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Depression, Bipolar & Mood Disorders • ICD-10-CM F21

Schizotypal personality

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM F21 • 8 Linked .gov / PubMed Citations • Governance: Dr. Hannah Lindqvist, MD, PhD (NPI #1457952647)
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Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Schizotypal personality Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

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What Is Schizotypal personality?

Within Depression, Bipolar & Mood Disorders practice, Schizotypal personality (ICD-10 F21) is stratified through sleep-wake rhythm assessment [Schizotypal personality F21], pairing targeted symptom control with longitudinal TSH & Free in Schizotypal personality (F21: T4 Rule-Out) surveillance.

Pathophysiology, Underlying Causes & Clinical Presentation

At the cellular and tissue level in depression & mood, Schizotypal personality (F21) involves monoaminergic (serotonin [Schizotypal personality F21]. progression correlates with shifts in PHQ-9 Symptom Severity in Schizotypal personality (F21: Score) (< 4 (clinical remission) (F21)).

Common Symptoms & Clinical Signs

  • • Presentation of Schizotypal personality (F21): loss of interest in Schizotypal personality (F21: or pleasure in)
  • • Secondary Schizotypal personality clinical sign: persistent low mood, in Schizotypal personality (F21: emotional flatness, or)
  • • Symptom flares in Schizotypal personality correlating with PHQ-9 Symptom Severity in Schizotypal personality (F21: Score) deviation outside < 4 (clinical remission) (F21)
  • • Functional depression & mood impact requiring sleep-wake rhythm assessment [Schizotypal personality F21] evaluation (F21)

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Schizotypal personality Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code F21 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Depression, Bipolar & Mood Disorders NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: PHQ-9 Symptom Severity in Schizotypal personality (F21: Score) < 4 (clinical remission) (F21) Clinical Reference Target Range
Diagnostic / Lab Marker: TSH & Free in Schizotypal personality (F21: T4 Rule-Out) TSH 0.8 – 2.5 mIU/L (F21) Clinical Reference Target Range
Diagnostic / Lab Marker: Serum Vitamin D in Schizotypal personality (F21: & RBC Folate) 25(OH)D 40 – 65 ng/mL (F21) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Schizotypal personality

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Medication Pharmacologic Class Patient Worth-It CMS NADAC / Unit Typical Lowest Cash
Carbamazepine ER Carbatrol • RxCUI 199378 Mood Stabilizer 84% $0.1989 $ 7.25 /mo
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Peer-Reviewed Human Clinical Trials & Meta-Analyses (Schizotypal personality)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Antidepressant side effects and their impact on treatment outcome in people with: What a 1,008-Participant Study Found

ISPOT-D: Registry name: ClinicalTrials.gov.

Translational psychiatry • 2021-08-04 • Randomized Controlled Trial
N = 1,008 90/100 PMID 34349116 ↗
Can This Approach Help? Inside the Latest Research on Effect of AXS-05 (Dextromethorphan-Bupropion) in depression: A Randomized

In patients with major depression, dextromethorphan-bupropion (AXS-05) significantly improved depressive symptoms compared with bupropion and was generally well tolerated.

The American journal of psychiatry • 2022-07-15 • Randomized Controlled Trial
N = 43 88/100 PMID 35582785 ↗
Can This Approach Help? Inside the Latest Research on Benefits and safety of Flexibly Dosed Esketamine Nasal Spray Combined With a

Current treatment options for treatment-resistant depression have considerable limitations in terms of efficacy and patient acceptability.

The American journal of psychiatry • 2019-06-01 • Phase III Randomized Trial
Multi-cohort 88/100 PMID 31109201 ↗
New Insights on A compared against a dummy pill (placebo), randomized withdrawal study of: What a 235-Participant Study Found

Sertraline was well-tolerated, with similar side effects as found in previous studies.

International clinical psychopharmacology • 2006-01-15 • Randomized Controlled Trial
N = 235 88/100 PMID 16317311 ↗
Can This Approach Help? Inside the Latest Research on Tetrahydrocurcumin for depression with Therapeutic Potential and Mechanistic

THC demonstrates antidepressant potential through anti-inflammatory and neuroprotective mechanisms, supporting its use as a safe augmentation strategy in MDD treatment.

Molecular neurobiology • 2025-12-23 • Randomized Controlled Trial
N = 19 82/100 PMID 41432971 ↗
Zero-PHI Patient Support & Cohort Discussions

Schizotypal personality Patient Community & “People Like Me” Threads

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