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Osteoarthritis, Gout & Joint Pain • ICD-10-CM M19.6

Infectious Arthritis

Also known as: Septic arthritis

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM M19.6 • 8 Linked .gov / PubMed Citations • Governance: Dr. Hannah Lindqvist, MD, PhD (NPI #1457952647)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Infectious Arthritis Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Infectious Arthritis?

Most kinds of arthritis cause pain and swelling in your joints. Joints are places where two bones meet, such as your elbow or knee. Infectious arthritis is an infection in the joint. The infection comes from a bacterial, viral, or fungal infection that spreads from another part of the body. Symptoms of infectious arthritis include: Intense pain in the joint Joint redness and swelling Chills and fever Inability to move the area with the infected joint One type of infectious arthritis is reactive arthritis. The reaction is to an infection somewhere else in your body. The joint is usually the knee, ankle, or toe.

Pathophysiology, Underlying Causes & Clinical Presentation

Pathophysiologically, Infectious Arthritis (ICD-10 M19.6) is driven by articular hyaline cartilage in Infectious Arthritis (M19.6: proteoglycan degradation); Cross-referenced with NIH MeSH (Arthritis, Infectious), specialists in Osteoarthritis, Gout & Joint Pain monitor hs-CRP & Erythrocyte in Infectious Arthritis (M19.6: Sedimentation Rate) to gauge tissue recovery.

Common Symptoms & Clinical Signs

  • • Intense pain in the joint
  • • Joint redness and swelling
  • • Presentation of Infectious Arthritis (M19.6): sudden, intensely painful, in Infectious Arthritis (M19.6: red swollen big-toe)
  • • Secondary Infectious Arthritis clinical sign: localized tendon or in Infectious Arthritis (M19.6: bursa tenderness limiting)

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Infectious Arthritis Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code M19.6 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Osteoarthritis, Gout & Joint Pain NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: Serum Uric Acid in Infectious Arthritis (M19.6: (Gout Target)) < 6.0 mg/dL (< 5.0 mg/dL with tophi) (M19.6) Clinical Reference Target Range
Diagnostic / Lab Marker: hs-CRP & Erythrocyte in Infectious Arthritis (M19.6: Sedimentation Rate) hs-CRP < 1.5 mg/L; ESR < 15 mm/hr (M19.6) Clinical Reference Target Range
Diagnostic / Lab Marker: Weight-Bearing Joint Radiograph [Infectious Arthritis M19.6] Preserved joint-space width (M19.6) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Infectious Arthritis

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Medication Pharmacologic Class Patient Worth-It CMS NADAC / Unit Typical Lowest Cash
Universal Arthritis and Sport (Methyl Salicylate, Capsicum) Universal Arthritis and Sport • RxCUI 2671957-B52000302 Non-Standardized Plant Allergenic Extract 91% $1.2600 $ 99.22 /mo
Lidocaine 4.5%, Diclofenac 1% Diclona • RxCUI 2600049 Amide Local Anesthetic 82% $0.0989 $ 12.50 /mo
Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Infectious Arthritis)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
Managing Psoriatic arthritis: Can Upadacitinib on enthesitis Make a Real Difference? (What a 639-Person Study Found)

UPA15 is associated with a comprehensive improvement in enthesitis, with improvements observed after 12 weeks of treatment.

Rheumatology (Oxford, England) • 2024-11-01 • Phase III Randomized Trial
N = 639 93/100 PMID 38331400 ↗
New Insights on Effectiveness of Intrarectal Povidone-iodine Cleansing Plus Formalin Disinfection: What a 633-Participant Study Found

Intrarectal povidone-iodine cleansing plus formalin disinfection of the biopsy needle tip was associated with a reduction in infectious complications after transrectal prostate biopsy.

The Journal of urology • 2022-12-15 • Phase III Randomized Trial
N = 633 87/100 PMID 36006040 ↗
New Insights on Prognostic Impact of Post-operative Infectious Complications in Gastric Cancer: What a 224-Participant Study Found

This study could not indicate the negative prognostic influence of ICs in gastric cancer patients receiving NAC, which might be canceled by NAC.

Journal of gastrointestinal cancer • 2024-09-15 • Phase III Randomized Trial
N = 224 82/100 PMID 38703333 ↗
Can This Approach Help? Inside the Latest Research on Extension study of the safety and real-world benefits of CLS-TA for treatment of

Approximately 50% of patients did not require additional treatment for up to 9 months following the last CLS-TA administration.

The British journal of ophthalmology • 2022-08-15 • Phase III Randomized Trial
N = 33 82/100 PMID 33712478 ↗
Can This Approach Help? Inside the Latest Research on Early clinical response associates with long-term outcomes with ixekizumab in

This analysis reinforces the current recommendation that continuing treatment in those achieving ASDAS CII at week 12 and/or week 24 increases the likelihood of obtaining ID/LDA at week 52.

RMD open • 2024-07-14 • Phase III Randomized Trial
N = 33 82/100 PMID 39004432 ↗
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Infectious Arthritis Patient Community & “People Like Me” Threads

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