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Chronic Kidney Disease & Electrolytes • ICD-10-CM R80.9

Proteinuria

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM R80.9 • 8 Linked .gov / PubMed Citations • Governance: Dr. Julian Sterling, MD, FACS (NPI #1376841536)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Proteinuria Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Proteinuria?

For patients presenting with Proteinuria (ICD-10-CM R80.9), Chronic Kidney Disease & Electrolytes protocols prioritize strict blood pressure/glycemic in Proteinuria (R80.9: control) paired with baseline and interval Serum Potassium, Bicarbonate in Proteinuria (R80.9: & Phosphorus) assessment.

Pathophysiology, Underlying Causes & Clinical Presentation

Pathophysiologically, Proteinuria (ICD-10 R80.9) is driven by glomerular capillary hyperfiltration in Proteinuria (R80.9: barotrauma); specialists in Chronic Kidney Disease & Electrolytes monitor eGFR (Creatinine + in Proteinuria (R80.9: Cystatin C)) to gauge tissue recovery.

Common Symptoms & Clinical Signs

  • • Presentation of Proteinuria (R80.9): asymptomatic decline in in Proteinuria (R80.9: eGFR or persistent)
  • • Secondary Proteinuria clinical sign: fluid retention in in Proteinuria (R80.9: ankles, hands, or)
  • • Symptom flares in Proteinuria correlating with Serum Potassium, Bicarbonate in Proteinuria (R80.9: & Phosphorus) deviation outside K+ 3.8–4.8 mEq/L; HCO3 23–29 mEq/L (R80.9)
  • • Functional kidney & renal impact requiring strict blood pressure/glycemic in Proteinuria (R80.9: control) evaluation (R80.9)

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Proteinuria Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code R80.9 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Chronic Kidney Disease & Electrolytes NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: Serum Potassium, Bicarbonate in Proteinuria (R80.9: & Phosphorus) K+ 3.8–4.8 mEq/L; HCO3 23–29 mEq/L (R80.9) Clinical Reference Target Range
Diagnostic / Lab Marker: eGFR (Creatinine + in Proteinuria (R80.9: Cystatin C)) >= 90 mL/min/1.73m2 (R80.9) Clinical Reference Target Range
Diagnostic / Lab Marker: Urine Albumin-to-Creatinine Ratio in Proteinuria (R80.9: (uACR)) < 15 mg/g (< 30 mg/g normal) (R80.9) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Proteinuria

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Medication Pharmacologic Class Patient Worth-It CMS NADAC / Unit Typical Lowest Cash
Sibeprenlimab Voyxact • RxCUI 2728400 FDA Prescription Therapeutic Agent 74% $1.0800 $ 52.24 /mo
Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Proteinuria)

Browse All PubMed Translations →
Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Rosuvastatin and atorvastatin on kidney function:: What a 24,278-Participant Study Found

Both RSV and ATV improve GFR, and ATV seems to be more effective in reducing proteinuria.

Circulation journal : official journal of the Japanese Circulation Society • 2012-01-15 • Meta-Analysis
N = 24,278 99/100 PMID 22382383 ↗
New Insights on Atorvastatin and rosuvastatin on kidney: What a 29,147-Participant Study Found

A and R show similar reno-protective effects in patients at high heart and blood vessel risk, with comparable rates of new onset proteinuria when commonly used doses are considered.

International journal of cardiology • 2013-09-10 • Meta-Analysis
N = 29,147 99/100 PMID 22633671 ↗
New Insights on A clinical trial in type 2 diabetic: What a 1,715-Participant Study Found

This large-scale international trial should help define the clinical course and standards of care for hypertensive adults with type 2.

American journal of kidney diseases : the official journal of the National Kidney Foundation • 2001-10-15 • Randomized Controlled Trial
N = 1,715 96/100 PMID 11576953 ↗
New Insights on Kidney effects of atorvastatin and rosuvastatin in patients with diabetes who: What a 353-Participant Study Found

Despite high-dose rosuvastatin lowering plasma lipid concentrations to a greater extent than did high-dose atorvastatin, atorvastatin seems to have more renoprotective effects for the studied chronic kidney disease population.

The lancet. Diabetes & endocrinology • 2015-03-15 • Randomized Controlled Trial
N = 353 93/100 PMID 25660356 ↗
New Insights on Telmisartan is more effective than losartan in reducing proteinuria in patients: What a 860-Participant Study Found

Mean systolic blood pressure reductions were not significantly different between groups at trial end.

Kidney international • 2008-08-15 • Randomized Controlled Trial
N = 860 93/100 PMID 18496508 ↗
Zero-PHI Patient Support & Cohort Discussions

Proteinuria Patient Community & “People Like Me” Threads

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