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Depression, Bipolar & Mood Disorders • ICD-10-CM F54

Psychosomatic disease

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM F54 • 7 Linked .gov / PubMed Citations • Governance: Dr. Hannah Lindqvist, MD, PhD (NPI #1457952647)
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Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Psychosomatic disease Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

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What Is Psychosomatic disease?

Cataloged under federal diagnostic code F54 in Depression & Mood, Psychosomatic disease requires validated longitudinal mood in Psychosomatic disease (F54: rating scales (PHQ-9) so specialists can calibrate treatment intensity against PHQ-9 Symptom Severity in Psychosomatic disease (F54: Score) benchmarks.

Pathophysiology, Underlying Causes & Clinical Presentation

In Psychosomatic disease (F54), physiological disruption stems from circadian phase instability [Psychosomatic disease F54], informing Depression, Bipolar & Mood Disorders protocols that track TSH & Free in Psychosomatic disease (F54: T4 Rule-Out) (TSH 0.8 – 2.5 mIU/L (F54)).

Common Symptoms & Clinical Signs

  • • Presentation of Psychosomatic disease (F54): slowed concentration, indecisiveness, in Psychosomatic disease (F54: and physical heaviness)
  • • Secondary Psychosomatic disease clinical sign: loss of interest in Psychosomatic disease (F54: or pleasure in)
  • • Symptom flares in Psychosomatic disease correlating with PHQ-9 Symptom Severity in Psychosomatic disease (F54: Score) deviation outside < 4 (clinical remission) (F54)
  • • Functional depression & mood impact requiring validated longitudinal mood in Psychosomatic disease (F54: rating scales (PHQ-9) evaluation (F54)

Psychosomatic disease Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code F54 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Depression, Bipolar & Mood Disorders NLM Clinical Tables
Diagnostic / Lab Marker: PHQ-9 Symptom Severity in Psychosomatic disease (F54: Score) < 4 (clinical remission) (F54) Clinical Reference Target Range
Diagnostic / Lab Marker: TSH & Free in Psychosomatic disease (F54: T4 Rule-Out) TSH 0.8 – 2.5 mIU/L (F54) Clinical Reference Target Range
Diagnostic / Lab Marker: Serum Vitamin D in Psychosomatic disease (F54: & RBC Folate) 25(OH)D 40 – 65 ng/mL (F54) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Psychosomatic disease

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Medication Pharmacologic Class Patient Worth-It CMS NADAC / Unit Typical Lowest Cash
Carbamazepine ER Carbatrol • RxCUI 199378 Mood Stabilizer 84% $0.1989 $ 7.25 /mo
Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Psychosomatic disease)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Efficacy, tolerability, and acceptability of bupropion for: What a 1,117-Participant Study Found

According to the limited data obtained from three RCTs, bupropion XL is as effective and tolerable as venlafaxine XR for adult patients with MDD.

Drug design, development and therapy • 2013-01-15 • Meta-Analysis
N = 1,117 94/100 PMID 24101861 ↗
Can This Approach Help? Inside the Latest Research on Effect of AXS-05 (Dextromethorphan-Bupropion) in depression: A Randomized

In patients with major depression, dextromethorphan-bupropion (AXS-05) significantly improved depressive symptoms compared with bupropion and was generally well tolerated.

The American journal of psychiatry • 2022-07-15 • Randomized Controlled Trial
N = 43 88/100 PMID 35582785 ↗
Can This Approach Help? Inside the Latest Research on Sexual Function With Adjunctive Lumateperone in Patients With

Conclusions: Adjunctive lumateperone 42 mg did not worsen sexual functioning and was not associated with treatment-related sexual dysfunction in patients with MDD with inadequate response to ADT.

The Journal of clinical psychiatry • 2026-09-02 • Phase III Randomized Trial
Multi-cohort 88/100 PMID 42690086 ↗
Can This Approach Help? Inside the Latest Research on Antipsychotic Medication on Brain Structure in Patients With depression and

Eighty-eight participants (age range, 18-85 years) completed a baseline scan; 75 completed a follow-up scan, of which 72 (32 men and 40 women) were useable for final analyses.

JAMA psychiatry • 2020-07-01 • Randomized Controlled Trial
Multi-cohort 88/100 PMID 32101271 ↗
Can This Approach Help? Inside the Latest Research on Benefits and safety of Flexibly Dosed Esketamine Nasal Spray Combined With a

Current treatment options for treatment-resistant depression have considerable limitations in terms of efficacy and patient acceptability.

The American journal of psychiatry • 2019-06-01 • Phase III Randomized Trial
Multi-cohort 88/100 PMID 31109201 ↗
Zero-PHI Patient Support & Cohort Discussions

Psychosomatic disease Patient Community & “People Like Me” Threads

“People Like Me” Cohort Filter (Zero-PHI)

Filter Psychosomatic disease community threads and patient logs by age, biological sex, dosage, and treatment duration.

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