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Depression, Bipolar & Mood Disorders • ICD-10-CM F33.41

Major depressive disorder, recurrent, in partial remission

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM F33.41 • 7 Linked .gov / PubMed Citations • Governance: Dr. Hannah Lindqvist, MD, PhD (NPI #1457952647)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Major depressive disorder, recurrent, in partial remission Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

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What Is Major depressive disorder, recurrent, in partial remission?

Recognized across U.S. clinical coding as F33.41 (Depression & Mood), Major depressive disorder, recurrent, in partial remission is evaluated via sleep-wake rhythm assessment [Major depressive disorder, recurrent, in partial remission F33.41] to align day-to-day symptom relief with long-term physiological stability.

Pathophysiology, Underlying Causes & Clinical Presentation

Pathophysiologically, Major depressive disorder, recurrent, in partial remission (ICD-10 F33.41) is driven by circadian phase instability [Major depressive disorder, recurrent, in partial remission F33.41]; specialists in Depression, Bipolar & Mood Disorders monitor TSH & Free in Major depressive disorder, recurrent, in partial remission (F33.41: T4 Rule-Out) to gauge tissue recovery.

Common Symptoms & Clinical Signs

  • • Presentation of Major depressive disorder, recurrent, in partial remission (F33.41): slowed concentration, indecisiveness, in Major depressive disorder, recurrent, in partial remission (F33.41: and physical heaviness)
  • • Secondary Major depressive disorder, recurrent, in partial remission clinical sign: loss of interest in Major depressive disorder, recurrent, in partial remission (F33.41: or pleasure in)
  • • Symptom flares in Major depressive disorder, recurrent, in partial remission correlating with PHQ-9 Symptom Severity in Major depressive disorder, recurrent, in partial remission (F33.41: Score) deviation outside < 4 (clinical remission) (F33.41)
  • • Functional depression & mood impact requiring sleep-wake rhythm assessment [Major depressive disorder, recurrent, in partial remission F33.41] evaluation (F33.41)

Major depressive disorder, recurrent, in partial remission Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code F33.41 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Depression, Bipolar & Mood Disorders NLM Clinical Tables
Diagnostic / Lab Marker: PHQ-9 Symptom Severity in Major depressive disorder, recurrent, in partial remission (F33.41: Score) < 4 (clinical remission) (F33.41) Clinical Reference Target Range
Diagnostic / Lab Marker: TSH & Free in Major depressive disorder, recurrent, in partial remission (F33.41: T4 Rule-Out) TSH 0.8 – 2.5 mIU/L (F33.41) Clinical Reference Target Range
Diagnostic / Lab Marker: Serum Vitamin D in Major depressive disorder, recurrent, in partial remission (F33.41: & RBC Folate) 25(OH)D 40 – 65 ng/mL (F33.41) Clinical Reference Target Range
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Peer-Reviewed Human Clinical Trials & Meta-Analyses (Major depressive disorder, recurrent, in partial remission)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Meta-Analysis: Dose-Response Relationship of Selective Serotonin Reuptake: What a 10,039-Participant Study Found

Higher doses of SSRIs appear slightly more effective in depression.

The American journal of psychiatry • 2016-02-01 • Meta-Analysis
N = 10,039 99/100 PMID 26552940 ↗
New Insights on Pharmacological and non-pharmacological treatments for depression in: What a 10,991-Participant Study Found

Herbal medicine and mirtazapine had no significant difference in overall risk of side effects compared with placebo.

Psychiatry research • 2019-11-15 • Meta-Analysis
N = 10,991 99/100 PMID 31627074 ↗
New Insights on Efficacy and tolerability of antidepressant drugs in treatment of depression in: What a 6,949-Participant Study Found

A total of 33 RCTs were included in 32 articles, involving 6949 patients.

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences • 2022-08-01 • Meta-Analysis
N = 6,949 99/100 PMID 37202104 ↗
New Insights on Antidepressants for the treatment of adults with depression in the maintenance: What a 9,384-Participant Study Found

Compared to placebo, venlafaxine was associated with a lower incidence of dizziness, while desvenlafaxine, sertraline, and vortioxetine were associated with a higher incidence of nausea/vomiting.

Molecular psychiatry • 2023-01-15 • Meta-Analysis
N = 9,384 99/100 PMID 36253442 ↗
New Insights on Modeling the efficacy of a novel antidepressant zuranolone for: What a 8,735-Participant Study Found

Primary side effects related to zuranolone included somnolence, headache, dizziness, and sedation, with no severe safety signals observed.

Journal of affective disorders • 2026-01-01 • Meta-Analysis
N = 8,735 99/100 PMID 40876640 ↗
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