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Cancer, Oncology & Supportive Care • ICD-10-CM D27.9

Leydig cell tumor - benign

Also known as: Fibroid, Leiomyoma, Fibrous, Tumor

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM D27.9 • 8 Linked .gov / PubMed Citations • Governance: Dr. Devon Caldwell, DO, MPH (NPI #1568063758)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Leydig cell tumor - benign Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Leydig cell tumor - benign?

Under Cancer, Oncology & Supportive Care diagnostic criteria (D27.9), workup for Leydig cell tumor - benign (also termed Fibroid or Leiomyoma) integrates immunohistochemistry [Leydig cell tumor - benign D27.9] with evidence-graded therapy tailored to Pathology / Molecular in Leydig cell tumor - benign (D27.9: Genomic Staging) response.

Pathophysiology, Underlying Causes & Clinical Presentation

Mechanistic hallmarks of Leydig cell tumor - benign (D27.9) center on angiogenesis [Leydig cell tumor - benign D27.9]. targeted cancer & oncology interventions aim to normalize Pathology / Molecular in Leydig cell tumor - benign (D27.9: Genomic Staging).

Common Symptoms & Clinical Signs

  • • Presentation of Leydig cell tumor - benign (D27.9): abnormality detected early in Leydig cell tumor - benign (D27.9: on age-appropriate screening)
  • • Secondary Leydig cell tumor - benign clinical sign: persistent painless lump, in Leydig cell tumor - benign (D27.9: non-healing ulcer/mole change,)
  • • Symptom flares in Leydig cell tumor - benign correlating with Pathology / Molecular in Leydig cell tumor - benign (D27.9: Genomic Staging) deviation outside Guideline-concordant surveillance (D27.9)
  • • Functional cancer & oncology impact requiring immunohistochemistry [Leydig cell tumor - benign D27.9] evaluation (D27.9)

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Leydig cell tumor - benign Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code D27.9 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Cancer, Oncology & Supportive Care NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: Pathology / Molecular in Leydig cell tumor - benign (D27.9: Genomic Staging) Guideline-concordant surveillance (D27.9) Clinical Reference Target Range
Diagnostic / Lab Marker: Complete Blood Count in Leydig cell tumor - benign (D27.9: (ANC, Hemoglobin, Platelets)) Safe hematologic reserve (D27.9) Clinical Reference Target Range
Diagnostic / Lab Marker: Comprehensive Metabolic & in Leydig cell tumor - benign (D27.9: Organ Function Panel) Preserved renal/hepatic clearance (D27.9) Clinical Reference Target Range
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FDA-Monographed Medications & Public Cash Price Reference for Leydig cell tumor - benign

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Treatment selection for Leydig cell tumor - benign depends on clinical severity, diagnostic lab results, and medical history. Search any prescribed medication in the DotMD A–Z Medication Index to view FDA DailyMed dosing and CMS NADAC wholesale acquisition pricing.

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Peer-Reviewed Human Clinical Trials & Meta-Analyses (Leydig cell tumor - benign)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
Can This Approach Help? Inside the Latest Research on Deutenzalutamide, a novel androgen receptor inhibitor, after progression on

In summary, deutenzalutamide significantly prolonged rPFS and, after adjustment, showed a potential OS benefit with a favorable safety profile, supporting its promise as a new treatment option for mCRPC.

Signal transduction and targeted therapy • 2026-04-13 • Phase III Randomized Trial
Multi-cohort 88/100 PMID 41968137 ↗
New Insights on Cost-effectiveness of prophylactic cranial irradiation in stage III non-small: What a 670-Participant Study Found

PCI is cost-effective compared to no PCI in stage III NSCLC, and could therefore, from a cost-effectiveness perspective, be considered in routine care.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology • 2022-05-15 • Phase III Randomized Trial
N = 670 87/100 PMID 35259416 ↗
Can This Approach Help? Inside the Latest Research on Interaction Between SNP Genotype and Efficacy of Anastrozole and Exemestane in

LY75 and GPR160 participate in epithelial-to-mesenchymal transition and growth pathways, in both cases with SNP-dependent variation in regulation.

Clinical pharmacology and therapeutics • 2021-10-15 • Phase III Randomized Trial
Multi-cohort 82/100 PMID 34048027 ↗
Can This Approach Help? Inside the Latest Research on A genetically defined signature of responsiveness to erlotinib in early-stage

This study identified five biologically distinct patient clusters with different actionable lesions and unravelled a previously unappreciated association of SMAD4 alteration status with erlotinib effectiveness.

EBioMedicine • 2021-04-15 • Phase III Randomized Trial
N = 91 82/100 PMID 33862582 ↗
Can This Approach Help? Inside the Latest Research on Alpelisib for the treatment of PIK3CA -mutated, hormone receptor-positive,

The PFS benefit appears clinically significant over fulvestrant alone, with a 7.9 months, non-significant, improvement in overall survival.

Expert opinion on pharmacotherapy • 2021-04-15 • Phase III Randomized Trial
Multi-cohort 82/100 PMID 33622114 ↗
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