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Cancer, Oncology & Supportive Care • ICD-10-CM C64.9

Kidney Cancer

Also known as: Hypernephroma, Renal cancer, Kidney, Renal, Nephric

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM C64.9 • 8 Linked .gov / PubMed Citations • Governance: Dr. Julian Sterling, MD, FACS (NPI #1376841536)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Kidney Cancer Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Kidney Cancer?

You have two kidneys. They are fist-sized organs on either side of your backbone above your waist. The tubes inside filter and clean your blood, taking out waste products and making urine. Kidney cancer forms in the lining of tiny tubes inside your kidneys. Kidney cancer becomes more likely as you age. Risk factors include smoking, having certain genetic conditions, and misusing pain medicines for a long time. You may have no symptoms at first. They may appear as the cancer grows.

Pathophysiology, Underlying Causes & Clinical Presentation

Tissue-level etiology in Kidney Cancer (C64.9) features local tissue remodeling [Kidney Cancer C64.9]. Cross-referenced with NIH MeSH (Kidney Neoplasms), therapeutic stabilization in cancer & oncology is verified against Comprehensive Metabolic & in Kidney Cancer (C64.9: Organ Function Panel).

Common Symptoms & Clinical Signs

  • • Blood in your urine
  • • A lump in your abdomen
  • • Presentation of Kidney Cancer (C64.9): unexplained bleeding, chronic in Kidney Cancer (C64.9: hoarseness/cough, or progressive)
  • • Secondary Kidney Cancer clinical sign: abnormality detected early in Kidney Cancer (C64.9: on age-appropriate screening)

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Kidney Cancer Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code C64.9 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Cancer, Oncology & Supportive Care NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: Complete Blood Count in Kidney Cancer (C64.9: (ANC, Hemoglobin, Platelets)) Safe hematologic reserve (C64.9) Clinical Reference Target Range
Diagnostic / Lab Marker: Comprehensive Metabolic & in Kidney Cancer (C64.9: Organ Function Panel) Preserved renal/hepatic clearance (C64.9) Clinical Reference Target Range
Diagnostic / Lab Marker: Pathology / Molecular in Kidney Cancer (C64.9: Genomic Staging) Guideline-concordant surveillance (C64.9) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Kidney Cancer

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Treatment selection for Kidney Cancer depends on clinical severity, diagnostic lab results, and medical history. Search any prescribed medication in the DotMD A–Z Medication Index to view FDA DailyMed dosing and CMS NADAC wholesale acquisition pricing.

Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Kidney Cancer)

Browse All PubMed Translations →
Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Safety and real-world benefits of Semaglutide in Patients With Chronic Kidney: What a 12,785-Participant Study Found

Semaglutide demonstrates a favourable safety profile and significant cardiorenal benefits in CKD patients, with or without T2DM.

Endocrinology, diabetes & metabolism • 2025-11-15 • Meta-Analysis
N = 12,785 99/100 PMID 41276951 ↗
New Insights on Heart and blood vessel and Kidney Outcomes and Mortality With Long-Acting: What a 71,351-Participant Study Found

As a group, long-acting GLP-1RA, including both injectable and oral formulations, reduce incidence of MACE, HHF, and kidney events and all-cause mortality in T2D.

Diabetes care • 2025-05-01 • Meta-Analysis
N = 71,351 99/100 PMID 40156846 ↗
Can This Approach Help? Inside the Latest Research on Intermittent or Continuous kidney-Replacement Therapy in Acute Kidney

New England Journal of Medicine, Volume 395, Issue 17 , Page 1677-1690, October 29, 2026.

New England Journal of Medicine • 2026-10-14 • Peer-Reviewed Journal (Clinical Trials)
Multi-cohort 97/100 PMID NEJM-62256824 ↗
New Insights on Individual Atrasentan Exposure is Associated With Long-term Kidney and Heart: What a 3,668-Participant Study Found

Compared with placebo, a mean atrasentan exposure translated in a hazard ratio of 0.76 (95% confidence interval (CI): 0.28-0.85) for kidney events and 1.13 (95% CI: 1.03-2.20) for heart failure events.

Clinical pharmacology and therapeutics • 2021-06-15 • Phase III Randomized Trial
N = 3,668 96/100 PMID 33338269 ↗
New Insights on Empagliflozin Reduces Risk of Hospitalization in Patients With Chronic Kidney: What a 6,609-Participant Study Found

1995 participants (1035 placebo, 960 empagliflozin) had ≥1 ACH (1895 ACH in placebo and 1611 in the empagliflozin 10-mg groups).

Clinical therapeutics • 2025-12-15 • Phase III Randomized Trial
N = 6,609 96/100 PMID 41047325 ↗
Zero-PHI Patient Support & Cohort Discussions

Kidney Cancer Patient Community & “People Like Me” Threads

“People Like Me” Cohort Filter (Zero-PHI)

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