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PCOS, Endometriosis & Gynecologic Health • ICD-10-CM N81.4

Uterine prolapse

Also known as: Uterus, Womb, Myometrium, Uterine

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM N81.4 • 8 Linked .gov / PubMed Citations • Governance: Dr. Elena Vance, MD, FACE (NPI #1043218901)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Uterine prolapse Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Uterine prolapse?

Clinical triage of Uterine prolapse (also termed Uterus or Womb) (N81.4) in OB/GYN & PCOS relies on metabolic/thyroid/prolactin hormone panels [Uterine prolapse N81.4], guiding step-wise therapeutic adjustments toward Free & Total in Uterine prolapse (N81.4: Testosterone + SHBG) (Sex-specific physiological range (N81.4)).

Pathophysiology, Underlying Causes & Clinical Presentation

In Uterine prolapse (N81.4), physiological disruption stems from or benign leiomyoma in Uterine prolapse (N81.4: smooth-muscle proliferation), informing PCOS, Endometriosis & Gynecologic Health protocols that track Free & Total in Uterine prolapse (N81.4: Testosterone + SHBG) (Sex-specific physiological range (N81.4)).

Common Symptoms & Clinical Signs

  • • Presentation of Uterine prolapse (N81.4): pelvic pressure, bloating, in Uterine prolapse (N81.4: or pain radiating)
  • • Secondary Uterine prolapse clinical sign: irregular, infrequent, or in Uterine prolapse (N81.4: absent ovulatory menstrual)
  • • Symptom flares in Uterine prolapse correlating with LH, FSH & in Uterine prolapse (N81.4: Prolactin) deviation outside Normal ovulatory endocrine axis (N81.4)
  • • Functional ob/gyn & pcos impact requiring metabolic/thyroid/prolactin hormone panels [Uterine prolapse N81.4] evaluation (N81.4)

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Uterine prolapse Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code N81.4 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub PCOS, Endometriosis & Gynecologic Health NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: LH, FSH & in Uterine prolapse (N81.4: Prolactin) Normal ovulatory endocrine axis (N81.4) Clinical Reference Target Range
Diagnostic / Lab Marker: Free & Total in Uterine prolapse (N81.4: Testosterone + SHBG) Sex-specific physiological range (N81.4) Clinical Reference Target Range
Diagnostic / Lab Marker: Fasting Insulin & in Uterine prolapse (N81.4: HbA1c) Fasting insulin < 8 uIU/mL (N81.4) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Uterine prolapse

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Treatment selection for Uterine prolapse depends on clinical severity, diagnostic lab results, and medical history. Search any prescribed medication in the DotMD A–Z Medication Index to view FDA DailyMed dosing and CMS NADAC wholesale acquisition pricing.

Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Uterine prolapse)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Pain Reduction in Linzagolix-Treated Patients With Uterine Fibroids: A Secondary: What a 1,012-Participant Study Found

This analysis showed that reductions in pain were significantly mediated by reductions in HMB (all doses) and FV (200 mg alone) in linzagolix-treated women with UFs.

BJOG : an international journal of obstetrics and gynaecology • 2025-08-15 • Phase III Randomized Trial
N = 1,012 96/100 PMID 40326221 ↗
New Insights on Relugolix combination therapy in European women with symptomatic uterine: What a 388-Participant Study Found

In European women with UF and HMB, once-daily relugolix-CT vs.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology • 2023-08-17 • Phase III Randomized Trial
N = 388 93/100 PMID 37634528 ↗
What the Latest Evidence Really Says About Effects of sildenafil citrate on intrauterine growth

Sildenafil citrate increases birth weight and prolonged pregnancies but did not affect stillbirth rate, neonatal death, and NICU admission.

BMC pregnancy and childbirth • 2023-06-02 • Meta-Analysis
Multi-cohort 92/100 PMID 37268873 ↗
Can This Approach Help? Inside the Latest Research on Once Daily Oral Relugolix Combination Therapy Versus Placebo in Patients With

The author describes the results of a study to examine the effect of three treatment regimens on pain associated with endometriosis.

Journal of obstetric, gynecologic, and neonatal nursing : JOGNN • 2024-11-15 • Phase III Randomized Trial
Multi-cohort 88/100 PMID 39395815 ↗
Can This Approach Help? Inside the Latest Research on Effects of magnesium supplementation on abnormal uterine bleeding, hair loss,

Magnesium supplementation in women with PCOS had a significant positive effect on improving total quality of life.

Reproductive biology and endocrinology : RB&E • 2022-08-02 • Randomized Controlled Trial
N = 64 88/100 PMID 35918728 ↗
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Uterine prolapse Patient Community & “People Like Me” Threads

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