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Cancer, Oncology & Supportive Care • ICD-10-CM C25.9

Pancreatic Cancer

Also known as: Pancreas, Pancreatic, Adenoma, Adenomatous, Tumor

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM C25.9 • 8 Linked .gov / PubMed Citations • Governance: Dr. Devon Caldwell, DO, MPH (NPI #1568063758)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Pancreatic Cancer Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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3 of 3 Free Questions Remaining

What Is Pancreatic Cancer?

The pancreas is a gland behind your stomach and in front of your spine. It produces the juices that help break down food and the hormones that help control blood sugar levels. Pancreatic cancer usually begins in the cells that produce the juices. Some risk factors for developing pancreatic cancer include: Smoking Long-term diabetes Chronic pancreatitis Certain hereditary disorders Pancreatic cancer is hard to catch early. It doesn't cause symptoms right away. When you do get symptoms, they are often vague or you may not notice them. They include yellowing of the skin and eyes, pain in the abdomen and back, weight loss and fatigue.

Pathophysiology, Underlying Causes & Clinical Presentation

Pancreatic Cancer (C25.9) alters cancer & oncology homeostasis through tumor-suppressor loss enabling in Pancreatic Cancer (C25.9: clonal proliferation); Cross-referenced with NIH MeSH (Pancreatic Neoplasms), clinical remission targets Comprehensive Metabolic & in Pancreatic Cancer (C25.9: Organ Function Panel) within Preserved renal/hepatic clearance (C25.9).

Common Symptoms & Clinical Signs

  • • Long-term diabetes
  • • Chronic pancreatitis
  • • Presentation of Pancreatic Cancer (C25.9): unintended weight loss [Pancreatic Cancer C25.9]
  • • Secondary Pancreatic Cancer clinical sign: unexplained bleeding, chronic in Pancreatic Cancer (C25.9: hoarseness/cough, or progressive)

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Pancreatic Cancer Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code C25.9 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Cancer, Oncology & Supportive Care NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: Complete Blood Count in Pancreatic Cancer (C25.9: (ANC, Hemoglobin, Platelets)) Safe hematologic reserve (C25.9) Clinical Reference Target Range
Diagnostic / Lab Marker: Comprehensive Metabolic & in Pancreatic Cancer (C25.9: Organ Function Panel) Preserved renal/hepatic clearance (C25.9) Clinical Reference Target Range
Diagnostic / Lab Marker: Pathology / Molecular in Pancreatic Cancer (C25.9: Genomic Staging) Guideline-concordant surveillance (C25.9) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Pancreatic Cancer

Check Drug Interactions →
Medication Pharmacologic Class Patient Worth-It CMS NADAC / Unit Typical Lowest Cash
Pancrelipase Lipase, Pancrelipase Protease, Pancrelipase Amylase Zenpep • RxCUI 1594671 FDA Prescription Therapeutic Agent 86% $4.1778 $ 177.70 /mo
Pancrelipase Pertzye, Creon • RxCUI 1294122 FDA Prescription Therapeutic Agent 83% $2.6645 $ 116.41 /mo
Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Pancreatic Cancer)

Browse All PubMed Translations →
Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Postoperative Pain Treatment After Pancreatic: What a 1,468-Participant Study Found

The available evidence was insufficient to establish the superiority of any single pain-relieving strategy after major pancreatic surgery.

European journal of pain (London, England) • 2026-11-15 • Meta-Analysis
N = 1,468 99/100 PMID 42944586 ↗
Managing Advanced pancreatic cancer: Can Mistletoe extract Make a Real Difference? (What a 290-Person Study Found)

Since no benefit was observed, there is no clinical reason to recommend mistletoe extract in patients with advanced pancreatic cancer.

Palliative medicine • 2026-07-15 • Phase III Randomized Trial
N = 290 93/100 PMID 42059487 ↗
New Insights on Health-related quality of life scores of metastatic pancreatic cancer patients: What a 466-Participant Study Found

This is the first study to systematically derive EORTC QLQ-C30 reference values for mPC.

BMC cancer • 2022-05-20 • Phase III Randomized Trial
N = 466 93/100 PMID 35596182 ↗
Can This Approach Help? Inside the Latest Research on A Deep Prostate-specific Antigen Response to Darolutamide plus Androgen

Darolutamide resulted in deep and durable PSA responses, regardless of baseline PSA.

European urology oncology • 2025-10-15 • Phase III Randomized Trial
Multi-cohort 88/100 PMID 40846621 ↗
Can This Approach Help? Inside the Latest Research on Subcutaneous tirzepatide versus placebo or semaglutide on pancreatic islet

The glycaemic efficacy of GIP/GLP-1 receptor agonist tirzepatide in type 2 diabetes results from concurrent improvements in key components of diabetes pathophysiology, namely β-cell function, insulin sensitivity, and glucagon...

The lancet. Diabetes & endocrinology • 2022-06-15 • Randomized Controlled Trial
N = 117 88/100 PMID 35468322 ↗
Zero-PHI Patient Support & Cohort Discussions

Pancreatic Cancer Patient Community & “People Like Me” Threads

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