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Depression, Bipolar & Mood Disorders • ICD-10-CM F33.8

Other recurrent depressive disorders

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM F33.8 • 7 Linked .gov / PubMed Citations • Governance: Dr. Hannah Lindqvist, MD, PhD (NPI #1457952647)
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Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Other recurrent depressive disorders Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

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What Is Other recurrent depressive disorders?

Cataloged under federal diagnostic code F33.8 in Depression & Mood, Other recurrent depressive disorders requires medication response pharmacogenomics [Other recurrent depressive disorders F33.8] so specialists can calibrate treatment intensity against TSH & Free in Other recurrent depressive disorders (F33.8: T4 Rule-Out) benchmarks.

Pathophysiology, Underlying Causes & Clinical Presentation

Mechanistic hallmarks of Other recurrent depressive disorders (F33.8) center on hypothalamic-pituitary-adrenal (HPA) axis in Other recurrent depressive disorders (F33.8: cortisol hyperactivity). targeted depression & mood interventions aim to normalize TSH & Free in Other recurrent depressive disorders (F33.8: T4 Rule-Out).

Common Symptoms & Clinical Signs

  • • Presentation of Other recurrent depressive disorders (F33.8): slowed concentration, indecisiveness, in Other recurrent depressive disorders (F33.8: and physical heaviness)
  • • Secondary Other recurrent depressive disorders clinical sign: loss of interest in Other recurrent depressive disorders (F33.8: or pleasure in)
  • • Symptom flares in Other recurrent depressive disorders correlating with TSH & Free in Other recurrent depressive disorders (F33.8: T4 Rule-Out) deviation outside TSH 0.8 – 2.5 mIU/L (F33.8)
  • • Functional depression & mood impact requiring medication response pharmacogenomics [Other recurrent depressive disorders F33.8] evaluation (F33.8)

Other recurrent depressive disorders Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code F33.8 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Depression, Bipolar & Mood Disorders NLM Clinical Tables
Diagnostic / Lab Marker: TSH & Free in Other recurrent depressive disorders (F33.8: T4 Rule-Out) TSH 0.8 – 2.5 mIU/L (F33.8) Clinical Reference Target Range
Diagnostic / Lab Marker: Serum Vitamin D in Other recurrent depressive disorders (F33.8: & RBC Folate) 25(OH)D 40 – 65 ng/mL (F33.8) Clinical Reference Target Range
Diagnostic / Lab Marker: PHQ-9 Symptom Severity in Other recurrent depressive disorders (F33.8: Score) < 4 (clinical remission) (F33.8) Clinical Reference Target Range
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Treatment selection for Other recurrent depressive disorders depends on clinical severity, diagnostic lab results, and medical history. Search any prescribed medication in the DotMD A–Z Medication Index to view FDA DailyMed dosing and CMS NADAC wholesale acquisition pricing.

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Peer-Reviewed Human Clinical Trials & Meta-Analyses (Other recurrent depressive disorders)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Valsartan vs. other angiotensin II receptor blockers in the treatment of high: What a 13,110-Participant Study Found

Valsartan administered at 160 or 320 mg is more effective at lowering BP than losartan 100 mg and shows comparable efficacy to other ARBs in patients with essential high blood pressure.

International journal of clinical practice • 2009-05-15 • Meta-Analysis
N = 13,110 99/100 PMID 19392925 ↗
New Insights on Efficacy and tolerability of antidepressant drugs in treatment of depression in: What a 6,949-Participant Study Found

A total of 33 RCTs were included in 32 articles, involving 6949 patients.

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences • 2022-08-01 • Meta-Analysis
N = 6,949 99/100 PMID 37202104 ↗
New Insights on Efficacy comparison of monotherapies and combination therapies for androgenetic: What a 3,133-Participant Study Found

In recent years, combination therapies are showing significant promise as potential therapies.

Dermatologic therapy • 2022-03-15 • Meta-Analysis
N = 3,133 99/100 PMID 34897933 ↗
New Insights on Combination Therapy in Androgenetic hair loss: A Network Meta-Analysis of: What a 3,012-Participant Study Found

Based on the current studies, we found that the combination of Minoxidil with spironolactone, PRPF, flutamide, and finasteride may offer better treatment outcomes for patients with androgenetic hair loss.

Aesthetic plastic surgery • 2026-07-15 • Meta-Analysis
N = 3,012 99/100 PMID 42168420 ↗
New Insights on Safety profile of telmisartan as single-drug treatment or combined with: What a 8,023-Participant Study Found

The consolidated data show that telmisartan +/- HCTZ are well tolerated in patients of all ages and have placebo-like tolerabilities.

Blood pressure. Supplement • 2008-06-15 • Randomized Controlled Trial
N = 8,023 96/100 PMID 18705533 ↗
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