleate Timoptic, Timolol Gfs • RxCUI 1923428 | beta-Adrenergic Blocker | 82% | $1.0344 | $ 6.97 /mo |
| Lumigan (Bimatoprost) Lumigan • RxCUI 1009339 | Prostaglandin Analog | 80% | $101.0567 | $ 15.06 /mo |
| Esterified Estrogens, Methyltestosterone Esterified Estrogens and Methyltestosterone, Estratest F.s. • RxCUI 238006 | Androgen | 80% | $1.1800 | $ 56.29 /mo |
| Dorzolamide Hydrochloride Timolol Maleate Cosopt • RxCUI 1923432 | Carbonic Anhydrase Inhibitor | 93% | $0.8853 | $ 10.75 /mo |
| Latisse (Bimatoprost) Latisse • RxCUI 1041495-B00233616 | Prostaglandin Analog | 80% | $31.4314 | $ 77.45 /mo |
Dr. Lin (AI PubMed Clinical Trial Lead)
Browse All PubMed Translations →
Peer-Reviewed Human Clinical Trials & Meta-Analyses (Estrogens - elevated)
| Study & Plain-English Finding | Sample (N) | Rigor | Primary Source |
|---|---|---|---|
| New Insights on Longitudinal changes in menopausal symptoms comparing women randomized to: What a 727-Participant Study Found Recently postmenopausal women had similar and substantial reductions in hot flashes and night sweats with lower-than-conventional doses of oral or transdermal estrogen. Menopause (New York, N.Y.) • 2017-03-15 • Randomized Controlled Trial | N = 727 | 93/100 | PMID 27779568 ↗ |
| Can This Approach Help? Inside the Latest Research on Effect of orally administered oestrogens on gonadotrophin levels in Treatment with all oestrogen formulations decreased, and the addition of levonorgestrel increased the ratio of bioactive (B) to immunoreactive (I) LH. Maturitas • 1989-06-15 • Randomized Controlled Trial | Multi-cohort | 88/100 | PMID 2547138 ↗ |
| Can This Approach Help? Inside the Latest Research on Effects of 17 beta-oestradiol plus dydrogesterone compared with conjugated equine E/D and CEE/MPA differ in their anti-atherogenic effects on lipids and lipoproteins. Maturitas • 2004-11-15 • Randomized Controlled Trial | N = 180 | 88/100 | PMID 15488354 ↗ |
| Can This Approach Help? Inside the Latest Research on Alcohol ingestion on estrogens in postmenopausal Acute alcohol ingestion may lead to significant and sustained elevations in circulating estradiol to levels 300% higher than those targeted in clinical use of ERT. JAMA • 1996-12-04 • Randomized Controlled Trial | Multi-cohort | 88/100 | PMID 8940324 ↗ |
| Can This Approach Help? Inside the Latest Research on Aromatized Estrogens Amplify Nocturnal Growth Hormone Secretion in E2 administration in older men transdermally stimulates overnight pulsatile GH secretion. The Journal of clinical endocrinology and metabolism • 2018-12-01 • Randomized Controlled Trial | N = 74 | 88/100 | PMID 30032193 ↗ |
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