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Chronic Kidney Disease & Electrolytes • ICD-10-CM K65.9

Peritoneal Disorders

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM K65.9 • 8 Linked .gov / PubMed Citations • Governance: Dr. Julian Sterling, MD, FACS (NPI #1376841536)
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Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Peritoneal Disorders Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

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What Is Peritoneal Disorders?

Your peritoneum is the tissue that lines your abdominal wall and covers most of the organs in your abdomen. A liquid, peritoneal fluid, lubricates the surface of this tissue. Disorders of the peritoneum are not common. They include: Peritonitis - an inflammation of the peritoneum Cancer Complications from peritoneal dialysis Your doctor may use imaging tests or lab tests to analyze the peritoneal fluid to diagnose the problem. Treatment of peritoneal disorders depends on the cause.

Pathophysiology, Underlying Causes & Clinical Presentation

In Peritoneal Disorders (K65.9), physiological disruption stems from impaired nephron solute/acid-base in Peritoneal Disorders (K65.9: clearance), Cross-referenced with NIH MeSH (Peritoneal Diseases), informing Chronic Kidney Disease & Electrolytes protocols that track Serum Potassium, Bicarbonate in Peritoneal Disorders (K65.9: & Phosphorus) (K+ 3.8–4.8 mEq/L; HCO3 23–29 mEq/L (K65.9)).

Common Symptoms & Clinical Signs

  • • Peritonitis - an inflammation of the peritoneum
  • • Complications from peritoneal dialysis
  • • Presentation of Peritoneal Disorders (K65.9): fluid retention in in Peritoneal Disorders (K65.9: ankles, hands, or)
  • • Secondary Peritoneal Disorders clinical sign: fatigue, muscle cramps, in Peritoneal Disorders (K65.9: metallic taste, or)

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Peritoneal Disorders Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code K65.9 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Chronic Kidney Disease & Electrolytes NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: Urine Albumin-to-Creatinine Ratio in Peritoneal Disorders (K65.9: (uACR)) < 15 mg/g (< 30 mg/g normal) (K65.9) Clinical Reference Target Range
Diagnostic / Lab Marker: Serum Potassium, Bicarbonate in Peritoneal Disorders (K65.9: & Phosphorus) K+ 3.8–4.8 mEq/L; HCO3 23–29 mEq/L (K65.9) Clinical Reference Target Range
Diagnostic / Lab Marker: eGFR (Creatinine + in Peritoneal Disorders (K65.9: Cystatin C)) >= 90 mL/min/1.73m2 (K65.9) Clinical Reference Target Range
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FDA-Monographed Medications & Public Cash Price Reference for Peritoneal Disorders

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Treatment selection for Peritoneal Disorders depends on clinical severity, diagnostic lab results, and medical history. Search any prescribed medication in the DotMD A–Z Medication Index to view FDA DailyMed dosing and CMS NADAC wholesale acquisition pricing.

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Peer-Reviewed Human Clinical Trials & Meta-Analyses (Peritoneal Disorders)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Phase III Randomized Trial of Maintenance Taxanes Versus Surveillance in Women: What a 1,157-Participant Study Found

Maintenance therapy with P and PP did not improve OS among patients with newly diagnosed O/tubal/peritoneal cancer, but may modestly increase PFS.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2022-12-10 • Phase III Randomized Trial
N = 1,157 90/100 PMID 35759733 ↗
Can This Approach Help? Inside the Latest Research on Effect of intraperitoneal ropivacaine during and after cytoreductive surgery on

Intraperitoneal local anaesthetic did not shorten the time to RIOT among women undergoing surgery for advanced ovarian cancer in this trial.

British journal of anaesthesia • 2025-03-15 • Phase III Randomized Trial
N = 113 88/100 PMID 39572271 ↗
Can This Approach Help? Inside the Latest Research on Systemic Inflammatory Markers Correlate with Chronic Kidney Disease-Associated

These findings indicate that chronic kidney disease-associated severe itching intensity is linked to systemic inflammation, potentially through a neuroimmune crosstalk mechanism.

The Journal of investigative dermatology • 2026-01-15 • Phase III Randomized Trial
Multi-cohort 88/100 PMID 40409676 ↗
New Insights on Three-year outcomes of the randomized phase III SEIPLUS trial of extensive: What a 662-Participant Study Found

The pattern of disease recurrence is similar in the two groups.

Nature communications • 2021-11-15 • Phase III Randomized Trial
N = 662 87/100 PMID 34782599 ↗
Can This Approach Help? Inside the Latest Research on Any impact of pre-operative radiotherapy on kidney function in retroperitoneal

After prolonged follow-up of 80 months, the risk of kidney complications did not seem increased by a pre-operative radiation approach as shown in this ancillary study of the STRASS.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology • 2026-09-15 • Phase III Randomized Trial
N = 181 82/100 PMID 42364816 ↗
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