Premenstrual Syndrome
Also known as: PMS
Methodology & AI Transparency ⓘ
Premenstrual Syndrome Key Takeaways
Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level
- 1 What it does: What is premenstrual syndrome (PMS)? Premenstrual syndrome, or PMS, is a group of physical and emotional symptoms that start one to two weeks before your period .
- 2 Real-world patient consensus: Diagnostic registry E28.5: Premenstrual Syndrome is managed within OB/GYN & PCOS (aka PMS).
- 3 Typical cash cost range: Clinicians assessing Premenstrual Syndrome focus on or benign leiomyoma in Premenstrual Syndrome (E28.5: smooth-muscle proliferation) and targeted history.
- 4 Top reported side effects / signs: Key OB/GYN & PCOS biomarkers for Premenstrual Syndrome (E28.5): Fasting Insulin & in Premenstrual Syndrome (E28.5: HbA1c) & CBC & Serum in Premenstrual Syndrome (E28.5: Ferritin (heavy bleeding)) (Ferritin > 50 ng/mL (E28.5)).
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What Is Premenstrual Syndrome?
What is premenstrual syndrome (PMS)? Premenstrual syndrome, or PMS, is a group of physical and emotional symptoms that start one to two weeks before your period . Most women have at least some symptoms of PMS, and the symptoms go away after their periods start. The symptoms may range from mild to severe. What is premenstrual dysphoric disorder (PMDD)? Premenstrual dysphoric disorder (PMDD) is a severe type of PMS. With PMDD, the symptoms are severe enough to interfere with your life. PMDD much less common than PMS. What causes premenstrual syndrome (PMS)? Researchers don't know exactly what causes PMS. Changes in hormone levels during the menstrual cycle may play a role.
Pathophysiology, Underlying Causes & Clinical Presentation
Premenstrual Syndrome (E28.5) alters ob/gyn & pcos homeostasis through or benign leiomyoma in Premenstrual Syndrome (E28.5: smooth-muscle proliferation); Cross-referenced with NIH MeSH (Premenstrual Dysphoric Disorder, Premenstrual Syndrome), clinical remission targets CBC & Serum in Premenstrual Syndrome (E28.5: Ferritin (heavy bleeding)) within Ferritin > 50 ng/mL (E28.5).
Common Symptoms & Clinical Signs
- • Breast swelling and tenderness
- • Bloating and weight gain
- • Presentation of Premenstrual Syndrome (E28.5): severe pelvic cramping [Premenstrual Syndrome E28.5]
- • Secondary Premenstrual Syndrome clinical sign: hyperandrogenic acne along in Premenstrual Syndrome (E28.5: the jawline, hirsutism,)
Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗
Premenstrual Syndrome Diagnostic Classification & Lab Markers
| Metric | Verified Benchmark | Source |
|---|---|---|
| ICD-10-CM Diagnostic Code | E28.5 | WHO / CMS ICD-10-CM Clinical Classification |
| Clinical Specialty Hub | PCOS, Endometriosis & Gynecologic Health | NIH MedlinePlus Health Topics |
| Diagnostic / Lab Marker: Fasting Insulin & in Premenstrual Syndrome (E28.5: HbA1c) | Fasting insulin < 8 uIU/mL (E28.5) | Clinical Reference Target Range |
| Diagnostic / Lab Marker: CBC & Serum in Premenstrual Syndrome (E28.5: Ferritin (heavy bleeding)) | Ferritin > 50 ng/mL (E28.5) | Clinical Reference Target Range |
| Diagnostic / Lab Marker: LH, FSH & in Premenstrual Syndrome (E28.5: Prolactin) | Normal ovulatory endocrine axis (E28.5) | Clinical Reference Target Range |
FDA-Monographed Medications & Public Cash Price Reference for Premenstrual Syndrome
Treatment selection for Premenstrual Syndrome depends on clinical severity, diagnostic lab results, and medical history. Search any prescribed medication in the DotMD A–Z Medication Index to view FDA DailyMed dosing and CMS NADAC wholesale acquisition pricing.
Peer-Reviewed Human Clinical Trials & Meta-Analyses (Premenstrual Syndrome)
| Study & Plain-English Finding | Sample (N) | Rigor | Primary Source |
|---|---|---|---|
| Can This Approach Help? Inside the Latest Research on Variable dosing of sertraline for premenstrual exacerbation of The use of variable dosing in PMED increases the effectiveness of treatment. Journal of women's health (2002) • 2008-01-15 • Randomized Controlled Trial | Multi-cohort | 88/100 | PMID 18681820 ↗ |
| Can This Approach Help? Inside the Latest Research on Progesterone effects during sequential hormone replacement In women without prior PMS natural progesterone caused negative mood effects similar to those induced by synthetic progestogens. European journal of endocrinology • 2003-05-15 • Randomized Controlled Trial | N = 36 | 88/100 | PMID 12720542 ↗ |
| Can This Approach Help? Inside the Latest Research on E4/DRSP on self-reported physical and emotional premenstrual and menstrual E4/DRSP starters experienced significant improvements in the domains Pain, Water Retention and Negative Affect particularly benefiting those with more severe baseline symptoms. The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception • 2024-08-15 • Phase III Randomized Trial | Multi-cohort | 82/100 | PMID 38904165 ↗ |
| Can This Approach Help? Inside the Latest Research on Adverse mood effects during postmenopausal hormone treatment in relation to Women with a history of PMS and women with a high anxiety-related personality might respond with adverse mood effects to a combination of estrogen and sequential progestin and therefore a thorough evaluation should be made, at... Climacteric : the journal of the International Menopause Society • 2006-08-15 • Randomized Controlled Trial | N = 106 | 82/100 | PMID 16857659 ↗ |
Premenstrual Syndrome Patient Community & “People Like Me” Threads
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