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Depression, Bipolar & Mood Disorders • ICD-10-CM F30.2

Manic episode, severe with psychotic symptoms

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM F30.2 • 7 Linked .gov / PubMed Citations • Governance: Dr. Hannah Lindqvist, MD, PhD (NPI #1457952647)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Manic episode, severe with psychotic symptoms Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

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What Is Manic episode, severe with psychotic symptoms?

Within Depression, Bipolar & Mood Disorders practice, Manic episode, severe with psychotic symptoms (ICD-10 F30.2) is stratified through safety/support screening [Manic episode, severe with psychotic symptoms F30.2], pairing targeted symptom control with longitudinal Serum Vitamin D in Manic episode, severe with psychotic symptoms (F30.2: & RBC Folate) surveillance.

Pathophysiology, Underlying Causes & Clinical Presentation

Pathophysiologically, Manic episode, severe with psychotic symptoms (ICD-10 F30.2) is driven by monoaminergic (serotonin [Manic episode, severe with psychotic symptoms F30.2]; specialists in Depression, Bipolar & Mood Disorders monitor Serum Vitamin D in Manic episode, severe with psychotic symptoms (F30.2: & RBC Folate) to gauge tissue recovery.

Common Symptoms & Clinical Signs

  • • Presentation of Manic episode, severe with psychotic symptoms (F30.2): disrupted sleep architecture [Manic episode, severe with psychotic symptoms F30.2]
  • • Secondary Manic episode, severe with psychotic symptoms clinical sign: slowed concentration, indecisiveness, in Manic episode, severe with psychotic symptoms (F30.2: and physical heaviness)
  • • Symptom flares in Manic episode, severe with psychotic symptoms correlating with TSH & Free in Manic episode, severe with psychotic symptoms (F30.2: T4 Rule-Out) deviation outside TSH 0.8 – 2.5 mIU/L (F30.2)
  • • Functional depression & mood impact requiring safety/support screening [Manic episode, severe with psychotic symptoms F30.2] evaluation (F30.2)

Manic episode, severe with psychotic symptoms Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code F30.2 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Depression, Bipolar & Mood Disorders NLM Clinical Tables
Diagnostic / Lab Marker: TSH & Free in Manic episode, severe with psychotic symptoms (F30.2: T4 Rule-Out) TSH 0.8 – 2.5 mIU/L (F30.2) Clinical Reference Target Range
Diagnostic / Lab Marker: Serum Vitamin D in Manic episode, severe with psychotic symptoms (F30.2: & RBC Folate) 25(OH)D 40 – 65 ng/mL (F30.2) Clinical Reference Target Range
Diagnostic / Lab Marker: PHQ-9 Symptom Severity in Manic episode, severe with psychotic symptoms (F30.2: Score) < 4 (clinical remission) (F30.2) Clinical Reference Target Range
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Treatment selection for Manic episode, severe with psychotic symptoms depends on clinical severity, diagnostic lab results, and medical history. Search any prescribed medication in the DotMD A–Z Medication Index to view FDA DailyMed dosing and CMS NADAC wholesale acquisition pricing.

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Peer-Reviewed Human Clinical Trials & Meta-Analyses (Manic episode, severe with psychotic symptoms)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Pharmacological and non-pharmacological treatments for depression in: What a 10,991-Participant Study Found

Herbal medicine and mirtazapine had no significant difference in overall risk of side effects compared with placebo.

Psychiatry research • 2019-11-15 • Meta-Analysis
N = 10,991 99/100 PMID 31627074 ↗
New Insights on Benefits and safety of bupropion hydrochloride extended-release versus: What a 538-Participant Study Found

Results from this study demonstrated that the efficacy of bupropion XL was non-inferior to that of escitalopram in Chinese patients with MDD.

Journal of affective disorders • 2019-10-01 • Randomized Controlled Trial
N = 538 93/100 PMID 31301615 ↗
Can This Approach Help? Inside the Latest Research on Sexual function during bupropion or paroxetine treatment of

According to the Sex FX scale, a significant difference in antidepressant-related sexual dysfunction was detected in men, but not women, during treatment with bupropion SR or paroxetine.

Canadian journal of psychiatry. Revue canadienne de psychiatrie • 2006-03-15 • Randomized Controlled Trial
Multi-cohort 88/100 PMID 16629348 ↗
Can This Approach Help? Inside the Latest Research on Impact of missing data on clinical trials: a re-analysis of a placebo controlled

There is no difference between hypericum and placebo, regardless of the assumption about the missing data process.

Psychopharmacology • 2014-05-15 • Randomized Controlled Trial
Multi-cohort 88/100 PMID 24232445 ↗
Can This Approach Help? Inside the Latest Research on Effect of adjunctive cariprazine on symptoms of anhedonia in patients with

In patients with MDD and moderate-to-severe anhedonia, adjunctive cariprazine improved symptoms of general depression and anhedonia, suggesting a potential benefit for patients with this clinically significant symptom.

Journal of affective disorders • 2025-09-15 • Phase III Randomized Trial
Multi-cohort 88/100 PMID 40339720 ↗
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Manic episode, severe with psychotic symptoms Patient Community & “People Like Me” Threads

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